The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.
Open accessAbstract
Although loss of cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl- channel function is common to all epithelia in cystic fibrosis (CF) patients, the severity of disease varies in different organs. We hypothesized that differences in disease severity in CF relate to the expression of an "alternative" plasma membrane Cl- conductance. In CF mice [Cftr(-/-); mice homozygous for Ser-489 to Xaa mutation], which do not express cAMP CFTR-mediated Cl- secretion, we surveyed organs that exhibit a range of disease severity for a Ca(2+)-mediated apical membrane epithelial Cl- conductance. This alternative conductance (Cl-a) was detected in epithelia of organs from CF mice that exhibit a mild disease phenotype (airway, pancreas) but not in epithelia with a severe phenotype (small, large intestine). We conclude that (i) there is an intracellular Ca(2+)-regulated Cl- conductance that is molecularly distinct from CFTR; and (ii) the level of expression of this alternative Cl- conductance in the epithelium is an important determinant of the severity of organ-level disease in CF.
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Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Hery-Arnaud, G., Le Berre, R., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992
The Metabolic Basis of Inherited Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-5-389_2 · Cited by 3,983
Cheng, S. H., Gregory, R. J., Marshall, J., Paul, S., Souza, D. W., White, G. A., O'Riordan, C. R., & Smith, A. E. (1990) · Cell · doi:10.1016/0092-8674(90)90148-8 · Cited by 1,792
Physiology of the Gastrointestinal Tract.
(1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-1-131_1 · Cited by 1,673
Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity
Anderson, M. P., Gregory, R. J., Thompson, S., Souza, D. W., Paul, S., Mulligan, R. C., Smith, A. E., & Welsh, M. J. (1991) · Science · doi:10.1126/science.1712984 · Cited by 1,137
Bear, C. E., Li, C., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M., & Riordan, J. R. (1992) · Cell · doi:10.1016/0092-8674(92)90155-6 · Cited by 945
An Animal Model for Cystic Fibrosis Made by Gene Targeting
Snouwaert, J. N., Brigman, K. K., Latour, A. M., Malouf, N. N., Boucher, R. C., Smithies, O., & Koller, B. H. (1992) · Science · doi:10.1126/science.257.5073.1083 · Cited by 918
Self-citationKnowles, M. R., Clarke, L. L., & Boucher, R. C. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108223250802 · Cited by 491
Self-citationDefective acidification of intracellular organelles in cystic fibrosis
Barasch, J., Kiss, B., Prince, A., Saiman, L., Gruenert, D., & AI-Awqati, Q. (1991) · Nature · doi:10.1038/352070a0 · Cited by 490
Anderson, M. P., & Welsh, M. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6003 · Cited by 367
Cited by
Cystic fibrosis genetics: from molecular understanding to clinical application
Cutting, G. R. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3849 · Cited by 965
Electrolyte transport in the mammalian colon: mechanisms and implications for disease
Kunzelmann, K., & Mall, M. (2002) · Physiological Reviews · doi:10.1152/physrev.00026.2001 · Cited by 655
Rozmahe, R., Wilschanski, M., Matin, A., Plyte, S., Oliver, M., Auerbach, W., Moore, A., Forstner, J., Durie, P., Nadeau, J., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-280 · Cited by 386
Seidler, U., Blumenstein, I., Kretz, A., Viellard‐Baron, D., Rossmann, H., Colledge, W. H., Evans, M., Ratcliff, R., & Gregor, M. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.411bb.x · Cited by 255
Metadata
- Authors
- Clarke, L. L., Grubb, B. R., Yankaskas, J. R., Cotton, C. U., McKenzie, A., & Boucher, R. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-01-18
- Volume
- 91
- Issue
- 2
- Pages
- 479-483
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012280093
- Cited by
- 342
- References
- 18
- FWCI
- 21.86
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. https://app.cochat.ai/papers/10.1073/pnas.91.2.479
- The paper
- Clarke, L. L., Grubb, B. R., Yankaskas, J. R., Cotton, C. U., McKenzie, A., & Boucher, R. C. (1994). Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.2.479
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
