Platelets in inflammation and thrombosis

Wagner, Denisa D.; Burger, Peter C.

doi:10.1161/01.atv.0000095974.95122.ec

Cited by 570Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis MechanismsCell Adhesion Molecules Research

Platelets in inflammation and thrombosis

Wagner, Denisa D., Burger, Peter C.·2003·Arteriosclerosis Thrombosis and Vascular Biology

DOI 10.1161/01.atv.0000095974.95122.ec

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Abstract

For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.

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Activated platelets can release PDGF, VEGF, and IL-8.
“Consequent to vascular damage, activated platelets can also release an array of cellular growth factors and angiogenic factors such as PDGF and VEGF, as well as inflammatory mediators such as IL-8 [79,80,81].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [81]

Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009 · see citing works
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,789 · see citing works
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738 · see citing works
Thrombin signalling and protease-activated receptors
Coughlin, S. R. (2000) · Nature · doi:10.1038/35025229 · Cited by 2,495 · see citing works
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Henn, V., Slupsky, J. R., Gräfe, M., Anagnostopoulos, I., Förster, R., MÜLLER‐BERGHAUS, G., & Kroczek, R. A. (1998) · Nature · doi:10.1038/35393 · Cited by 2,082 · see citing works
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Levy, G. G., Nichols, W. C., Lian, E., Foroud, T., McClintick, J. N., McGee, B. M., Yang, A. Y., Siemieniak, D. R., Stark, K. R., Gruppo, R. A., et al. (2001) · Nature · doi:10.1038/35097008 · Cited by 1,744 · see citing works
CD40-CD40 ligand
van Kooten, C., & Banchereau, J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.2 · Cited by 1,413 · see citing works
Initiation of Platelet Adhesion by Arrest onto Fibrinogen or Translocation on von Willebrand Factor
Savage, B., Saldı́var, E., & Ruggeri, Z. M. (1996) · Cell · doi:10.1016/s0092-8674(00)80983-6 · Cited by 1,218 · see citing works
Platelet-collagen interaction: is GPVI the central receptor?
Nieswandt, B., & Watson, S. P. (2003) · Blood · doi:10.1182/blood-2002-12-3882 · Cited by 1,152 · see citing works
NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA
Weibel, E. R., & Palade, G. E. (1964) · The Journal of Cell Biology · doi:10.1083/jcb.23.1.101 · Cited by 1,080 · see citing works
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
Mayadas, T. N., Johnson, R. C., Rayburn, H., Hynes, R. O., & Wagner, D. D. (1993) · Cell · doi:10.1016/0092-8674(93)80055-j · Cited by 1,040 · see citing works
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Huo, Y., Schober, A., Forlow, S. B., Smith, D. F., Hyman, M. C., Jung, S., Littman, D. R., Weber, C., & Ley, K. F. (2002) · Nature Medicine · doi:10.1038/nm810 · Cited by 1,008 · see citing works
Blood-borne tissue factor: Another view of thrombosis
Giesen, P. L. A., Rauch, U., Bohrmann, B., Kling, D., Roqué, M., Fallon, J. T., Badimón, J. J., Himber, J., Riederer, M. A., & Nemerson, Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2311 · Cited by 990 · see citing works
GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.
McEver, R. P., Beckstead, J. H., Moore, K. L., Marshall-Carlson, L., & Bainton, D. F. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114175 · Cited by 973 · see citing works
Reduction of atherosclerosis in mice by inhibition of CD40 signalling
Mach, F., Schönbeck, U., Sukhova, G. K., Atkinson, E., & Libby, P. (1998) · Nature · doi:10.1038/28204 · Cited by 910 · see citing works
A Critical Role of Platelet Adhesion in the Initiation of Atherosclerotic Lesion Formation
Maßberg, S., Brand, K., Grüner, S., Page, S., Müller, E., Müller, I. I., Bergmeier, W., Richter, T., Lorenz, M. C., Konrad, I., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012044 · Cited by 881 · see citing works
PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes
Larsen, E. C., Celi, A., Gilbert, G. E., Furie, B. C., Erban, J. K., Bonfanti, R., Wagner, D. D., & Furie, B. (1989) · Cell · doi:10.1016/0092-8674(89)90292-4 · Cited by 864 · see citing works
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
Dong, J.-F., Moake, J. L., Nolasco, L. H., Bernardo, A., Arceneaux, W., Shrimpton, C. N., Schade, A. J., McIntire, L. V., Fujikawa, K., & López, J. A. (2002) · Blood · doi:10.1182/blood-2002-05-1401 · Cited by 858 · see citing works
Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow
Savage, B., Almus-Jacobs, F., & Ruggeri, Z. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81607-4 · Cited by 816 · see citing works
Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets
Palabrica, T. M., Lobb, R. R., Furie, B. C., Aronovitz, M. J., Benjamin, C. D., Hsu, Y., Sajer, S. A., & Furie, B. (1992) · Nature · doi:10.1038/359848a0 · Cited by 811 · see citing works
Accumulation of Tissue Factor into Developing Thrombi In Vivo Is Dependent upon Microparticle P-Selectin Glycoprotein Ligand 1 and Platelet P-Selectin
Falati, S., Liu, Q., Gross, P. L., Merrill‐Skoloff, G., Chou, J., Vandendries, E. R., Celi, A., Croce, K., Furie, B. C., & Furie, B. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021868 · Cited by 752 · see citing works
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism
André, P., Prasad, K. S. S., Denis, C. V., He, M.-S., Papalia, J. M., Hynes, R. O., Phillips, D. R., & Wagner, D. D. (2002) · Nature Medicine · doi:10.1038/nm0302-247 · Cited by 725 · see citing works
Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
Wagner, D. D. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.355 · Cited by 703 · see citing works
Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis
Lindemann, S., Tolley, N. D., Dixon, D. A., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A., & Weyrich, A. S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105058 · Cited by 700 · see citing works
Human blood platelet adhesion to artery subendothelium is mediated by factor VIII–Von Willebrand factor bound to the subendothelium
Sakaríassen, K. S., Bolhuis, P. A., & Sixma, J. J. (1979) · Nature · doi:10.1038/279636a0 · Cited by 652 · see citing works
Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis
Loscalzo, J. (2001) · Circulation Research · doi:10.1161/hh0801.089861 · Cited by 612 · see citing works
Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A
Bi, L., Lawler, A. M., Antonarakis, S. E., High, K. A., Gearhart, J. D., & Kazazian, H. H. (1995) · Nature Genetics · doi:10.1038/ng0595-119 · Cited by 593 · see citing works
P-selectin induces the expression of tissue factor on monocytes.
Celi, A., Pellegrini, G., Lorenzet, R., Blasi, A. D., Ready, N., Furie, B., & Furie, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8767 · Cited by 590 · see citing works
RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium
von Hundelshausen, P., Weber, K. S. C., Huo, Y., Proudfoot, A. E. I., Nelson, P. J., Ley, K. F., & Weber, C. (2001) · Circulation · doi:10.1161/01.cir.103.13.1772 · Cited by 583 · see citing works
Platelet-Derived CD40L
André, P., Nannizzi‐Alaimo, L., Prasad, S. K., & Phillips, D. R. (2002) · Circulation · doi:10.1161/01.cir.0000028962.04520.01 · Cited by 567 · see citing works
Soluble P-Selectin and the Risk of Future Cardiovascular Events
Ridker, P. M., Buring, J. E., & Rifai, N. (2001) · Circulation · doi:10.1161/01.cir.103.4.491 · Cited by 564 · see citing works
Bernard-Soulier Syndrome
López, J. A., Andrews, R. K., Afshar‐Kharghan, V., & Berndt, M. C. (1998) · Blood · doi:10.1182/blood.v91.12.4397 · Cited by 560 · see citing works
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
Bonfanti, R., Furie, B., Furie, B., & Wagner, D. D. (1989) · Blood · doi:10.1182/blood.v73.5.1109.1109 · Cited by 546 · see citing works
Fibronectins
Hynes, R. O. (1990) · Springer series in molecular biology · doi:10.1007/978-1-4612-3264-3 · Cited by 540 · see citing works
Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18
Diacovo, T., Roth, S. J., Buccola, J., Bainton, D., & Springer, T. (1996) · Blood · doi:10.1182/blood.v88.1.146.bloodjournal881146 · Cited by 535 · see citing works
A mouse model of severe von Willebrand disease: Defects in hemostasis and thrombosis
Denis, C. V., Methia, N., Frenette, P. S., Rayburn, H., Ullman-Culleré, M., Hynes, R. O., & Wagner, D. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9524 · Cited by 515 · see citing works
Susceptibility to Infection and Altered Hematopoiesis in Mice Deficient in Both P- and E-Selectins
Frenette, P. S., Mayadas, T. N., Rayburn, H., Hynes, R. O., & Wagner, D. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81032-6 · Cited by 508 · see citing works
P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice
Collins, R. G., Velji, R., Guevara, J., Hicks, J. M., Chan, L., & Beaudet, A. L. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.189 · Cited by 493 · see citing works
Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
Ni, H., Denis, C. V., Subbarao, S., Degen, J. L., Sato, T. N., Hynes, R. O., & Wagner, D. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9896 · Cited by 493 · see citing works
Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)
Du, X., Plow, E. F., Frelinger, A. L., O’Toole, T. E., Loftus, J. C., & Ginsberg, M. H. (1991) · Cell · doi:10.1016/0092-8674(91)90458-b · Cited by 485 · see citing works
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin.
Frenette, P. S., Johnson, R. C., Hynes, R. O., & Wagner, D. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7450 · Cited by 473 · see citing works
The combined role of P- and E-selectins in atherosclerosis.
Dong, Z. M., Chapman, S. M., Brown, A. A., Frenette, P. S., Hynes, R. O., & Wagner, D. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3001 · Cited by 460 · see citing works
Requirement for CD154 in the progression of atherosclerosis
Lutgens, E., Gorelik, L., Daemen, M. J. A. P., de Muinck, E. D., Grewal, I. S., Koteliansky, V., & Flavell, R. A. (1999) · Nature Medicine · doi:10.1038/15271 · Cited by 439 · see citing works
P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is Expressed on Platelets and Can Mediate Platelet–Endothelial Interactions in Vivo
Frenette, P. S., Denis, C. V., Weiss, L. A., Jurk, K., Subbarao, S., Kehrel, B. E., Hartwig, J. H., Vestweber, D., & Wagner, D. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1413 · Cited by 432 · see citing works
Platelet P-selectin facilitates atherosclerotic lesion development
Burger, P. C., & Wagner, D. D. (2003) · Blood · doi:10.1182/blood-2002-07-2209 · Cited by 409 · see citing works
Platelet-Endothelial Cell Interactions During Ischemia/Reperfusion: The Role of P-Selectin
Maßberg, S., Enders, G. A., Leiderer, R., Eisenmenger, S., Vestweber, D., Krombach, F., & Meßmer, K. (1998) · Blood · doi:10.1182/blood.v92.2.507.414k29_507_515 · Cited by 394 · see citing works
Decreased adhesion of platelets to subendothelium in von Willebrand's disease.
Tschopp, T. B., Weiss, H. J., & Baumgartner, H. R. (1974) · PubMed · Cited by 384 · see citing works
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
Weber, C., & Springer, T. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119742 · Cited by 382 · see citing works
Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.
Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, J. M., Lorenzo, I., Doyle, N. A., Doerschuk, C. M., Ley, K. F., & Beaudet, A. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.2329 · Cited by 372 · see citing works
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
Sakai, T., Johnson, K. J., Murozono, M., Sakai, K., Magnuson, M. A., Wieloch, T. W., Cronberg, T., Isshiki, A., Erickson, H., & Fässler, R. (2001) · Nature Medicine · doi:10.1038/85471 · Cited by 359 · see citing works
The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
Romo, G. M., Dong, J.-F., Schade, A. J., Gardiner, E. E., Kansas, G. S., Li, C. Q., McIntire, L. V., Berndt, M. C., & López, J. A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.803 · Cited by 355 · see citing works
Pro-coagulant state resulting from high levels of soluble P-selectin in blood
André, P., Hartwell, D. W., Hrachovinová, I., Saffaripour, S., & Wagner, D. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250475997 · Cited by 318 · see citing works
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
André, P., Denis, C. V., Ware, J. L., Saffaripour, S., Hynes, R. O., Ruggeri, Z. M., & Wagner, D. D. (2000) · Blood · doi:10.1182/blood.v96.10.3322 · Cited by 308 · see citing works
High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells
Nomura, S., Tandon, N. N., Nakamura, T., Cone, J. L., Fukuhara, S., & Kambayashi, J. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00433-6 · Cited by 304 · see citing works
Activated Platelets Induce Monocyte Chemotactic Protein-1 Secretion and Surface Expression of Intercellular Adhesion Molecule-1 on Endothelial Cells
Gawaz, M., Neumann, F., Dickfeld, T. L., Koch, W., Laugwitz, K., Adelsberger, H., Langenbrink, K., Page, S., Neumeier, D., Schömig, A., et al. (1998) · Circulation · doi:10.1161/01.cir.98.12.1164 · Cited by 298 · see citing works
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
Hrachovinová, I., Cambien, B., Hafezi‐Moghadam, A., Kappelmayer, J., Camphausen, R. T., Widom, A., Xia, L., Kazazian, H. H., Schaub, R. G., McEver, R. P., et al. (2003) · Nature Medicine · doi:10.1038/nm899 · Cited by 297 · see citing works
Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.
Goto, S., Ikeda, Y., Saldı́var, E., & Ruggeri, Z. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci973 · Cited by 285 · see citing works
Induction of specific storage organelles by von Willebrand factor propolypeptide
Wagner, D. D., Saffaripour, S., Bonfanti, R., Sadler, J. E., Cramer, E. M., Chapman, B. S., & Mayadas, T. N. (1991) · Cell · doi:10.1016/0092-8674(91)90648-i · Cited by 274 · see citing works
Direct Demonstration of P-Selectin– and VCAM-1–Dependent Mononuclear Cell Rolling in Early Atherosclerotic Lesions of Apolipoprotein E–Deficient Mice
Ramos, C. L., Huo, Y., Jung, U., Ghosh, S., Manka, D. R., Sarembock, I. J., & Ley, K. F. (1999) · Circulation Research · doi:10.1161/01.res.84.11.1237 · Cited by 272 · see citing works
The Weibel-Palade Body: the Storage Granule for von Willebrand Factor and P-selectin
Wagner, D. D. (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646169 · Cited by 265 · see citing works
Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice
Dong, Z. M., Brown, A. A., & Wagner, D. D. (2000) · Circulation · doi:10.1161/01.cir.101.19.2290 · Cited by 263 · see citing works
Platelets induce alterations of chemotactic and adhesive properties of endothelial cells mediated through an interleukin-1-dependent mechanism. Implications for atherogenesis
Gawaz, M., Brand, K., Dickfeld, T. L., Pogátsa-Murray, G., Page, S., Bogner, C., Koch, W., Schömig, A., & Neumann, F. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00241-5 · Cited by 254 · see citing works
Plasma P-selectin is increased in thrombotic consumptive platelet disorders
Chong, B., Murray, B., Berndt, M. C., Dunlop, L., Brighton, T., & Chesterman, C. (1994) · Blood · doi:10.1182/blood.v83.6.1535.1535 · Cited by 250 · see citing works
Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm
Miyagawa, K., Rösch, J., Stanczyk, F. Z., & Hermsmeyer, K. (1997) · Nature Medicine · doi:10.1038/nm0397-324 · Cited by 246 · see citing works
Plasma fibronectin promotes thrombus growth and stability in injured arterioles
Ni, H., Yuen, P. S. T., Papalia, J. M., Trevithick, J. E., Sakai, T., Fässler, R., Hynes, R. O., & Wagner, D. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628067100 · Cited by 225 · see citing works
Localized reduction of atherosclerosis in von Willebrand factor–deficient mice
Methia, N., André, P., Denis, C. V., Economopoulos, M., & Wagner, D. D. (2001) · Blood · doi:10.1182/blood.v98.5.1424 · Cited by 202 · see citing works
Defects in hemostasis in P-selectin-deficient mice
Subramaniam, M., Frenette, P. S., Saffaripour, S., Johnson, R., Hynes, R. O., & Wagner, D. D. (1996) · Blood · doi:10.1182/blood.v87.4.1238.bloodjournal8741238 · Cited by 197 · see citing works
Platelet-Endothelial Interactions in Inflamed Mesenteric Venules
Frenette, P. S., Moyna, C., Hartwell, D. W., Lowe, J. B., Hynes, R. O., & Wagner, D. D. (1998) · Blood · doi:10.1182/blood.v91.4.1318 · Cited by 188 · see citing works
Platelet‐Fibrinogen Interactions
BENNETT, J. S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03521.x · Cited by 187 · see citing works
A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V
Ramakrishnan, V., DeGuzman, F. R., Bao, M., Hall, S. W., Leung, L. L. K., & Phillips, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1823 · Cited by 170 · see citing works
Endothelial cells stimulated with tumor necrosis factor-alpha express varying amounts of tissue factor resulting in inhomogenous fibrin deposition in a native blood flow system. Effects of thrombin inhibitors.
Kirchhofer, D., Tschopp, T., Hadváry, P., & Baumgartner, H. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117202 · Cited by 153 · see citing works
Platelet-dependent primary hemostasis promotes selectin- and integrin- mediated neutrophil adhesion to damaged endothelium under flow conditions
Kuijper, P. H. M., Torres, H. I. G., van der Linden, J., Lammers, J. J., Sixma, J. J., Koenderman, L., & Zwaginga, J. J. (1996) · Blood · doi:10.1182/blood.v87.8.3271.bloodjournal8783271 · Cited by 152 · see citing works
Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and β2-Integrin
Κωνσταντόπουλος, Κ., Neelamegham, S., Burns, A. R., Hentzen, E. R., Kansas, G. S., Snapp, K. R., Berg, E. L., Hellums, J. D., Smith, C. W., McIntire, L. V., et al. (1998) · Circulation · doi:10.1161/01.cir.98.9.873 · Cited by 151 · see citing works
Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.
Marco, L. D., Girolami, A., Russell, S., & Ruggeri, Z. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111816 · Cited by 146 · see citing works
Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.
Holmbäck, K., Danton, M. J. S., Suh, T. T., Daugherty, C. C., & Degen, J. L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00962.x · Cited by 129 · see citing works
Blood cell dynamics in P-selectin-deficient mice
Johnson, R., Mayadas, T., Frenette, P. S., Mebius, R. E., Subramaniam, M., LaCasce, A. S., Hynes, R. O., & Wagner, D. D. (1995) · Blood · doi:10.1182/blood.v86.3.1106.bloodjournal8631106 · Cited by 121 · see citing works
Recombinant Soluble Form of PSGL-1 Accelerates Thrombolysis and Prevents Reocclusion in a Porcine Model
Kumar, A. F., Villani, M. P., Patel, U. K., Keith, J. C., & Schaub, R. G. (1999) · Circulation · doi:10.1161/01.cir.99.10.1363 · Cited by 115 · see citing works
Role of P-Selectin Cytoplasmic Domain in Granular Targeting In Vivo and in Early Inflammatory Responses
Hartwell, D. W., Mayadas, T. N., Berger, G., Frenette, P. S., Rayburn, H., Hynes, R. O., & Wagner, D. D. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1129 · Cited by 111 · see citing works
Tissue Factor, the Blood, and the Arterial Wall
Rauch, U. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(00)00049-9 · Cited by 98 · see citing works
Control of thrombus embolization and fibronectin internalization by integrin αIIbβ3 engagement of the fibrinogen γ chain
Ni, H., Papalia, J. M., Degen, J. L., & Wagner, D. D. (2003) · Blood · doi:10.1182/blood-2003-03-0850 · Cited by 92 · see citing works
Update on collagen receptor interactions in platelets: is the two-state model still valid?
Watson, O. B. S. (2000) · Platelets · doi:10.1080/09537100050129260 · Cited by 83 · see citing works
New and Effective Treatment of Experimentally Induced Venous Thrombosis with Anti-inflammatory rPSGL-Ig
Myers, D. D., Wrobleski, S. K., Londy, F. J., Fex, B. A., Hawley, A. E., Schaub, R. G., Greenfield, L. J., & Wakefield, T. W. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613014 · Cited by 77 · see citing works
Increased thrombogenesis and embolus formation in mice lacking glycoprotein V
Ni, H., Ramakrishnan, V., Ruggeri, Z. M., Papalia, J. M., Phillips, D. R., & Wagner, D. D. (2001) · Blood · doi:10.1182/blood.v98.2.368 · Cited by 73 · see citing works
Glanzmann thrombasthenia: new insights from an historical perspective.
Coller, B. S., Seligsohn, U., Peretz, H., & Newman, P. J. (1994) · PubMed · Cited by 73 · see citing works
Mechanisms Involved in Platelet Vessel Wall Interaction
Hawiger, J. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1642704 · Cited by 60 · see citing works
Elevated soluble P-selectin levels are associated with an increased risk of early adverse events in patients with presumed myocardial ischemia
Hillis, G. S., Terregino, C., Taggart, P., Killian, A. J., Zhao, N., Dalsey, W. C., & Mangione, A. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120303 · Cited by 54 · see citing works
Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models
Denis, C. V., Kwack, K., Saffaripour, S., Maganti, S., André, P., Schaub, R. G., & Wagner, D. D. (2001) · Blood · doi:10.1182/blood.v97.2.465 · Cited by 49 · see citing works
Propolypeptide of von Willebrand Factor Is a Novel Ligand for Very Late Antigen-4 Integrin
Isobe, T., Hisaoka, T., Shimizu, A., Okuno, M., Aimoto, S., Takada, Y., Saito, Y., & Takagi, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8447 · Cited by 36 · see citing works
Regulation of Murine Protein C Gene Expression In Vivo: Effects of Tumor Necrosis Factor-α, Interleukin-1, and Transforming Growth Factor-β
Shimokawa, T., Kojima, T., Loskutoff, D. J., Saito, H., & Yamamoto, K. (1999) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614379 · Cited by 35 · see citing works
Platelets, Platelet-Derived Growth Factor, Growth Control, and their Interactions with the Vascular Wall
Ross, R. (1985) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198500073-00022 · Cited by 21 · see citing works

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Platelet Activation and Atherothrombosis
Davì, G., & Patrono, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071014 · Cited by 2,135 · see citing works
Clinical Update: Cardiovascular Disease in Diabetes Mellitus
Wang, C. C. L., Hess, C. N., Hiatt, W. R., & Goldfine, A. B. (2016) · Circulation · doi:10.1161/circulationaha.116.022194 · Cited by 1,183 · see citing works
Reactive Oxygen Species
Krötz, F., Sohn, H., & Pohl, U. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000145574.90840.7d · Cited by 1,026 · see citing works
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells
Palumbo, J. S., Talmage, K. E., Massari, J. V., Jeunesse, C. M. L., Flick, M. J., Kombrinck, K. W., Jiroušková, M., & Degen, J. L. (2004) · Blood · doi:10.1182/blood-2004-06-2272 · Cited by 1,000 · see citing works
Bidirectional Relation Between Inflammation and Coagulation
Levi, M. M., van der Poll, T., & Buller, H. R. (2004) · Circulation · doi:10.1161/01.cir.0000131660.51520.9a · Cited by 942 · see citing works
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
Zindel, J., & Kubes, P. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032847 · Cited by 874 · see citing works
Adhesion Mechanisms in Platelet Function
Ruggeri, Z. M., & Mendolicchio, G. L. (2007) · Circulation Research · doi:10.1161/01.res.0000267878.97021.ab · Cited by 759 · see citing works
Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions
Davidovici, B. B., Sattar, N. A., Prinz, J. C., Puig, L., Emery, P., Barker, J. N., van de Kerkhof, P., Ståhle, M., Nestle, F. O., Girolomoni, G., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.103 · Cited by 713 · see citing works
Integrins: dynamic scaffolds for adhesion and signaling in platelets
Shattil, S. J., & Newman, P. J. (2004) · Blood · doi:10.1182/blood-2004-04-1257 · Cited by 600 · see citing works
Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization
Brill, A. G., Dashevsky, O., Rivo, J., Gozal, Y., & VARON, D. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.04.007 · Cited by 435 · see citing works
Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment
Li, R., He, Y., Zhang, S., Qin, J., & Wang, J. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2017.11.009 · Cited by 431 · see citing works
Platelets secrete stromal cell–derived factor 1α and recruit bone marrow–derived progenitor cells to arterial thrombi in vivo
Maßberg, S., Konrad, I., Schürzinger, K., Lorenz, M., Schneider, S., Zohlnhöfer, D., Hoppe, K., Schiemann, M., Kennerknecht, E., Sauer, S., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051772 · Cited by 418 · see citing works
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
Kisucka, J., Butterfield, C., Duda, D. G., Eichenberger, S. C., Saffaripour, S., Ware, J. L., Ruggeri, Z. M., Jain, R. K., Folkman, J., & Wagner, D. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510412103 · Cited by 360 · see citing works
miRSystem: An Integrated System for Characterizing Enriched Functions and Pathways of MicroRNA Targets
Lu, T., Lee, C., Tsai, M., Chiu, Y., Hsiao, C. K., Lai, L., & Chuang, E. Y.-Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042390 · Cited by 354 · see citing works
Journal of Clinical Medicine
(2020) · Journal of Clinical Medicine- Hue Central Hospital · doi:10.38103/jcmhch.2020.64 · Cited by 307 · see citing works
Platelets and innate immunity
Semple, J. W., & Freedman, J. J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0205-1 · Cited by 306 · see citing works
Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention
Zhu, W., Cheng, K. K. Y., Vanhoutte, P. M., Lam, K. S. L., & Xu, A. (2008) · Clinical Science · doi:10.1042/cs20070347 · Cited by 285 · see citing works
Clinical relevance of microparticles from platelets and megakaryocytes
Italiano, J. E., Mairuhu, A. T. A., & Flaumenhaft, R. C. (2010) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32833e77ee · Cited by 289 · see citing works
Platelets and Chemokines in Atherosclerosis
Weber, C. (2005) · Circulation Research · doi:10.1161/01.res.0000160077.17427.57 · Cited by 265 · see citing works
Platelet activation in obesity and metabolic syndrome
Santilli, F., Vazzana, N., Liani, R., Guagnano, M. T., & Davı̀, G. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00930.x · Cited by 261 · see citing works
Platelet Adhesion under Flow
Ruggeri, Z. M. (2009) · Microcirculation · doi:10.1080/10739680802651477 · Cited by 254 · see citing works
The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
Bergmeier, W., Piffath, C. L., Goerge, T., Cifuni, S. M., Ruggeri, Z. M., Ware, J. L., & Wagner, D. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608207103 · Cited by 235 · see citing works
Antiatherosclerotic and Antithrombotic Effects of Omega-3 Fatty Acids
Robinson, J. G., & Stone, N. J. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.12.026 · Cited by 207 · see citing works
Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non–ST-Segment Elevation Myocardial Infarction
Tardif, J., Tanguay, J., Wright, S. R., Duchatelle, V., Petroni, T., Grégoire, J. C., Ibrahim, R., Heinonen, T. M., Robb, S., Bertrand, O. F., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.003 · Cited by 206 · see citing works
Low-Dose Aspirin in Patients with Stable Cardiovascular Disease: A Meta-analysis
Berger, J. S., Brown, D., & Becker, R. C. (2008) · The American Journal of Medicine · doi:10.1016/j.amjmed.2007.10.002 · Cited by 202 · see citing works
Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies
Xu, X., Carrim, N., Neves, M. A. D., McKeown, T., Stratton, T. W., Coelho, R. M. P., Lei, X., Chen, P., Xu, J., Dai, X., et al. (2016) · Thrombosis Journal · doi:10.1186/s12959-016-0100-6 · Cited by 200 · see citing works
Platelet glycoprotein Ibα supports experimental lung metastasis
Jain, S., Zuka, M., Liu, J., Russell, S., Dent, J. A., Guerrero, J. A., Forsyth, J. S., Maruszak, B., Gartner, T. K., Felding‐Habermann, B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700625104 · Cited by 197 · see citing works
Signal-Dependent Protein Synthesis by Activated Platelets
Zimmerman, G. A., & Weyrich, A. S. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160218 · Cited by 193 · see citing works
New Links Between Inflammation and Thrombosis
Wagner, D. D. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166521.90532.44 · Cited by 191 · see citing works
Platelet–lymphocyte cross-talk
Li, N. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907615 · Cited by 185 · see citing works
Systemic inflammation as a risk factor for atherothrombosis
van Leuven, S. I., Franssen, R., Kastelein, J. J. P., Levi, M. M., Stroes, E. S. G., & Tak, P. P. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem202 · Cited by 179 · see citing works
Inflammation and hemostasis
Margetić, S. (2012) · Biochemia Medica · doi:10.11613/bm.2012.006 · Cited by 179 · see citing works
Olive Oil, the Mediterranean Diet, and Cardiovascular Health
Huang, C. L., & Sumpio, B. E. (2008) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2008.02.018 · Cited by 171 · see citing works
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes
Tjwa, M., Bellido‐Martín, L., Lin, Y., Lutgens, E., Plaisance, S., Bono, F., Delesque-Touchard, N., Hervé, C., Moura, R., Billiau, A., et al. (2007) · Blood · doi:10.1182/blood-2007-05-089565 · Cited by 162 · see citing works
The Pathogenesis of Adenomyosis vis-à-vis Endometriosis
Guo, S.-W. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020485 · Cited by 165 · see citing works
The Platelet Response to Tissue Injury
Eisinger, F., Patzelt, J., & Langer, H. F. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00317 · Cited by 156 · see citing works
Inflammation and haemostasis.
Margetić, S. (2012) · PubMed Central · Cited by 155 · see citing works
Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function
Gaur, M., Kamata, T., Wang, S., Moran, B., Shattil, S. J., & Leavitt, A. D. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01744.x · Cited by 153 · see citing works
Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection
McNicol, A., & Israels, S. J. (2008) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152908784533739 · Cited by 153 · see citing works
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Li, C., Li, J., Yan, L., Lang, S., Yougbaré, I., Zhu, G., Chen, P., & Ni, H. (2012) · Advances in Hematology · doi:10.1155/2012/384685 · Cited by 150 · see citing works
Aspirin Attenuates Platelet Activation and Immune Activation in HIV-1-Infected Subjects on Antiretroviral Therapy
O’Brien, M. P., Montenont, E., Hu, L., Nardi, M. A., Valdes, V., Merolla, M., Gettenberg, G., Cavanagh, K., Aberg, J. A., Bhardwaj, N., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31828a292c · Cited by 146 · see citing works
Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis
Barrett, T. J., Schlegel, M., Zhou, F. Y., Gorenchtein, M., Bolstorff, J., Moore, K. J., Fisher, E. A. A., & Berger, J. S. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax0481 · Cited by 144 · see citing works
D-dimer, P-selectin, and microparticles: Novel markers to predict deep venous thrombosis
Myers, D. D., Hawley, A. E., Longo, C. R., Henke, P. K., Guire, K. E., Schmaier, A. H., Wakefield, T. W., & Rectenwald, J. E. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-06-0426 · Cited by 144 · see citing works
VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection)
Wang, Y., Zhang, W., Zhang, Y., Yang, Y., Sun, L., Hu, S., Chen, J., Zhang, C., Zheng, Y. Z., Zhen, Y., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.580167 · Cited by 144 · see citing works
A meta-analysis of the risk of venous thromboembolism in inflammatory rheumatic diseases
Lee, J. J., & Pope, J. E. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0435-y · Cited by 142 · see citing works
Systemic inflammation in xenograft recipients precedes activation of coagulation
Ezzelarab, M. B., Ekser, B., Azimzadeh, A. M., Lin, C. C., Zhao, Y., Springman-Rodriguez, R., Echeverri, G. J., Iwase, H., Long, C. E., Hara, H., et al. (2014) · Xenotransplantation · doi:10.1111/xen.12133 · Cited by 141 · see citing works
Prevalence and Localization of Pulmonary Embolism in Unexplained Acute Exacerbations of COPD
Aleva, F. E., Voets, L. W. L. M., Simons, S. O., de Mast, Q., van der Ven, A. J. A. M., & Heijdra, Y. F. (2016) · CHEST Journal · doi:10.1016/j.chest.2016.07.034 · Cited by 145 · see citing works
Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence
Ding, D., Liu, X., Duan, J., & Guo, S.-W. (2015) · Human Reproduction · doi:10.1093/humrep/dev025 · Cited by 139 · see citing works
ADAMTS13 turns 3
Levy, G. G., Motto, D. G., & Ginsburg, D. (2005) · Blood · doi:10.1182/blood-2004-10-4097 · Cited by 136 · see citing works
Amicus or Adversary
Bozza, F. A., Shah, A. M., Weyrich, A. S., & Zimmerman, G. A. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0241tr · Cited by 133 · see citing works
Thermo-Induced Shape-Memory PEG-PCL Copolymer as a Dual-Drug-Eluting Biodegradable Stent
Yang, C.-S., Wu, H., Sun, J., Hsiao, H., & Wang, T. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am4032295 · Cited by 133 · see citing works
Blood coagulation-dependent inflammation. Coagulation-dependent inflammation and inflammation-dependent thrombosis
Strukova, S. M. (2006) · Frontiers in bioscience · doi:10.2741/1780 · Cited by 133 · see citing works
Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004
Berger, J. S., Eraso, L. H., Xie, D., Sha, D., & Mohler, E. R. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.09.010 · Cited by 130 · see citing works
Adiponectin as a potential biomarker of vascular disease
Mohammadi, S., Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Fallah, P., & Bazi, Z. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s48753 · Cited by 129 · see citing works
A new role in hemostasis for the adhesion receptor P-selectin
Cambien, B., & Wagner, D. D. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.02.007 · Cited by 129 · see citing works
Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets
Scull, C. M., Hays, W. D., & Fischer, T. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-53 · Cited by 125 · see citing works
Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics
Zhu, L., Zhong, Y., Wu, S., Yan, M., Cao, Y., Mou, N., Wang, G., Sun, D., & Wu, W. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100228 · Cited by 125 · see citing works
What Can Proteomics Tell Us About Platelets?
Burkhart, J. M., Gambaryan, S. P., Watson, S. P., Jurk, K., Walter, U., Sickmann, A., Heemskerk, J. W. M., & Zahedi, R. P. (2014) · Circulation Research · doi:10.1161/circresaha.114.301598 · Cited by 122 · see citing works
Venous and arterial thromboembolic events in adalimumab‐treated patients with antiadalimumab antibodies: A case series and cohort study
Korswagen, L.-A., Bartelds, G. M., Krieckaert, C. L. M., Turkstra, F., Nurmohamed, M. T., van Schaardenburg, D., Wijbrandts, C. A., Tak, P. P., Lems, W. F., Dijkmans, B. A. C., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30209 · Cited by 121 · see citing works
Platelet activation in patients with psoriasis: Increased plasma levels of platelet-derived microparticles and soluble P-selectin
Tamagawa‐Mineoka, R., Katoh, N., & Kishimoto, S. (2009) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.06.053 · Cited by 121 · see citing works
Platelets prevent IFN-α/β-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
Iannacone, M., Sitia, G., Isogawa, M., Whitmire, J., Marchese, P., Chisari, F., Ruggeri, Z., & Guidotti, L. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0711200105 · Cited by 117 · see citing works
Proteomics of the TRAP-induced platelet releasate
Piersma, S. R., Broxterman, H. J., Kapci, M., de Haas, R. R., Hoekman, K., Verheul, H. M. W., & Jiménez, C. R. (2008) · Journal of Proteomics · doi:10.1016/j.jprot.2008.10.009 · Cited by 119 · see citing works
Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
Xu, X., Wang, Y., Adili, R., Ju, L. A., Spring, C. M., Jin, J. W., Yang, H., Neves, M. A. D., Chen, P., Yang, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05806-0 · Cited by 119 · see citing works
The association between metabolic syndrome components and the development of atherosclerosis
Aboonabi, A., Meyer, R. R., & Singh, I. (2019) · Journal of Human Hypertension · doi:10.1038/s41371-019-0273-0 · Cited by 121 · see citing works
Platelets in Atherothrombosis
Vorchheimer, D. A., & Becker, R. C. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.1.59 · Cited by 119 · see citing works
CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets
Khandoga, A., Hanschen, M., Kessler, J. S., & Krombach, F. (2006) · Hepatology · doi:10.1002/hep.21017 · Cited by 118 · see citing works
Enhanced peripheral thrombogenicity after lung inflammation is mediated by platelet–leukocyte activation: role of P‐selectin
Nemmar, A., Hoet, P., Vandervoort, P., Dinsdale, D. D., Nemery, B., & Hoylaerts, M. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02557.x · Cited by 109 · see citing works
Nutrigenetics and nutraceuticals: the next wave riding on personalized medicine
Subbiah, M. T. R. (2007) · Translational research · doi:10.1016/j.trsl.2006.09.003 · Cited by 109 · see citing works
Fibrin(ogen)-α M β 2 Interactions Regulate Leukocyte Function and Innate Immunity In Vivo
Flick, M. J., Du, X., & Degen, J. L. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901104 · Cited by 107 · see citing works
Platelets and Megakaryocytes Contain Functional Nuclear Factor-κB
Spinelli, S. L., Casey, A. E., Pollock, S. J., Gertz, J. M., McMillan, D. H., Narasipura, S. D., Mody, N. A., King, M. R., Maggirwar, S. B., Francis, C. W., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.197343 · Cited by 104 · see citing works
Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis
Eduardo Fuentes, Q., Francisco Fuentes, Q., Andrés, V., Pello, Ó. M., de Mora, J. F., & Palomo, I. F. (2012) · Platelets · doi:10.3109/09537104.2012.690113 · Cited by 104 · see citing works
HBV pathogenesis in animal models: Recent advances on the role of platelets
Iannacone, M., Sitia, G., Ruggeri, Z. M., & Guidotti, L. G. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.007 · Cited by 101 · see citing works
The decellularized porcine heart valve matrix in tissue engineering
Kasimir, M., Weigel, G., Sharma, J., Rieder, E., Seebacher, G., Wolner, E., & Simon, P. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-01-0025 · Cited by 101 · see citing works
A new role for the A2b adenosine receptor in regulating platelet function
Yang, D., CHEN, H., Koupenova, M., Carroll, S. H., Eliades, A., Freedman, J. E., Toselli, P. A., & Ravid, K. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03769.x · Cited by 100 · see citing works
15-deoxy-Δ12,14-PGJ2 enhances platelet production from megakaryocytes
O'Brien, J. J., Spinelli, S. L., Tober, J. M., Blumberg, N., Francis, C. W., Taubman, M. B., Palis, J., Seweryniak, K. E., Gertz, J. M., & Phipps, R. P. (2008) · Blood · doi:10.1182/blood-2008-05-158535 · Cited by 99 · see citing works
Platelet–neutrophil interactions under thromboinflammatory conditions
Li, J., Kim, K., Barazia, A., Tseng, A., & Cho, J. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1845-y · Cited by 95 · see citing works
Peroxisome proliferator-activated receptor γ and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles
Spinelli, S. L., Pollock, S. J., Murant, T. I., O'Brien, J. J., Blumberg, N., Francis, C. W., Taubman, M. B., Ray, D. M., & Phipps, R. P. (2007) · Thrombosis and Haemostasis · doi:10.1160/th07-05-0328 · Cited by 94 · see citing works
Primary Platelet Adhesion Receptors
Yip, J., Shen, Y., Berndt, M. C., & Andrews, R. K. (2005) · IUBMB Life · doi:10.1080/15216540500078962 · Cited by 92 · see citing works
Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis
Kisucka, J., Chauhan, A. K., Zhao, B., Patten, I. S., Yesilaltay, A., Krieger, M., & Wagner, D. D. (2009) · Blood · doi:10.1182/blood-2008-10-186650 · Cited by 91 · see citing works
Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis*
Kinasewitz, G. T., Zein, J., Lee, G. L., Nazir, S. A., & Taylor, F. B. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000181296.53204.de · Cited by 91 · see citing works
Fructus Gardenia ( Gardenia jasminoides J. Ellis) phytochemistry, pharmacology of cardiovascular, and safety with the perspective of new drugs development
Liu, H., Chen, Y., Li, F., & Zhang, H. (2012) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2012.723203 · Cited by 90 · see citing works
The Fatal Circle of NETs and NET-Associated DAMPs Contributing to Organ Dysfunction
Block, H., Rossaint, J., & Zarbock, A. (2022) · Cells · doi:10.3390/cells11121919 · Cited by 90 · see citing works
Thromboinflammation: From Atherosclerosis to COVID-19
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Aggrey, A., Srivastava, K., Ture, S. K., Field, D. J., & Morrell, C. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202672 · Cited by 87 · see citing works
Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells
Hao, D., Fan, Y., Xiao, W., Liu, R., Pivetti, C. D., Walimbe, T., Guo, F., Zhang, X., Farmer, D. L., Wang, F., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.03.005 · Cited by 85 · see citing works
Enhanced thrombin formation and fibrinolysis during acute Puumala hantavirus infection
Laine, O., Mäkelä, S., Mustonen, J. T., Huhtala, H., Szántó, T., Vaheri, A. I., Lassila, R., & Joutsi‐Korhonen, L. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2010.05.025 · Cited by 85 · see citing works
Elevated platelet and leukocyte response to oral bacteria in periodontitis
Nicu, E. A., van der Velden, U., Nieuwland, R., Everts, V. E., & Loos, B. G. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.03219.x · Cited by 83 · see citing works
Surface Modification with Dopamine and Heparin/Poly- l -Lysine Nanoparticles Provides a Favorable Release Behavior for the Healing of Vascular Stent Lesions
Liu, T., Zeng, Z., Liu, Y., Wang, J., Maitz, M. F., Wang, Y., Liu, S., Chen, J., & Huang, N. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am5015309 · Cited by 83 · see citing works
The garlic component, allicin, prevents disease caused by Aeromonas hydrophila in rainbow trout, Oncorhynchus mykiss (Walbaum)
Nya, E., Dawood, Z., & Austin, B. P. (2010) · Journal of Fish Diseases · doi:10.1111/j.1365-2761.2009.01121.x · Cited by 83 · see citing works
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling
Nishimura, S., Manabe, I., Nagasaki, M., Kakuta, S., Iwakura, Y., Takayama, N., Ooehara, J., Otsu, M., Kamiya, A., Petrich, B. G., et al. (2011) · Blood · doi:10.1182/blood-2011-09-381400 · Cited by 82 · see citing works
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
Pagé, M., Thomson, G. J. A., Nunes, J. M., Engelbrecht, A., Nell, T. A., de Villiers, W. J. S., de Beer, M. C., Engelbrecht, L., Kell, D. B., & Pretorius, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-39056-x · Cited by 81 · see citing works
Effects of the P‐Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention According to Timing of Infusion: Insights From the SELECT‐ACS Trial
Stähli, B. E., Gebhard, C., Duchatelle, V., Cournoyer, D., Petroni, T., Tanguay, J., Robb, S., Mann, J., Guertin, M., Wright, R. S., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.004255 · Cited by 81 · see citing works
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Habets, K. L. L., Trouw, L. A., Levarht, E. W. N., Korporaal, S. J. A., Habets, P. A. M., de Groot, P. G., Huizinga, T. W. J., & Toes, R. E. M. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0665-7 · Cited by 79 · see citing works
Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin
Huang, Y., Cao, S., Zhang, Q., Zhang, H., Fan, Y., Qiu, F., & Kang, N. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.03.030 · Cited by 79 · see citing works
Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome
Oylumlu, M., Yıldız, A., Oylumlu, M., Yüksel, M., Polat, N., Bilik, M. Z., Akyüz, A., Aydın, M., Acet, H., & Soydinç, S. (2014) · The Anatolian Journal of Cardiology · doi:10.5152/akd.2014.5366 · Cited by 78 · see citing works
Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy
Alimohammadvand, S., Zenjanab, M. K., Mashinchian, M., Shayegh, J., & Jahanban‐Esfahlan, R. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116951 · Cited by 79 · see citing works
Platelet Recruitment to the Inflamed Glomerulus Occurs via an αIIbβ3/GPVI-Dependent Pathway
Devi, S., Kuligowski, M., Kwan, R. Y. Q., Westein, E., Jackson, S. P., Kitching, A. R., & Hickey, M. J. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091143 · Cited by 77 · see citing works
Prediction of Preeclampsia By First Trimester Combined Test and Simple Complete Blood Count Parameters
Kırbaş, A. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/15397.6833 · Cited by 76 · see citing works
Endothelium–platelet interactions in inflammatory lung disease
Tabuchi, A., & Kuebler, W. M. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.06.004 · Cited by 75 · see citing works
Platelet-Rich Preparations to Improve Healing. Part I: Workable Options for Every Size Practice
Davis, V. L., Abukabda, A. B., Radio, N. M., Witt‐Enderby, P. A., Clafshenkel, W. P., Cairone, J. V., & Rutkowski, J. L. (2014) · Journal of Oral Implantology · doi:10.1563/aaid-joi-d-12-00104 · Cited by 75 · see citing works

Authors: Wagner, D. D., & Burger, P. C.
Affiliations: Harvard University (US)
ORCID: Wagner, Denisa D.
Burger, Peter C.
Venue: Arteriosclerosis Thrombosis and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-12
Volume: 23
Issue: 12
Pages: 2131-2137
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/01.atv.0000095974.95122.ec
OpenAlex: W2169304723
Cited by: 570
References: 91
Citations by year: 2026: 11 · 2025: 10 · 2024: 17 · 2023: 18 · 2022: 29 · 2021: 19 · 2020: 23 · 2019: 21 · 2018: 21 · 2017: 18 · 2016: 35 · 2015: 30 · 2014: 40 · 2013: 28 · 2012: 32
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
National Institutes of Health
National Heart, Lung, and Blood Institute (R01-HL-53756, P01 HL 56949, R37HL041002, P01HL056949, R37 HL 41002, R01HL053756)
Topics: Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: platelets, inflammation, thrombosis, hemostasis, platelet function
MeSH terms: Animals, Blood Platelets, Endothelium, Vascular, Humans, Inflammation, Thrombosis

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