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Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Open accessAbstract
Urate oxidase, or uricase (EC 1.7.3.3), is a purine metabolic enzyme that catalyzes the conversion of uric acid to allantoin in most mammals except humans and certain other primates. The loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia, a metabolic disturbance that can lead to gouty arthritis and renal stones. To create a mouse model for hyperuricemia and gout, and to address the question of whether urate oxidase is essential in lower mammalian species, we have disrupted the urate oxidase gene in the mouse by homologous recombination in embryonic stem cells. Unlike the human situation, urate oxidase deficiency in mice causes pronounced hyperuricemia and urate nephropathy. More than half of the mutant mice died before 4 weeks of age, indicating that urate oxidase is essential in mice. These mutant mice may also serve as animal models for hyperuricemia and its related nephropathy in humans.
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Citations
Cited by
Pacher, P., Nivorozhkin, A., & Szabó, C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.1.6 · Cited by 1,218
Cantor, J. R., Abu-Remaileh, M., Kanarek, N., Freinkman, E., Gao, X., Louissaint, A., Lewis, C. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.03.023 · Cited by 616
Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis
Gasse, P., Riteau, N., Charron, S., Girre, S., Fick, L., Pétrilli, V., Tschopp, J., Lagente, V., Quesniaux, V. F. J., Ryffel, B., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1274oc · Cited by 410
Uric acid, hyperuricemia and vascular diseases
Jin, M. (2012) · Frontiers in Bioscience · doi:10.2741/3950 · Cited by 406
Preitner, F., Bonny, O., Laverrière, A., Rotman, S., Firsov, D., Da Costa, A., Metref, S., & Thorens, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904411106 · Cited by 284
Metadata
- Authors
- Wu, X., Wakamiya, M., Vaishnav, S., Geske, R., Montgomery, C., Jones, P., Bradley, A., & Caskey, C. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-01-18
- Volume
- 91
- Issue
- 2
- Pages
- 742-746
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968290904
- Cited by
- 291
- References
- 0
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, X., Wakamiya, M., Vaishnav, S., Geske, R., Montgomery, C., Jones, P., Bradley, A., & Caskey, C. T. (1994). Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.2.742
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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