Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
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The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades. More recent data indicate that XO also plays an important role in various forms of ischemic and other types of tissue and vascular injuries, inflammatory diseases, and chronic heart failure. Allopurinol and its active metabolite oxypurinol showed considerable promise in the treatment of these conditions both in experimental animals and in small-scale human clinical trials. Although some of the beneficial effects of these compounds may be unrelated to the inhibition of the XO, the encouraging findings rekindled significant interest in the development of additional, novel series of XO inhibitors for various therapeutic indications. Here we present a critical overview of the effects of XO inhibitors in various pathophysiological conditions and also review the various emerging therapeutic strategies offered by this approach.
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Peroxynitrite reacts relatively slowly in comparison with other RNS with many biomolecules, including metal centers, proteins, DNA, and lipids.
“Despite its rapid rate of formation, peroxynitrite reacts relatively slowly in comparison with other RNS, with many biomolecules, including metal centers, proteins, DNA, and lipids (78, 526, 709).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [709]
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McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952 · see citing works
Oxygen-Derived Free Radicals in Postischemic Tissue Injury
Epstein, F. H., & McCord, J. M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198501173120305 · Cited by 5,399 · see citing works
Ames, B. N., Cathcart, R., Schwiers, E., & Hochstein, P. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6858 · Cited by 2,915 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
The mononuclear molybdenum enzymes
Hille, R., Hall, J., & Basu, P. (2014) · Chemical Reviews · doi:10.1021/cr400443z · Cited by 1,738 · see citing works
The Mononuclear Molybdenum Enzymes
Hille, R. (1996) · Chemical Reviews · doi:10.1021/cr950061t · Cited by 1,501 · see citing works
Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout
Becker, M. A., Schumacher, H. R., Wortmann, R. L., MacDonald, P. A., Eustace, D., Palo, W. A., Streit, J., & Joseph-Ridge, N. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050373 · Cited by 1,357 · see citing works
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298 · see citing works
Superoxide radicals in feline intestinal ischemia
Granger, D. N., Rutili, G., & McCord, J. M. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90648-x · Cited by 1,212 · see citing works
The Reduction of Cytochrome c by Milk Xanthine Oxidase
McCord, J. M., & Fridovich, I. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91929-0 · Cited by 1,205 · see citing works
Hyperuricemia induces endothelial dysfunction
Khosla, U. M., Zharikov, S. I., Finch, J., Nakagawa, T., Roncal, C., Mu, W., Krotova, K. Y., Block, E. R., Prabhakar, S. S., & Johnson, R. J. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00273.x · Cited by 1,197 · see citing works
Berry, C. E., & Hare, J. M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055913 · Cited by 925 · see citing works
Structure and function of xanthine oxidoreductase: where are we now?
Harrison, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00956-5 · Cited by 787 · see citing works
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works
Does superoxide underlie the pathogenesis of hypertension?
Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., & Inoue, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10045 · Cited by 746 · see citing works
Ischemic injury in the cat small intestine: Role of superoxide radicals
Parks, D. A., Bulkley, G. B., Granger, D. N., Hamilton, S. R., & McCord, J. M. (1982) · Gastroenterology · doi:10.1016/0016-5085(82)90115-9 · Cited by 741 · see citing works
Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Nishino, T., & Pai, E. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10723 · Cited by 733 · see citing works
Xanthine oxidase and neutrophil infiltration in intestinal ischemia
Grisham, M. B., Hernandez, L. A., & Granger, D. N. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.4.g567 · Cited by 722 · see citing works
Peroxynitrite-mediated oxidation of dihydrorhodamine 123
Kooy, N. W., Royall, J. A., Ischiropoulos, H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90138-4 · Cited by 720 · see citing works
The purine path to chemotherapy
Elion, G. B. (1989) · Science · doi:10.1126/science.2649979 · Cited by 687 · see citing works
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
van der Loo, B., Labugger, R., Skepper, J. N., Bachschmid, M. M., Kilo, J., Powell, J. M., Palacios‐Callender, M., Erusalimsky, J. D., Quaschning, T., Maliñski, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1731 · Cited by 674 · see citing works
Xanthine oxidase as a source of free radical damage in myocardial ischemia
CHAMBERS, D., PARKS, D., PATTERSON, G., ROY, R., MCCORD, J., YOSHIDA, S., PARMLEY, L., & DOWNEY, J. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80017-1 · Cited by 672 · see citing works
Kuypers, H. G. J. M., & Maisky, V. A. (1975) · Neuroscience Letters · doi:10.1016/0304-3940(75)90004-x · Cited by 607 · see citing works
Anker, S. D., Doehner, W., Rauchhaus, M., Sharma, R., Francis, D., Knosalla, C., Davos, C. H., Cicoira, M., Shamim, W., Kemp, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065637.10517.a0 · Cited by 593 · see citing works
Hooper, D. C., Spitsin, S. V., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., & Koprowski, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.675 · Cited by 569 · see citing works
Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
Csiszár, A., Ungvari, Z. I., Edwards, J. G., Kaminski, P. M., Wolin, M. S., Koller, Á., & Kaley, G. (2002) · Circulation Research · doi:10.1161/01.res.0000020401.61826.ea · Cited by 565 · see citing works
Doehner, W., Schoene, N., Rauchhaus, M., Leyva‐Leon, F., Pavitt, D. V., Reaveley, D. A., Schuler, G. C., Coats, A. J. S., Anker, S. D., & Hambrecht, R. (2002) · Circulation · doi:10.1161/01.cir.0000017502.58595.ed · Cited by 565 · see citing works
Allopurinol Improves Endothelial Dysfunction in Chronic Heart Failure
Farquharson, C. A. J., Butler, R., Hill, A., Belch, J. J. F., & Struthers, A. D. (2002) · Circulation · doi:10.1161/01.cir.0000022140.61460.1d · Cited by 504 · see citing works
Millar, T. M., Stevens, C. R., Benjamin, N., Eisenthal, R., Harrison, R., & Blake, D. R. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00430-x · Cited by 491 · see citing works
Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas
Romão, M. J., Archer, M., Moura, I., Moura, J. J. G., LeGall, J., Engh, R. A., Schneider, M., Hof, P., & Huber, R. (1995) · Science · doi:10.1126/science.270.5239.1170 · Cited by 480 · see citing works
Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension
Butler, R., Morris, A. D., Belch, J. J. F., Hill, A., & Struthers, A. D. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.746 · Cited by 463 · see citing works
McNally, J. S., Davis, M. E., Giddens, D. P., Saha, A., Hwang, J., Dikalov, S., Jo, H., & Harrison, D. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00515.2003 · Cited by 461 · see citing works
Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure
Ferdinandy, P., Danial, H., Ambrus, I., Rothery, R. A., & Schulz, R. (2000) · Circulation Research · doi:10.1161/01.res.87.3.241 · Cited by 457 · see citing works
Terkeltaub, R. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmcp030733 · Cited by 456 · see citing works
Serum Uric Acid and Cardiovascular Events in Successfully Treated Hypertensive Patients
Alderman, M. H., Cohen, H. W., Madhavan, S., & Kivlighn, S. D. (1999) · Hypertension · doi:10.1161/01.hyp.34.1.144 · Cited by 441 · see citing works
Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy
Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436 · see citing works
An Extremely Potent Inhibitor of Xanthine Oxidoreductase
Okamoto, K., Eger, B. T., Nishino, T., Kondo, S., Pai, E. F., & Nishino, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208307200 · Cited by 434 · see citing works
Wallace, K. L., Riedel, A. A., Joseph‐Ridge, N., & Wortmann, R. L. (2004) · PubMed · Cited by 426 · see citing works
Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase
Godber, B. L. J., Doel, J. J., Sapkota, G. P., Blake, D. R., Stevens, C. R., Eisenthal, R., & Harrison, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7757 · Cited by 411 · see citing works
Sorescu, D., & Griendling, K. K. (2002) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2002.00717.x · Cited by 406 · see citing works
Vascular NADPH oxidases: molecular mechanisms of activation
Brandes, R. P., & Kreuzer, J. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.007 · Cited by 396 · see citing works
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391 · see citing works
Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes
Desco, C., Asensi, M. A., Márquez, R., Martínez-Valls, J. F., Vento, M., Pallardó, F. V., Sastre, J., & Viña, J. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1118 · Cited by 390 · see citing works
Progress Towards the Discovery of Xanthine Oxidase Inhibitors
Borges, F., Fernandes, E. G. R., & Roleira, F. M. F. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023371229 · Cited by 373 · see citing works
White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367 · see citing works
Oxidative Stress, Metabolism of Ethanol and Alcohol-Related Diseases
Zima, T., Fialová, L., Mestek, O., Kalousová, M., Crkovska, J., Malbohan, I. M., Štípek, S., Mikulikova, L., & Popov, P. (2001) · Journal of Biomedical Science · doi:10.1007/bf02255972 · Cited by 351 · see citing works
Aberrant inflammation and resistance to glucocorticoids in Annexin 1 −/− Mouse
Hannon, R., Croxtall, J. D., Getting, S. J., Roviezzo, F., Yona, S., Paul‐Clark, M. J., Gavins, F. N. E., Perretti, M., Morris, J. F., Buckingham, J. C., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0239fje · Cited by 351 · see citing works
Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.
Engerson, T. D., McKelvey, T. G., Rhyne, D. B., Boggio, E. B., Snyder, S. J., & Jones, H. P. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112990 · Cited by 350 · see citing works
Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase
Takano, Y., Hase-Aoki, K., Horiuchi, H., Zhao, L., Kasahara, Y., Kondo, S., & Becker, M. A. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.10.031 · Cited by 336 · see citing works
Akaike, T., Ando, M., Oda, T., Doi, T., Ijiri, S., Araki, S., & Maeda, H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114499 · Cited by 333 · see citing works
Pacher, P., Obrosova, I. G., Mabley, J. G., & Szabó, C. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053363207 · Cited by 331 · see citing works
Self-citationIschemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals
Parks, D. A., & Granger, D. N. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.245.2.g285 · Cited by 322 · see citing works
Allopurinol Hypersensitivity Syndrome: A Review
Arellano, F., & Sacristán, J. A. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700317 · Cited by 321 · see citing works
Knight, T. R. (2001) · Toxicological Sciences · doi:10.1093/toxsci/62.2.212 · Cited by 311 · see citing works
Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Diseases
Lieber, C. S. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61001-7 · Cited by 299 · see citing works
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Wu, X., Wakamiya, M., Vaishnav, S., Geske, R. S., Montgomery, C. A., Jones, P., Bradley, A., & Caskey, C. T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.742 · Cited by 292 · see citing works
Reperfusion injury after intestinal ischemia
Schoenberg, M. H., & Beger, H. G. (1993) · Critical Care Medicine · doi:10.1097/00003246-199309000-00023 · Cited by 288 · see citing works
Uric acid in chronic heart failure: a marker of chronic inflammation
Leyva, F. (1998) · European Heart Journal · doi:10.1053/euhj.1998.1188 · Cited by 287 · see citing works
Okamoto, K., Matsumoto, K., Hille, R., Eger, B. T., Pai, E. F., & Nishino, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400973101 · Cited by 286 · see citing works
Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation
Parks, D. A., Williams, T. K., & Beckman, J. S. (1988) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1988.254.5.g768 · Cited by 282 · see citing works
Pacher, P., Liaudet, L., Bai, P., Mabley, J. G., Kaminski, P. M., Virág, L., Deb, A., Szabó, É., Ungvari, Z. I., Wolin, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000048192.52098.dd · Cited by 279 · see citing works
Self-citationBinding of Xanthine Oxidase to Vascular Endothelium
Houston, M., Estévez, Á. G., Chumley, P. H., Aslan, M., Marklund, S. L., Parks, D. A., & Freeman, B. Α. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4985 · Cited by 271 · see citing works
MANNING, A. S., COLTART, D. J., & Hearse, D. J. (1984) · Circulation Research · doi:10.1161/01.res.55.4.545 · Cited by 263 · see citing works
Xanthine oxidase activity associated with arterial blood pressure in spontaneously hypertensive rats
Suzuki, H., DeLano, F. A., Parks, D. A., Jamshidi, N., Granger, D. N., Ishii, H., Suematsu, M., Zweifach, B. W., & Schmid‐Schönbein, G. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4754 · Cited by 262 · see citing works
Granger, D. N., McCord, J. M., Parks, D. A., & Höllwarth, M. E. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90078-8 · Cited by 257 · see citing works
Kramer, H., & Curhan, G. C. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.33911 · Cited by 254 · see citing works
Zhang, Z., Naughton, D., Winyard, P. G., Benjamin, N., Blake, D. R., & Symons, M. C. R. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9226 · Cited by 246 · see citing works
Cardillo, C., Kilcoyne, C. M., Cannon, R. O., Quyyumi, A. A., & Panza, J. A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.57 · Cited by 246 · see citing works
Ekelund, U. E. G., Harrison, R. W., Shokek, O., Thakkar, R. N., Tunin, R. S., Senzaki, H., Kass, D. A., Marbán, E., & Hare, J. M. (1999) · Circulation Research · doi:10.1161/01.res.85.5.437 · Cited by 239 · see citing works
Nitrosative stress and pharmacological modulation of heart failure
Pacher, P., Schulz, R., Liaudet, L., & Szabó, C. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.04.003 · Cited by 237 · see citing works
Self-citationReduction of Perinatal Hypoxic-Ischemic Brain Damage with Allopurinol
Palmer, C., Vannucci, R. C., & Towfighi, J. (1990) · Pediatric Research · doi:10.1203/00006450-199004000-00003 · Cited by 237 · see citing works
Role of oxygen free radicals in shock, ischemia, and organ preservation.
Parks, D. A., Bulkley, G. B., & Granger, D. N. (1983) · PubMed · Cited by 236 · see citing works
Reperfusion injury pathophysiology in sickle transgenic mice
Osarogiagbon, U. R., Choong, S., Belcher, J. D., Vercellotti, G. M., Paller, M. S., & Hebbel, R. P. (2000) · Blood · doi:10.1182/blood.v96.1.314 · Cited by 234 · see citing works
Uric acid: role in cardiovascular disease and effects of losartan
Alderman, M. H., & Viswanathan‐Aiyer, K. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125002982 · Cited by 231 · see citing works
Substrate Control of Free Radical Generation from Xanthine Oxidase in the Postischemic Heart
Xia, Y., & Zweier, J. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18797 · Cited by 229 · see citing works
Khan, S. A., Lee, K., Minhas, K. M., González, D. R., Raju, S. V. Y., Tejani, A. D., Li, D., Berkowitz, D. E., & Hare, J. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404136101 · Cited by 227 · see citing works
Meneshian, A., & Bulkley, G. B. (2002) · Microcirculation · doi:10.1038/sj.mn.7800136 · Cited by 225 · see citing works
Xanthine Oxidase Inhibition Reverses Endothelial Dysfunction in Heavy Smokers
Guthikonda, S., Sinkey, C., Barenz, T., & Haynes, W. G. (2003) · Circulation · doi:10.1161/01.cir.0000046448.26751.58 · Cited by 225 · see citing works
Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk
Mercuro, G. G., Vitale, C., Cerquetani, E., Zoncu, S., Deidda, M., Fini, M., & Rosano, G. M. C. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.06.032 · Cited by 223 · see citing works
Management of Acute and Chronic Gouty Arthritis
Schlesinger, N. (2004) · Drugs · doi:10.2165/00003495-200464210-00003 · Cited by 220 · see citing works
Oxygen free radicals and contrast nephropathy
Katholi, R., Woods, W. T., Taylor, G., Deitrick, C. L., Womack, K. A., Katholi, C. R., & McCann, W. P. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9669426 · Cited by 215 · see citing works
Physiological Roles of Xanthine Oxidoreductase
Harrison, R. (2004) · Drug Metabolism Reviews · doi:10.1081/dmr-120037569 · Cited by 215 · see citing works
Novel NAD(P)H oxidases in the cardiovascular system: Table 1
Griendling, K. K. (2004) · Heart · doi:10.1136/hrt.2003.029397 · Cited by 213 · see citing works
Nishino, T. (1994) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124480 · Cited by 212 · see citing works
Xanthine oxidoreductase is central to the evolution and function of the innate immune system
Vorbach, C., Harrison, R., & Capecchi, M. R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00237-0 · Cited by 210 · see citing works
Patt, A., Harken, A. H., Burton, L. K., Rodell, T. C., Piermattei, D., Schorr, W., Parker, N. B., Berger, E. M., Horesh, I. R., & Terada, L. S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113488 · Cited by 209 · see citing works
Engberding, N., Spiekermann, S., Schaefer, A., Heineke, A., Wiencke, A., Müller, M. F., Fuchs, M., Hilfiker‐Kleiner, D., Hornig, B., Drexler, H., et al. (2004) · Circulation · doi:10.1161/01.cir.0000144303.24894.1c · Cited by 209 · see citing works
Deitch, E. A., Bridges, W. C., Baker, J., W., J., Ma, L., Grisham, M. B., Dn, G., Rd, S., & Berg, R. D. (1988) · PubMed · Cited by 206 · see citing works
Ungvari, Z. I., Gupte, S. A., Recchia, F. A., Bátkai, S., & Pacher, P. (2005) · Current Vascular Pharmacology · doi:10.2174/1570161054368607 · Cited by 205 · see citing works
Self-citationTruglio, J. J., Theis, K. W., Leimkühler, S., Rappa, R., Rajagopalan, K. V., & Kisker, C. (2002) · Structure · doi:10.1016/s0969-2126(01)00697-9 · Cited by 204 · see citing works
Das, D. K., Engelman, R. M., Clement, R., Otani, H., Prasad, M. R., & Rao, P. S. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91112-0 · Cited by 204 · see citing works
Role of reactive oxygen metabolites in experimental colitis.
Keshavarzian, A., Morgan, G., Sedghi, S., Gordon, J. H., & Doria, M. I. (1990) · Gut · doi:10.1136/gut.31.7.786 · Cited by 197 · see citing works
Saavedra, W. F., Paolocci, N., John, M. E. S., Skaf, M. W., Stewart, G. C., Xie, J.-S., Harrison, R. W., Zeichner, J., Mudrick, D. W., Marbán, E., et al. (2002) · Circulation Research · doi:10.1161/hh0302.104531 · Cited by 196 · see citing works
van Bel, F., Shadid, M., Moison, R. M. W., Dorrepaal, C. A., Fontijn, J. R., Monteiro, L. M., van de Bor, M., & Berger, H. M. (1998) · PEDIATRICS · doi:10.1542/peds.101.2.185 · Cited by 195 · see citing works
Xanthine Oxidase-mediated Decomposition of S-Nitrosothiols
Trujillo, M., Álvarez, M. N., Peluffo, G., Freeman, B. Α., & Radí, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.7828 · Cited by 192 · see citing works
Reduction of the size of infarction by allopurinol in the ischemic-reperfused canine heart.
Werns, S. W., Shea, M. J., Mitsos, S. E., Dysko, R. C., Fantone, J. C., Schork, M. A., Abrams, G. D., Pitt, B., & Lucchesi, B. R. (1986) · Circulation · doi:10.1161/01.cir.73.3.518 · Cited by 190 · see citing works
Circulating xanthine oxidase: potential mediator of ischemic injury
Yokoyama, Y., Beckman, J. S., Beckman, T. K., Wheat, J. K., Cash, T., Freeman, B. Α., & Parks, D. A. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.4.g564 · Cited by 188 · see citing works
Role of Xanthine Oxidoreductase as an Antimicrobial Agent
Martin, H. M., Hancock, J. T., Salisbury, V. C., & Harrison, R. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.4933-4939.2004 · Cited by 188 · see citing works
Sawa, T., Akaike, T., & Maeda, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910169199 · Cited by 185 · see citing works
Hypocalcemia and osteopathy in mice with kidney‐specific megalin gene defect
Leheste, J.-R., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner‐Müller, I., Andreassen, T. T., Wolf, E., Bachmann, S., Nykjær, A., et al. (2002) · The FASEB Journal · doi:10.1096/fj.02-0578fje · Cited by 185 · see citing works
Gout: On the brink of novel therapeutic options for an ancient disease
Bieber, J. D., & Terkeltaub, R. A. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20438 · Cited by 181 · see citing works
Reimer, K. A., & Jennings, R. B. (1985) · Circulation · doi:10.1161/01.cir.71.5.1069 · Cited by 180 · see citing works
Nitric oxide and excitation–contraction coupling
Hare, J. M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00143-3 · Cited by 179 · see citing works
Nitric Oxide Regulation of Myocardial Contractility and Calcium Cycling
Khan, S. A., Skaf, M. W., Harrison, R. W., Lee, K. H., Minhas, K. M., Kumar, A., Fradley, M., Shoukas, A. A., Berkowitz, D. E., & Hare, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000078171.52542.9e · Cited by 178 · see citing works
Obrosova, I. G., Pacher, P., Szabó, C., Zsengellér, Z. K., Hirooka, H., Stevens, M. J., & Yorek, M. A. (2005) · Diabetes · doi:10.2337/diabetes.54.1.234 · Cited by 178 · see citing works
Self-citationChemical Suppression of the Immune Response
Hitchings, G. H., & Elion, G. B. (1962) · Blood · doi:10.1182/blood.v20.1.111.111 · Cited by 177 · see citing works
Szabó, C., Mabley, J. G., Moeller, S. M., Shimanovich, R., Pacher, P., Virág, L., Soriano, F. G., van Duzer, J. H., Williams, W., Salzman, A. L., et al. (2002) · Molecular Medicine · doi:10.1007/bf03402167 · Cited by 175 · see citing works
Self-citationAllopurinol Administered after Inducing Hypoxia-Ischemia Reduces Brain Injury in 7-Day-Old Rats
Palmer, C., Towfighi, J., Roberts, R. L., & Heitjan, D. F. (1993) · Pediatric Research · doi:10.1203/00006450-199304000-00018 · Cited by 174 · see citing works
Szabó, C., Zanchi, A., Komjáti, K., Pacher, P., Królewski, A. S., Quist, W. C., LoGerfo, F. W., Horton, E. S., & Veves, A. (2002) · Circulation · doi:10.1161/01.cir.0000038365.78031.9c · Cited by 171 · see citing works
Self-citationXanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy
Minhas, K. M., Saraiva, R. M., Schuleri, K. H., Lehrke, S., Zheng, M., SALIARIS, A. P., Berry, C. E., Vandegaer, K., Li, D., & Hare, J. M. (2005) · Circulation Research · doi:10.1161/01.res.0000200181.59551.71 · Cited by 170 · see citing works
Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system
Pritsos, C. A. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00203-9 · Cited by 167 · see citing works
Mechanism of the Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
Nishino, T., Okamoto, K., Kawaguchi, Y., Hori, H., Matsumura, T., Eger, B. T., PAI, E. F., & Nishino, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501830200 · Cited by 167 · see citing works
Martz, D., Rayos, G. H., Schielke, G. P., & Betz, A. L. (1989) · Stroke · doi:10.1161/01.str.20.4.488 · Cited by 166 · see citing works
Lynch, E. D., Gu, R., Pierce, C., & Kil, J. (2004) · Hearing Research · doi:10.1016/j.heares.2004.08.002 · Cited by 164 · see citing works
Xanthine oxidase: a critical mediator of myocardial injury during ischemia and reperfusion?
Hearse, D. J., MANNING, A. S., Downey, J. M., & Yellon, D. M. (1986) · PubMed · Cited by 162 · see citing works
Role of Xanthine Oxidase and Its Inhibitor in Hypoxia: Reoxygenation Injury
Saugstad, O. D. (1996) · PEDIATRICS · doi:10.1542/peds.98.1.103 · Cited by 155 · see citing works
Mayer, M. D., Khosravan, R., Vernillet, L., Wu, J., Joseph‐Ridge, N., & Mulford, D. J. (2005) · American Journal of Therapeutics · doi:10.1097/00045391-200501000-00005 · Cited by 155 · see citing works
Umezawa, K., Akaike, T., Fujii, S., Suga, M., Setoguchi, K., Ozawa, A., & Maeda, H. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2932-2940.1997 · Cited by 154 · see citing works
McKelvey, T. G., Höllwarth, M. E., Granger, D. N., Engerson, T. D., Landler, U., & Jones, H. P. (1988) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1988.254.5.g753 · Cited by 151 · see citing works
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats
Khadour, F., Panas, D. L., Ferdinandy, P., Schulze, C. J., Csont, T., Lalu, M. M., Wildhirt, S. M., & Schulz, R. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00549.2001 · Cited by 150 · see citing works
Struthers, A. D., Donnan, P. T., Lindsay, P., McNaughton, D., Broomhall, J., & MacDonald, T. M. (2002) · Heart · doi:10.1136/heart.87.3.229 · Cited by 146 · see citing works
Patetsios, P., Song, M., Shutze, W. P., Pappas, C., Rodino, W., Ramirez, J. A., & Panetta, T. F. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01621-6 · Cited by 143 · see citing works
Uric acid and cardiovascular risk
Alderman, M. H. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00143-1 · Cited by 140 · see citing works
Effect of allopurinol on hemorrhagic shock
Crowell, J. W., Ce, J., & Ee, S. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.4.744 · Cited by 140 · see citing works
A randomized controlled trial of allopurinol in coronary bypass surgery
Johnson, W. D., Kayser, K. L., Brenowitz, J. B., & Saedi, S. F. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90950-m · Cited by 139 · see citing works
Myers, C. L., Weiss, S. J., Kirsh, M. M., Shepard, B. M., & Shlafer, M. (1986) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)36093-3 · Cited by 139 · see citing works
Brown, J. M., Terada, L. S., Grosso, M. A., Whitmann, G. J., Velasco, S. E., Patt, A., Harken, A. H., & Repine, J. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113448 · Cited by 137 · see citing works
Phosphorylation of Xanthine Dehydrogenase/Oxidase in Hypoxia
Kayyali, U. S., Donaldson, C., Huang, H., Abdelnour, R., & Hassoun, P. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010100200 · Cited by 136 · see citing works
Vascular Release of Superoxide Radicals Is Enhanced in Hypercholesterolemic Rabbits
Mügge, A., Brandes, R. P., Böger, R. H., Dwenger, A., Bode‐Böger, S. M., Kienke, S., Frölich, J. C., & Lichtlen, P. R. (1994) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199424060-00019 · Cited by 135 · see citing works
Xanthine oxidase activity in the circulation of rats following hemorrhagic shock
Tan, S., Yokoyama, Y., Dickens, E., Cash, T., Freeman, B. Α., & Parks, D. A. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90040-2 · Cited by 134 · see citing works
Rott, K. T., & Agudelo, C. A. (2003) · JAMA · doi:10.1001/jama.289.21.2857 · Cited by 131 · see citing works
Terada, L. S., Dormish, J. J., Shanley, P. F., Leff, J. A., Anderson, B. O., & Repine, J. E. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.3.l394 · Cited by 130 · see citing works
Synthesis and structure–activity relationships of 1-Phenylpyrazoles as xanthine oxidase inhibitors
Ishibuchi, S., Morimoto, H., Oe, T., Ikebe, T., Inoue, H., Fukunari, A., Kamezawa, M., YAMADA, I., & Naka, Y. (2001) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00093-2 · Cited by 128 · see citing works
Gout: epidemiology and lifestyle choices.
Choi, H. K., & Curhan, G. C. (2005) · PubMed · Cited by 126 · see citing works
Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart
Downey, J. M., Miura, T., Eddy, L. J., Chambers, D. E., Mellert, T. K., Hearse, D. J., & Yellon, D. M. (1987) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(87)80350-4 · Cited by 126 · see citing works
Cellular expression of xanthine oxidoreductase protein in normal human tissues.
Linder, N., Rapola, J., & Raivio, K. O. (1999) · PubMed · Cited by 125 · see citing works
Mervaala, E. M. A., Cheng, Z. J., Tikkanen, I. T., Lapatto, R., Nurminen, K., Vapaatalo, H., Müller, D. N., Fiebeler, A., Ganten, U., Ganten, D., et al. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.414 · Cited by 122 · see citing works
THE ROLE OF O2‐ IN THE CHEMILUMINESCENCE OF LUMINOL*
Hodgson, E. K., & Fridovich, I. (1973) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1973.tb06449.x · Cited by 120 · see citing works
Enhanced Expression and Activity of Xanthine Oxidoreductase in the Failing Heart
de Jong, J. W., Schoemaker, R. G., de Jonge, R., Bernocchi, P., Keijzer, E., Harrison, R., Sharma, H. S., & Ceconi, C. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1240 · Cited by 120 · see citing works
Radí, R., Rubbo, H., Bush, K., & Freeman, B. Α. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.9844 · Cited by 120 · see citing works
Prevention of free radical-induced myocardial reperfusion injury with allopurinol
Stewart, J. R., Crute, S. L., Loughlin, V., Hess, M. L., & Greenfield, L. J. (1985) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38664-7 · Cited by 119 · see citing works
Ukai, T., Cheng, C., Tachibana, H., Igawa, A., Zhang, Z.-S., Cheng, H.-J., & Little, W. C. (2001) · Circulation · doi:10.1161/01.cir.103.5.750 · Cited by 115 · see citing works
Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium
McNally, J. S., Saxena, A., Cai, H. “., Dikalov, S., & Harrison, D. G. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000170827.16296.6e · Cited by 115 · see citing works
Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein.
Sarnesto, A., Linder, N., & Raivio, K. O. (1996) · PubMed · Cited by 114 · see citing works
Nakashima, M., Niwa, M., Iwai, T., & Uematsu, T. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00257-3 · Cited by 114 · see citing works
Fukunari, A., Okamoto, K., Nishino, T., Eger, B. T., PAI, E. F., Kamezawa, M., YAMADA, I., & Katô, N. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.070433 · Cited by 114 · see citing works
Nishizawa, J., Nakai, A., Matsuda, K., Komeda, M., Ban, T., & Nagata, K. (1999) · Circulation · doi:10.1161/01.cir.99.7.934 · Cited by 112 · see citing works
Confirmation of Superoxide Generation via Xanthine Oxidase in Streptozotocin-induced Diabetic Mice
Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., & Utsumi, H. (2003) · Free Radical Research · doi:10.1080/1071576031000107344 · Cited by 112 · see citing works
Zhang, Z., Blake, D. R., Stevens, C. R., Kanuler, J. M., Ward, P. G., Symons, M. C. R., Benboubetra, M., & Harrison, R. (1998) · Free Radical Research · doi:10.3109/10715769809065801 · Cited by 110 · see citing works
Stull, L. B., Leppo, M. K., Szweda, L. I., Gao, W. D., & Marbán, E. (2004) · Circulation Research · doi:10.1161/01.res.0000148635.73331.c5 · Cited by 110 · see citing works
Role of xanthine oxidase in ischemia/reperfusion injury
Linas, S. L., Whittenburg, D., & Repine, J. E. (1990) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1990.258.3.f711 · Cited by 109 · see citing works
Role of oxygen free radicals in shock, ischemia, and organ preservation
Bingham, H. G. (1984) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-198408000-00086 · Cited by 109 · see citing works
Hassoun, P. M., Yu, F., Côté, C., Zulueta, J. J., Sawhney, R., Skinner, K. A., Skinner, H. B., Parks, D. A., & Lanzillo, J. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9709116 · Cited by 108 · see citing works
Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine
Nilsson, U. A., Schoenberg, M. H., Åneman, A., Poch, B., Magadum, S., Beger, H. G., & Lundgren, O. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90695-5 · Cited by 107 · see citing works
Allopurinol: Intravenous Use for Prevention and Treatment of Hyperuricemia
Smalley, R. V., Guaspari, A., Haase-Statz, S., Anderson, S. A., Cederberg, D., & Hohneker, J. A. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1758 · Cited by 107 · see citing works
Kuwabara, Y., Nishino, T., Okamoto, K., Matsumura, T., Eger, B. T., PAI, E. F., & Nishino, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431485100 · Cited by 107 · see citing works
Contribution of oxygen-derived free radicals to experimental necrotizing enterocolitis.
Clark, D. A., Fornabaio, D. M., McNeill, H., Mullane, K., Caravella, S. J., & Miller, M. J. (1988) · PubMed Central · Cited by 107 · see citing works
Gavin, A. D., & Struthers, A. D. (2005) · Heart · doi:10.1136/hrt.2004.040477 · Cited by 106 · see citing works
Itoh, T., Kawakami, M., Yamauchi, Y., Shimizu, S., & Nakamura, M. (1986) · Stroke · doi:10.1161/01.str.17.6.1284 · Cited by 106 · see citing works
Sedghi, S., Fields, J. Z., Klamut, M., Urban, G., Durkin, M., Winship, D. H., Fretland, D. J., Olyaee, M. S., & Keshavarzian, A. (1993) · Gut · doi:10.1136/gut.34.9.1191 · Cited by 104 · see citing works
Drug-Induced Severe Skin Reactions
Wolkenstein, P., & Revuz, J. E. (1995) · Drug Safety · doi:10.2165/00002018-199513010-00007 · Cited by 104 · see citing works
Shatney, C. H., MacCarter, D., & Lillehei, R. C. (1976) · The American Journal of Cardiology · doi:10.1016/0002-9149(76)90398-2 · Cited by 104 · see citing works
Budzyńska, A., Marek, T., Nowak, A. J., Kaczor, R., & Nowakowska-Duława, E. (2001) · Endoscopy · doi:10.1055/s-2001-16520 · Cited by 102 · see citing works
A Mechanism of Oxygen Free Radical Production in the Dahl Hypertensive Rat
SWEI, A., Lacy, F., DeLano, F. A., Parks, D. A., & Schmid‐Schönbein, G. W. (1999) · Microcirculation · doi:10.1111/j.1549-8719.1999.tb00100.x · Cited by 100 · see citing works
The Reductive Half-reaction of Xanthine Oxidase
Xia, M., Dempski, R. E., & Hille, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3323 · Cited by 99 · see citing works
Page, S., POWELL, D., Benboubetra, M., Stevens, C. R., Blake, D. R., Selase, F., Wolstenholme, A. J., & Harrison, R. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00028-2 · Cited by 98 · see citing works
Akizuki, S., Yoshida, S., Chambers, D. E., Eddy, L. J., Parmley, L. F., Yellon, D. M., & Downey, J. M. (1985) · Cardiovascular Research · doi:10.1093/cvr/19.11.686 · Cited by 98 · see citing works
Cicoira, M., Zanolla, L., Rossi, A., Golia, G., Franceschini, L., Brighetti, G., Zeni, P., & Zardini, P. (2002) · American Heart Journal · doi:10.1067/mhj.2002.122122 · Cited by 97 · see citing works
MECHANISMS OF ENDOTOXIN-INDUCED INTESTINAL INJURY IN A HYPERDYNAMIC MODEL OF SEPSIS
Xu, D.-Z., Lu, Q., Guillory, D., Cruz, N., Berg, R. D., & Deitch, E. A. (1993) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199305000-00010 · Cited by 97 · see citing works
Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase
Metzger, J., Dore, S. P., & Lauterburg, B. H. (1988) · Hepatology · doi:10.1002/hep.1840080324 · Cited by 97 · see citing works
Pacher, P., Liaudet, L., Mabley, J. G., Komjáti, K., & Szabó, C. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02062-4 · Cited by 97 · see citing works
Self-citationEvidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium
Charlat, M. I., O’Neill, P. G., Egan, J., Abernethy, D. R., Michael, L. H., Myers, M. L., Roberts, R., & Bolli, R. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.252.3.h566 · Cited by 96 · see citing works
Becker, M. A., Kisicki, J. C., Khosravan, R., Wu, J., Mulford, D. J., Hunt, B., MacDonald, P., & Joseph‐Ridge, N. (2004) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1081/ncn-200027372 · Cited by 96 · see citing works
Recent advances in the management of gout and hyperuricemia
Wortmann, R. L. (2005) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000162060.25895.a5 · Cited by 95 · see citing works
Novel Myofilament Ca 2+ -Sensitizing Property of Xanthine Oxidase Inhibitors
Pérez, N. G., Gao, W. D., & Marbán, E. (1998) · Circulation Research · doi:10.1161/01.res.83.4.423 · Cited by 95 · see citing works
Coghlan, G., Flitter, W. D., Clutton, S. M., Panda, R., Daly, R., Wright, G., Ilsley, C. D. J., & Slater, T. F. (1994) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(94)70478-3 · Cited by 94 · see citing works
Effects of Antioxidants and Free Radical Scavengers in Three Different Models of Acute Pancreatitis
Niederau, C., Niederau, M., Borchard, F., Ude, K., Luthen, R. E., Strohmeyer, G. W., Ferrell, L. D., & Grendell, J. H. (1992) · Pancreas · doi:10.1097/00006676-199207000-00011 · Cited by 92 · see citing works
Guan, W., Osanai, T., Kamada, T., Hanada, H., Ishizaka, H., Onodera, H., Iwasa, A., Fujita, N., Kudo, S., Ohkubo, T., et al. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200305000-00005 · Cited by 91 · see citing works
Kinugawa, S., Huang, H., Wang, Z., Kaminski, P. M., Wolin, M. S., & Hintze, T. H. (2005) · Circulation Research · doi:10.1161/01.res.0000155331.09458.a7 · Cited by 90 · see citing works
Mellin, V., Isabelle, M., Oudot, A., Vergely, C., Monteil, C., Meglio, B. D., Henry, J., Dautréaux, B., Rochette, L., Thuillez, C., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi305 · Cited by 90 · see citing works
Inhibition of Xanthine Oxidase and Xanthine Dehydrogenase by Nitric Oxide
Ichimori, K., Fukahori, M., Nakazawa, H. K., Okamoto, K., & Nishino, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7763 · Cited by 89 · see citing works
McKechnie, K. C. W., Bl, F., & Parratt, J. R. (1986) · PubMed · Cited by 88 · see citing works
Miesel, R., & Zuber, M. A. (1993) · Inflammation · doi:10.1007/bf00914193 · Cited by 87 · see citing works
Beetsch, J. W., Park, T. S., Dugan, L. L., Shah, A. R., & Gidday, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01407-8 · Cited by 86 · see citing works
Endothelial dysfunction in aging animals: the role of poly(ADP‐ribose) polymerase activation
Pacher, P., Mabley, J. G., Soriano, F. G., Liaudet, L., Komjáti, K., & Szabó, C. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704627 · Cited by 86 · see citing works
Self-citationInfluence of antihyperuricemic therapy on the clinical and radiographic progression of gout
McCarthy, G., Barthelemy, C. R., Veum, J. A., & Wortmann, R. L. (1991) · Arthritis & Rheumatism · doi:10.1002/art.1780341203 · Cited by 84 · see citing works
Improvement of Cardiac Function by Allopurinol in Patients Undergoing Cardiac Surgery
Castelli, P., Condemi, A. M., Brambillasca, C., Fundaro, P. M., Botta, M., Lemma, M. G., Vanelli, P., Santoli, C., Gatti, S., & Riva, E. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199501000-00019 · Cited by 84 · see citing works
Allopurinol Prevents Early Alcohol-Induced Liver Injury in Rats
Kono, H., Rusyn, I., Bradford, B. U., Connor, H. D., Mason, R. P., & Thurman, R. G. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39232-8 · Cited by 84 · see citing works
Physiologic Levels of Uric Acid Inhibit Xanthine Oxidase in Human Plasma
Tan, S., Radí, R., Gaudier, F. L., Evans, R. A., Rivera, A., Kirk, K. A., & Parks, D. A. (1993) · Pediatric Research · doi:10.1203/00006450-199309000-00013 · Cited by 83 · see citing works
Salim, A. S. (1992) · PubMed · Cited by 82 · see citing works
Badylak, S. F., Simmons, A. W., Turek, J. J., & Babbs, C. F. (1987) · Cardiovascular Research · doi:10.1093/cvr/21.7.500 · Cited by 78 · see citing works
Rouquette, M., Page, S., Bryant, R., Benboubetra, M., Stevens, C. R., Blake, D. R., Whish, W. D., Harrison, R., & Tosh, D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00385-8 · Cited by 78 · see citing works
Angiotensin II-Mediated Endothelial Dysfunction: Role of Poly(ADP-ribose) Polymerase Activation
Szabó, C., Pacher, P., Zsengellér, Z. K., Vaslin, A., Komjáti, K., Benkő, R., Chen, M., Mabley, J. G., & Kollai, M. (2004) · Molecular Medicine · doi:10.2119/2004-00001.szabo · Cited by 77 · see citing works
Self-citationSimultaneous Liver and Lung Injury Following Gut Ischemia is Mediated by Xanthine Oxidase
Poggetti, R. S., Moore, F. A., Moore, E. E., KOEIKE, K., & Banerjee, A. M. (1992) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199206000-00008 · Cited by 77 · see citing works
Superoxide radical involvement in the pathogenesis of burn shock.
Sáez, J. C., Ward, P. H., Günther, B., & Vivaldi, E. (1984) · PubMed · Cited by 77 · see citing works
Potentiation of Nitric Oxide--Mediated Vasorelaxation by Xanthine Oxidase Inhibitors
Miyamoto, Y., Akaike, T., Yoshida, M., Goto, S., Horie, H., & Maeda, H. (1996) · Experimental Biology and Medicine · doi:10.3181/00379727-211-43982 · Cited by 76 · see citing works
Circulating Xanthine Oxidase in Human Ischemia Reperfusion
Tan, S., Gelman, S., Wheat, J. K., & Parks, D. A. (1995) · Southern Medical Journal · doi:10.1097/00007611-199504000-00021 · Cited by 76 · see citing works
Nitric Oxide Reversibly Suppresses Xanthine Oxidase Activity
Fukahori, M., Ichimori, K., Ishida, H., Nakagawa, H., & Okino, H. (1994) · Free Radical Research · doi:10.3109/10715769409056572 · Cited by 75 · see citing works
Vasculitis with allopurinol therapy
Jarzobski, J. A., Ferry, J., Wombolt, D. G., Fitch, D. M., & Egan, J. D. (1970) · American Heart Journal · doi:10.1016/0002-8703(70)90401-1 · Cited by 75 · see citing works
Maurer, H., Steinherz, P. G., Gaynon, P. S., Finklestein, J. Z., Sather, H. N., Reaman, G. H., Bleyer, W. A., & Hammond, G. D. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.9.1425 · Cited by 74 · see citing works
Flagged first, then by citations
5 of the 451 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Giler S, Eshel Y, Pinkhas J, Ventura E, Levy E, Urea I, Sperling O, de Vries A. Elevation of serum xanthine oxidase activity following halothane anesthesia in man. Experientia. 1977;33:1356–1358. doi: 10.1007/BF01920178. [DOI] [PubMed] [Google Scholar] · DOI
- Kuzmin AI, Tskitishvili OV, Serebryakova LI, Kapelko VI, Majorova IV, Medvedev OS. Allopurinol: kinetics, inhibition of xanthine oxidase activity and protective effect in ischemic-reperfused canine heart as studied by cardiac microdialysis. J Cardiovasc Pharmacol. 1995;25:564–571. [PubMed] [Google Scholar]
- Mabley JG, Nivorozhkin A, Southan GJ, Szabó C, Salzman AL. Pathogenetic role of xanthine oxidase in a murine model of acute lung injury. FASEB J. 2003;17:A247. [Google Scholar]
- Nivorozhkin A, Mabley J, Pacher P, Southan GJ, Szabó C, Salzman AL. A novel xanthine oxidase inhibitor, AN-01-24, protects against development of colitis in mice. FASEB J. 2003a;17:A265. [Google Scholar]
- Nivorozhkin A, Mabley JG, Pacher P, Li H, Southan GJ, Szabó C, Salzman AL. A novel class of potent non-purine based xanthine oxidase inhibitors: antihyperuricemic and hepatoprotective effects. FASEB J. 2003b;17:A253. [Google Scholar]
Cited by
Sorted by citations
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works
Self-citationReactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897 · see citing works
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907 · see citing works
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
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Heravi, M. M., & Zadsirjan, V. (2020) · RSC Advances · doi:10.1039/d0ra09198g · Cited by 1,226 · see citing works
Reactive oxygen species: from health to disease
Brieger, K., Schiavone, S., Miller Jr., F. J., & Krause, K.-H. (2012) · Swiss Medical Weekly · doi:10.4414/smw.2012.13659 · Cited by 1,133 · see citing works
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Jomova, K., Makova, M., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., Rhodes, C. J., & Valko, M. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110173 · Cited by 1,121 · see citing works
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Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugawara, M., & Iseki, K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.09.035 · Cited by 967 · see citing works
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BackgroundInfluentialGonzalez, L. M., Moeser, A. J., & Blikslager, A. T. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00112.2013 · Cited by 251 · see citing works
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Self-citationSelemidis, S., Sobey, C. G., Wingler, K., Schmidt, H. H. H. W., & Drummond, G. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.08.005 · Cited by 241 · see citing works
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Vaughan, V. C., Martin, P., & Lewandowski, P. A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0087-1 · Cited by 233 · see citing works
Puddu, P., Puddu, G. M., Cravero, E., Vizioli, L., & Muscari, A. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.01.013 · Cited by 236 · see citing works
Lehner, C., Gehwolf, R., Tempfer, H., Krizbai, I. A., Hennig, B., Bauer, H., & Bauer, H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3923 · Cited by 231 · see citing works
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Lin, S., Zhang, G., Liao, Y., Pan, J., & Gong, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b03386 · Cited by 215 · see citing works
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Rajesh, M., Mukhopadhyay, P., Haskó, G., Huffman, J. W., Mackie, K., & Pacher, P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707569 · Cited by 197 · see citing works
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Yan, J., Zhang, G., Hu, Y., & Ma, Y. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.06.092 · Cited by 195 · see citing works
Ioachimescu, A. G., Brennan, D. M., Hoar, B. M., Hazen, S. L., & Hoogwerf, B. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23121 · Cited by 194 · see citing works
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Cheung, K. J., Tzameli, I., Pissios, P., Rovira, I. I., Gavrilova, O., Ohtsubo, T., Chen, Z., Finkel, T., Flier, J. S., & Friedman, J. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.005 · Cited by 187 · see citing works
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Zhao, J., Huang, L., Sun, C., Zhao, D., & Tang, H. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126807 · Cited by 159 · see citing works
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Zhang, Y., Du, Y., Le, W., Wang, K., Kieffer, N., & Zhang, J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3685 · Cited by 156 · see citing works
Role of inflammasomes in the pathogenesis of periodontal disease and therapeutics
Marchesan, J. T., Girnary, M., MOSS, K. L., Monaghan, E., Egnatz, G. J., Jiao, Y., Zhang, S., Beck, J., & Swanson, K. V. (2019) · Periodontology 2000 · doi:10.1111/prd.12269 · Cited by 159 · see citing works
Ullrich (2018) · doi:10.1038/mp.2017.188 · Cited by 145 · see citing works
Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity
Liaudet, L., Calderari, B., & Pacher, P. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9418-y · Cited by 150 · see citing works
Self-citationSuccinate metabolism: a new therapeutic target for myocardial reperfusion injury
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw100 · Cited by 149 · see citing works
Gout and Metabolic Syndrome: a Tangled Web
Thottam, G. E., Krasnokutsky, S., & Pillinger, M. H. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0688-y · Cited by 152 · see citing works
Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP
Johnson, T. A., Jinnah, H. A., & Kamatani, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00098 · Cited by 148 · see citing works
Osman, N. I., Sidik, N. J., Awal, A., Adam, N. I., & Rezali, N. I. (2016) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20160731025522 · Cited by 150 · see citing works
Rajesh, M., Pan, H., Mukhopadhyay, P., Bátkai, S., Osei‐Hyiaman, D., Haskó, G., Liaudet, L., Gao, B., & Pacher, P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307180 · Cited by 150 · see citing works
Self-citationGout, Allopurinol Use, and Heart Failure Outcomes
Thanassoulis, G. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.198 · Cited by 147 · see citing works
Reactive oxygen and nitrogen species in normal physiological processes
Pourová, J., Kottová, M., Vopršalová, M., & Pour, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02039.x · Cited by 146 · see citing works
Control of Reactive Oxygen Species Production in Contracting Skeletal Muscle
Jackson, M. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3976 · Cited by 145 · see citing works
Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy
Jourdan, T., Szanda, G., Rosenberg, A. Z., Tam, J., Earley, B. J., Godlewski, G., Çınar, R., Liu, Z., Liu, J., Ju, C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419901111 · Cited by 142 · see citing works
Self-citationLeishmaniasis: Prevention, Parasite Detection and Treatment
Kobets, T., Grekov, I., & Lipoldová, M. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799828300 · Cited by 142 · see citing works
Batinic̈‐Haberle, I., Cuzzocrea, S., Reboucas, J. S., Ferrer‐Sueta, G., Mazzon, E., Paola, R. D., Radí, R., Spasojević, I., Benov, L., & Salvemini, D. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.042 · Cited by 140 · see citing works
Chuang, S., Lee, S.-C., Hsieh, Y.-T., & Pan, W. (2011) · PubMed · Cited by 140 · see citing works
Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila
van Dam, E., van Leeuwen, L. A. G., dos Santos, E., James, J., Best, L., Lennicke, C., Vincent, A. J., Μαρίνος, Γ., Foley, A., Buricova, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.016 · Cited by 140 · see citing works
- Authors
- Pacher, P., Nivorozhkin, A., & Szabó, C.
- Affiliations
- National Institutes of Health (US)
- Semmelweis University (HU)
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 58
- Issue
- 1
- Pages
- 87-114
- ISSN
- 0031-6997 (ISSN-L)
- PMC
- PMC2233605
- OpenAlex
- W2119515450
- Cited by
- 1,218
- References
- 451
- Citations by year
- 2026: 34 · 2025: 51 · 2024: 60 · 2023: 56 · 2022: 83 · 2021: 75 · 2020: 85 · 2019: 84 · 2018: 72 · 2017: 71 · 2016: 67 · 2015: 76 · 2014: 75 · 2013: 67 · 2012: 72
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000375)
- Topics
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- xanthine oxidase inhibitors, allopurinol, oxypurinol, gout, hyperuricemia, ischemic injury, vascular injury, inflammation, chronic heart failure, drug repurposing
- MeSH terms
- Allopurinol, Animals, Cardiovascular Diseases, Enzyme Inhibitors, Humans, Superoxides, Xanthine Oxidase, Inflammatory Bowel Diseases, Reperfusion Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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