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Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.
Open accessAbstract
Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
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“In humans, artificially boosting baroreceptor activation reduces pain sensation 53 .”
From Interoceptive rhythms in the brain (2023) · cites this paper as [53]
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Metadata
- Authors
- Dworkin, B. R., Elbert, T., Rau, H., Birbaumer, N., Pauli, P., Droste, C., & Brunia, C. H.
- Affiliations
- Pennsylvania State University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6329-6333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44195
- OpenAlex
- W2119445707
- Cited by
- 251
- References
- 27
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 8
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research portal (Tilburg University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by-nc-nd)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL40837, R01HL040837)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- baroreceptor activation, pain perception, Achilles tendon reflex, central nervous system inhibition, blood pressure regulation, cardiovascular reactivity, essential hypertension
- MeSH terms
- Achilles Tendon, Adult, Analysis of Variance, Blood Pressure, Carotid Arteries, Central Nervous System, Electric Stimulation, Humans, Hypertension, Middle Aged, Muscle, Smooth, Vascular, Pain, Pressoreceptors, Reflex, Sensory Thresholds, Myocardial Ischemia
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