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P-selectin induces the expression of tissue factor on monocytes.
Open accessAbstract
P-selectin on activated platelets and stimulated endothelial cells mediates cell adhesion with monocytes and neutrophils. Since activated platelets induce tissue factor on mononuclear leukocytes, we examined the effect of P-selectin on the expression of tissue factor activity in monocytes. Purified P-selectin stimulated tissue factor expression on mononuclear leukocytes in a dose-dependent manner. Chinese hamster ovary (CHO) cells expressing P-selectin stimulated tissue factor procoagulant activity in purified monocytes, whereas untransfected CHO cells and CHO cells expressing E-selectin did not. Anti-P-selectin antibodies inhibited the effects of purified P-selectin and CHO cells expressing P-selectin on monocytes. Incubation of CHO cells expressing P-selectin with monocytes leads to the development of tissue factor mRNA in monocytes and to the expression of tissue factor antigen on the monocyte surface. These results indicate that P-selectin upregulates the expression of tissue factor on monocytes as well as mediates the binding of platelets and endothelial cells with monocytes and neutrophils. The binding of P-selectin to monocytes in the area of vascular injury may be a component of a mechanism that initiates thrombosis.
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Citations
Cited by
Mechanisms That Regulate the Function of the Selectins and Their Ligands
VESTWEBER, D., & BLANKS, J. E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.181 · Cited by 932
Borsig, L., Wong, R., Feramisco, J., Nadeau, D. R., Varki, N. M., & Varki, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061615598 · Cited by 714
Platelets in inflammation and thrombosis
Wagner, D. D., & Burger, P. C. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095974.95122.ec · Cited by 570
Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions
McEver, R. P., Moore, K. L., & Cummings, R. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11025 · Cited by 512
Wahrenbrock, M., Borsig, L., Le, D., Varki, N., & Varki, A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318882 · Cited by 317
Metadata
- Authors
- Celi, A., Pellegrini, G., Lorenzet, R., De Blasi, A., Ready, N., Furie, B. C., & Furie, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-09-13
- Volume
- 91
- Issue
- 19
- Pages
- 8767-8771
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080455788
- Cited by
- 590
- References
- 0
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Celi, A., Pellegrini, G., Lorenzet, R., De Blasi, A., Ready, N., Furie, B. C., & Furie, B. (1994). P-selectin induces the expression of tissue factor on monocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.19.8767
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