Cited by 1,607Hemoglobinopathies and Related DisordersGenomics and Chromatin DynamicsGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Open access

Moi, P, Chan, K, Asunis, I, Cao, A, Kan, Y W·1994·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.91.21.9926PMC PMC44930

Open this paper in CoChat — free account

Abstract

Hypersensitive site 2 located in the beta-globin locus control region confers high levels of expression to the genes of the beta-globin cluster. A tandem repeat of the consensus sequence for the transcription factors AP1 and NF-E2 (activating protein 1 and nuclear factor erythroid 2, respectively) is present within hypersensitive site 2 and is absolutely required for strong enhancer activity. This sequence binds, in vitro and in vivo, to ubiquitous proteins of the AP1 family and to the recently cloned erythroid-specific transcription factor NF-E2. Using the tandem repeat as a recognition site probe to screen a lambda gt11 cDNA expression library from K562 cells, we isolated several DNA binding proteins. Here, we report the characterization of one of the clones isolated. The gene, which we named Nrf2 (NF-E2-related factor 2), is encoded within a 2.2-kb transcript and predicts a 66-kDa protein with a basic leucine zipper DNA binding domain highly homologous to that of NF-E2. Although Nrf2 is expressed ubiquitously, a role of this protein in mediating enhancer activity of hypersensitive site 2 in erythroid cells cannot be excluded. In this respect, Nrf2 contains a powerful acidic activation domain that may participate in the transcriptional stimulation of beta-globin genes.

Integrity signals

Registry

Crossref · 10.1073/pnas.91.21.9926

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,090
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Firefly Luciferase Gene: Structure and Expression in Mammalian Cells
de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046
Position-independent, high-level expression of the human β-globin gene in transgenic mice
Grosveld, F. G., van Assendelft, G. B., Greaves, D. R., & Kollias, G. A. (1987) · Cell · doi:10.1016/0092-8674(87)90584-8 · Cited by 1,908
GAL4-VP16 is an unusually potent transcriptional activator
Sadowski, I., Ma, J., Triezenberg, S., & Ptashne, M. (1988) · Nature · doi:10.1038/335563a0 · Cited by 1,298
Firefly Luciferase Gene: Structure and Expression in Mammalian Cells
de Wet, J. R., Wood, K. V., DeLuca, M. A., et al. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725-737.1987 · Cited by 913
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
Tsai, S., Martin, D. I. K., Zon, L. I., D’Andrea, A. D., Wong, G. G., & Orkin, S. H. (1989) · Nature · doi:10.1038/339446a0 · Cited by 884

Flagged first, then by citations

Show all 41 references

Sorted by citations

Items 301–400 of 1,002

Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary Cells
Gong, P., Hu, B., Stewart, D., Ellerbe, M., Figueroa, Y. G., Blank, V., Beckman, B. S., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103658200 · Cited by 140
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells
Ribeiro, M., Rosenstock, T. R., Oliveira, A. M., Oliveira, C. R., & Rego, A. C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.023 · Cited by 145
Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer
Telkoparan‐Akillilar, P., Panieri, E., Cevik, D., Süzen, S., & Saso, L. (2021) · Molecules · doi:10.3390/molecules26051417 · Cited by 148
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2
Sekhar, K. R., Yan, X. X., & Freeman, M. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205905 · Cited by 139
Nrf1 Is Critical for Redox Balance and Survival of Liver Cells during Development
Chen, L., Kwong, M., Lu, R., Ginzinger, D. G., Lee, C., Leung, L., & Chan, J. Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4673-4686.2003 · Cited by 139
A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics
Su, Z., Shu, L., Khor, T. O., Lee, J. H., Fuentes, F., & Kong, A. T. (2012) · Topics in current chemistry · doi:10.1007/128_2012_340 · Cited by 139
Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage
Anuranjani, & Bala, M. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.008 · Cited by 138
Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin
Hou, K., Shen, J., Yan, J., Zhai, C., Zhang, J., Pan, J.-A., Zhang, Y., Jiang, Y., Wang, Y., Lin, R. Z., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103456 · Cited by 139
Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice
Leiser, S. F., & Miller, R. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01145-09 · Cited by 138
Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif
Li, W., Yu, S., Liu, T., Kim, J. H., Blank, V., Li, H., & Kong, A.-N. T. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.05.024 · Cited by 141
Monocyte differentiation and macrophage polarization
Orekhov, A. N., Orekhova, V. A., Nikiforov, N. G., Myasoedova, V. A., Grechko, A. V., Romanenko, E. B., Zhang, D., & Chistiakov, D. A. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.04 · Cited by 144
Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-Δ 12,14 -Prostaglandin J 2 Is Mediated by the Stress Response Elements and Transcription Factor Nrf2
Gong, P., Stewart, D., Hu, B., Li, N., Cook, J. L., Nel, A. E., & Alam, J. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666307 · Cited by 139
Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
Lee, S., & Hu, L. (2020) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02539-y · Cited by 140
Antioxidant-induced Phosphorylation of Tyrosine 486 Leads to Rapid Nuclear Export of Bach1 That Allows Nrf2 to Bind to the Antioxidant Response Element and Activate Defensive Gene Expression
Kaspar, J. W., & Jaiswal, A. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040022 · Cited by 136
MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
Kabaria, S., Choi, D. C., Chaudhuri, A., Jain, M. R., Li, H., & Junn, E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.09.010 · Cited by 135
Cardiovascular targets for estrogens and phytoestrogens: Transcriptional regulation of nitric oxide synthase and antioxidant defense genes
Siow, R. C. M., Li, F. Y. L., Rowlands, D. J., de Winter, P., & Mann, G. E. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.004 · Cited by 135
Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2
Zhao, X., Sun, G., Zhang, J., Ting, S., Gonzales, N. R., & Aronowski, J. A. (2015) · Stroke · doi:10.1161/strokeaha.115.009398 · Cited by 135
Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease
Villavicencio-Tejo, F., & Quintanilla, R. A. (2021) · Antioxidants · doi:10.3390/antiox10071069 · Cited by 143
α-Melanocyte-Stimulating Hormone Counteracts the Suppressive Effect of UVB on Nrf2 and Nrf-Dependent Gene Expression in Human Skin
Kokot, A., Metze, D., Mouchet, N., Galibert, M.-D., Schiller, M., Luger, T. A., & Böhm, M. (2009) · Endocrinology · doi:10.1210/en.2008-1315 · Cited by 132
The mutational landscape of hepatocellular carcinoma
Lee, J. (2015) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2015.21.3.220 · Cited by 134
Chemoprotection by Organosulfur Inducers of Phase 2 Enzymes: Dithiolethiones and Dithiins
Kensler, T. W., Curphey, T. J., Maxiutenko, Y., & Roebuck, B. D. (2000) · Drug metabolism and drug interactions · doi:10.1515/dmdi.2000.17.1-4.3 · Cited by 131
Nrf2 activation as target to implement therapeutic treatments
Bocci, V. A., & Valacchi, G. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00004 · Cited by 131
1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis
Yang, R., Chen, J., Zhang, J., Qin, R., Wang, R., Qiu, Y., Mao, Z., Goltzman, D., & Miao, D. (2019) · Aging Cell · doi:10.1111/acel.13095 · Cited by 132
Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders
Njomen, E., & Tepe, J. J. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00101 · Cited by 133
NRF2, cancer and calorie restriction
Martín‐Montalvo, A., Villalba, J. M., Navas, P., & de Cabo, R. (2010) · Oncogene · doi:10.1038/onc.2010.492 · Cited by 129
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury
Jadeja, R. N., Upadhyay, K. K., Devkar, R., & Khurana, S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3453926 · Cited by 127
Accelerated Ovarian Failure Induced by 4-Vinyl Cyclohexene Diepoxide in Nrf2 Null Mice
Hu, X., Roberts, J. R., Apopa, P. L., Kan, Y. W., & Ma, Q. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.940-954.2006 · Cited by 127
Self-citation
Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
Namani, A., Li, Y., Wang, X. J., & Tang, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.003 · Cited by 128
Human Cell Toxicogenomic Analysis Linking Reactive Oxygen Species to the Toxicity of Monohaloacetic Acid Drinking Water Disinfection Byproducts
Pals, J. A., Attene‐Ramos, M. S., Xia, M., Wagner, E. D., & Plewa, M. J. (2013) · Environmental Science & Technology · doi:10.1021/es403171b · Cited by 129
Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions
Denis, M.-C., Desjardins, Y., Fürtös, A., Marcil, V., Dudonné, S., Montoudis, A., Garofalo, C., DELVIN, E. E., Marette, A., & Levy, E. H. (2014) · Clinical Science · doi:10.1042/cs20140210 · Cited by 126
Long noncoding RNAs: regulation, function and cancer
Rafiee, A., Riazi‐Rad, F., Havaskary, M., & Nuri, F. (2018) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2018.1471566 · Cited by 127
hMAF, a Small Human Transcription Factor That Heterodimerizes Specifically with Nrf1 and Nrf2
Marini, M. G., Chan, K., Casula, L., Kan, Y. W., Cao, A., & Moi, P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16490 · Cited by 126
Self-citation
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
Zhang, Y., & Xiang, Y. (2016) · Biochemical Journal · doi:10.1042/bj20151182 · Cited by 125
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
Lu, Y., Sun, Y., Liu, Z., Lu, Y., Zhu, X., Lan, B., Mi, Z., Dang, L., Li, N., Zhan, W., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aba3613 · Cited by 125
Nrf2-Dependent Activation of the Antioxidant Responsive Element by tert-Butylhydroquinone Is Independent of Oxidative Stress in IMR-32 Human Neuroblastoma Cells
Lee, J., Moehlenkamp, J. D., Hanson, J. M., & Johnson, J. A. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4106 · Cited by 124
Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity
Mendonca, P., & Soliman, K. F. A. (2020) · Antioxidants · doi:10.3390/antiox9080659 · Cited by 126
Antidiabetic Effects of Tea
Fu, Q.-Y., Li, Q., Lin, X.-M., Qiao, R.-Y., Yang, R., Li, X.-M., Dong, Z.-B., Xiang, L., Zheng, X., Lu, J., et al. (2017) · Molecules · doi:10.3390/molecules22050849 · Cited by 124
Nrf Transcription Factors in Keratinocytes Are Essential for Skin Tumor Prevention but Not for Wound Healing
Keller, U. A. D., Huber, M., Beyer, T. A., Kümin, A., Siemes, C., Braun, S., Bugnon, P., Mitropoulos, V., Johnson, D. A., Johnson, J. A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.10.3773-3784.2006 · Cited by 122
Pleiotropic Role of PPAR γ in Intracerebral Hemorrhage: An Intricate System Involving Nrf2, RXR , and NF ‐κB
Zhao, X., Gonzales, N. R., & Aronowski, J. A. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12350 · Cited by 122
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway
Wang, R., Paul, V. J., & Luesch, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.019 · Cited by 122
Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease
Brewer, A. C., Mustafi, S. B., Murray, T. V., Rajasekaran, N. S., & Benjamin, I. J. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4914 · Cited by 121
The role of natural products in revealing NRF2 function
Zhang, D. D., & Chapman, E. (2020) · Natural Product Reports · doi:10.1039/c9np00061e · Cited by 123
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
Lee, J.-M., Chan, K., Kan, Y. W., & Johnson, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403620101 · Cited by 120
Self-citation
Hyperoxia sensing: From molecular mechanisms to significance in disease
Gore, A., Muralidhar, M., Espey, M. G., Degenhardt, K., & Mantell, L. L. (2010) · Journal of Immunotoxicology · doi:10.3109/1547691x.2010.492254 · Cited by 123
Identification of Candidate Proteins Binding to Prion Protein
Yehiely, F., Bamborough, P., Costa, M. D., Perry, B. J., Thinakaran, G., Cohen, F. E., Carlson, G. A., & Prusiner, S. B. (1997) · Neurobiology of Disease · doi:10.1006/nbdi.1997.0130 · Cited by 121
Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation
Kim, H. M., Han, J. W., & Chan, J. Y. (2016) · Gene · doi:10.1016/j.gene.2016.03.002 · Cited by 122
Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: Binding-site selection and regulation of transcription
Johnsen, O., Murphy, P., Prydz, H., & Kolsto, A.-B. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.2.512 · Cited by 119
Therapeutic Approaches to Alzheimer’s Disease Through Modulation of NRF2
Bahn, G., & Jo, D. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-018-08523-5 · Cited by 118
Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics
Wang, L., Trasanidis, N., Wu, T., Dong, G., Hu, M., Bauer, D. E., & Pinello, L. (2023) · Nature Methods · doi:10.1038/s41592-023-01971-3 · Cited by 122
Mechanisms for Countering Oxidative Stress and Damage in Retinal Pigment Epithelium
Plafker, S. M., O'Mealey, G. B., & Szweda, L. I. (2012) · International review of cytology · doi:10.1016/b978-0-12-394309-5.00004-3 · Cited by 121
Nrf2–ARE signaling pathway and natural products for cancer chemoprevention
Zhao, C. R., Gao, Z. H., & Qu, X. J. (2010) · Cancer Epidemiology · doi:10.1016/j.canep.2010.06.012 · Cited by 114
Dimethyl fumarate treatment in multiple sclerosis: Recent advances in clinical and immunological studies
Diaz, G. M., Hupperts, R., Fraussen, J., & Somers, V. A. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.07.001 · Cited by 118
Nrf3 Negatively Regulates Antioxidant-response Element-mediated Expression and Antioxidant Induction of NAD(P)H:Quinone Oxidoreductase1 Gene
Kannan, S., & Jaiswal, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404984200 · Cited by 114
Keap1‐Nrf2 activation in the presence and absence of DJ‐1
Gan, L., Johnson, D. A., & Johnson, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07138.x · Cited by 113
Thioredoxin as a Neurotrophic Cofactor and an Important Regulator of Neuroprotection
Masutani, H., Bai, J., Kim, Y., & Yodoi, J. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:3:229 · Cited by 116
Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology
Igarashi, K., & Watanabe‐Matsui, M. (2014) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.232.229 · Cited by 115
Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals
Lee, D.-Y., Song, M.-Y., & Kim, E. (2021) · Antioxidants · doi:10.3390/antiox10050743 · Cited by 112
Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways
Akhter, N., Wilson, A., Arefanian, H., Thomas, R., Kochumon, S., Al‐Rashed, F., Abu‐Farha, M., Madhoun, A. S. A., Al‐Mulla, F., Ahmad, R., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015186 · Cited by 116
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
Morito, N., Yoh, K., Itoh, K., Hirayama, A., Kôyama, A., Yamamoto, M. P., & Takahashi, S. (2003) · Oncogene · doi:10.1038/sj.onc.1207024 · Cited by 115
A Combinatorial Code for Gene Expression Generated by Transcription Factor Bach2 and MAZR (MAZ-Related Factor) through the BTB/POZ Domain
Kobayashi, A., Yamagiwa, H., Hoshino, H., Muto, A., Sato, K., Morita, M., Hayashi, N., Yamamoto, M. P., & Igarashi, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1733-1746.2000 · Cited by 112
Downregulation of Reactive Oxygen Species in Apoptosis
Jeong, C.-H., & Joo, S. (2016) · Journal of Cancer Prevention · doi:10.15430/jcp.2016.21.1.13 · Cited by 98
Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2
Beury, D. W., Carter, K. A., Nelson, C. E., Sinha, P., Hanson, E. M., Nyandjo, M., Fitzgerald, P., Majeed, A., Wali, N., & Ostrand‐Rosenberg, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501785 · Cited by 115
The KEAP1-NRF2 System and Neurodegenerative Diseases
Uruno, A., & Yamamoto, M. P. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0234 · Cited by 113
Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2/Keap1 Interaction
Steel, R., Cowan, J., Payerne, E., O'Connell, M. A., & Searcey, M. (2012) · ACS Medicinal Chemistry Letters · doi:10.1021/ml300041g · Cited by 113
The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders
Hybertson, B. M., Gao, B., & Doan, A. (2014) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s35078 · Cited by 113
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
Alonso-Piñero, J. A., González-Rovira, A., Sánchez-Gomar, I., Moreno, J. A., & Durán-Ruiz, M. C. (2021) · Antioxidants · doi:10.3390/antiox10091463 · Cited by 120
Nrf2 Deficiency Exacerbated CLP-Induced Pulmonary Injury and Inflammation through Autophagy- and NF-κB/PPARγ-Mediated Macrophage Polarization
Luo, J., Wang, J., Zhang, J., Sang, A., Ye, X., Cheng, Z., & Li, X. (2022) · Cells · doi:10.3390/cells11233927 · Cited by 115
Deficiency of Nrf2 Accelerates the Effector Phase of Arthritis and Aggravates Joint Disease
Maicas, N., Ferrándiz, M. L., Brines, R., Ibáñez, L., Cuadrado, A., Koenders, M. I., van den Berg, W. B., & Alcaraz, M. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3835 · Cited by 110
Nrf2 promotes survival following exposure to ionizing radiation
Sekhar, K. R., & Freeman, M. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.035 · Cited by 109
The NRF2‐related interactome and regulome contain multifunctional proteins and fine‐tuned autoregulatory loops
Papp, D., Lenti, K., Módos, D., Fazekas, D., Dúl, Z., Türei, D., Földvári-Nagy, L., Nussinov, R., Csermely, P., & Korcsmaros, T. D. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.05.016 · Cited by 109
Thromboxanes: Synthase and Receptors
Shen, R., & Tai, H. (1998) · Journal of Biomedical Science · doi:10.1007/bf02253465 · Cited by 108
Molecular Mechanisms Involved in Enhancing HO-1 Expression: De-Repression by Heme and Activation by Nrf2, The "One-Two" Punch
Srisook, K., Kim, C., & Cha, Y. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1674 · Cited by 108
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.Preprint
Farmer, S. C., Sun, C., Winnier, G. E., Hogan, B. L. M., & Townes, T. M. (1997) · Genes & Development · doi:10.1101/gad.11.6.786 · Cited by 107
Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease
Wang, Y., Gao, L., Chen, J., Li, Q., Huo, L., Wang, Y., Wang, H., & Du, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.757161 · Cited by 107
Oxidative Stress Abolishes Leptomycin B-sensitive Nuclear Export of Transcription Repressor Bach2 That Counteracts Activation of Maf Recognition Element
Hoshino, H., Kobayashi, A., Yoshida, M., Kudo, N. R., Oyake, T., Motohashi, H., Hayashi, N., Yamamoto, M. P., & Igarashi, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15370 · Cited by 106
Effects of propofol on cancer development and chemotherapy: Potential mechanisms
Jiang, S., Liu, Y., Huang, L., Zhang, F., & Kang, R. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.04.009 · Cited by 105
Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?
Wang, R., Liang, L., Matsumoto, M., Iwata, K., Umemura, A., & He, F. (2023) · Biomolecules · doi:10.3390/biom13020353 · Cited by 112
Oxidative stress in neurodegeneration and available means of protection
Fatokun, A. A. (2008) · Frontiers in bioscience · doi:10.2741/2926 · Cited by 105
Cigarette Smoking Blocks the Protective Expression of Nrf2/ARE Pathway in Peripheral Mononuclear Cells of Young Heavy Smokers Favouring Inflammation
Garbin, U., Pasini, A. F., Stranieri, C., Cominacini, M., Pasini, A., Manfro, S., Lugoboni, F., Mozzini, C., Guidi, G. C., Faccini, G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008225 · Cited by 105
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages
Calcagno, D. M., Ng, R. P., Toomu, A., Zhang, C., Huang, K., Aguirre, A. D., Weissleder, R., Daniels, L. B., Fu, Z., & King, K. R. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz1974 · Cited by 107
NF-E2 Disrupts Chromatin Structure at Human β-Globin Locus Control Region Hypersensitive Site 2 In Vitro
Armstrong, J. A., & Emerson, B. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5634 · Cited by 104
Impaired megakaryopoiesis and behavioral defects inmafG-null mutant micePreprint
Shavit, J. A., Motohashi, H., Onodera, K., Akasaka, J.-E., Yamamoto, M. P., & Engel, J. D. (1998) · Genes & Development · doi:10.1101/gad.12.14.2164 · Cited by 104
Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)
Hahn, M. E., Timme‐Laragy, A. R., Karchner, S. I., & Stegeman, J. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.022 · Cited by 106
Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition
Hanssen, K. M., Haber, M., & Fletcher, J. I. (2021) · Drug Resistance Updates · doi:10.1016/j.drup.2021.100795 · Cited by 102
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction
Fujino, M., Nishio, Y., Ito, H., Tanaka, T., & Li, X. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.11.034 · Cited by 103
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review
Sova, M., & Saso, L. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s172612 · Cited by 104
Curcumin Restrains Oxidative Stress of After Intracerebral Hemorrhage in Rat by Activating the Nrf2/HO-1 Pathway
Duan, C., Wang, H., Jiao, D., Geng, Y., Wu, Q., Yan, H., & Li, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.889226 · Cited by 102
Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in heavy metals-induced oxidative stress
Tripathi, S., Kharkwal, G. B., Mishra, R., & Singh, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37545 · Cited by 103
The NRF2/Keap1 pathway as a therapeutic target in inflammatory bowel disease
Geertsema, S., Bourgonje, A. R., Fagundes, R. R., Gaćeša, R., Weersma, R. K., van Goor, H., Mann, G. E., Dijkstra, G. D. H., & Faber, K. N. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.07.008 · Cited by 101
Optimization of Fluorescently Labeled Nrf2 Peptide Probes and the Development of a Fluorescence Polarization Assay for the Discovery of Inhibitors of Keap1-Nrf2 Interaction
Inoyama, D., Chen, Y., Huang, X., Beamer, L. J., Kong, A. T., & Hu, L. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111430124 · Cited by 101
NFE2L3 (NRF3): the Cinderella of the Cap‘n’Collar transcription factors
Chevillard, G., & Blank, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0747-x · Cited by 105
PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders
Lv, J., Jiang, S., Yang, Z. P., Hu, W., Wang, Z., Li, T. X., & Yang, Y. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.03.004 · Cited by 102
Complexity of CNC Transcription Factors As Revealed by Gene Targeting of the Nrf3 Locus
Derjuga, A., Gourley, T. S., Holm, T. M., Heng, H. H. Q., Shivdasani, R. A., Ahmed, R., Andrews, N. C., & Blank, V. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3286-3294.2004 · Cited by 100
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans
Bornhorst, J., Chakraborty, S., Meyer, S., Lohren, H., Richter-Brockmann, S., Knight, A. L., Caldwell, K. A., Caldwell, G. A., Kärst, U., Schwerdtle, T., et al. (2013) · Metallomics · doi:10.1039/c3mt00325f · Cited by 101
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways
Sturm, C., & Wagner, A. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091890 · Cited by 101
Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2)
Tian, W., de la Vega, M. R., Schmidlin, C. J., Ooi, A., & Zhang, D. D. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000428 · Cited by 101
Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy
Sun, H., Wu, Z., Cao, L., Zhu, M., Liu, T.-T., Guo, L., Lin, Y., Nie, X.-W., & Bian, J. (2019) · Molecules · doi:10.3390/molecules24152857 · Cited by 103
Direct interaction of NF-E2 with hypersensitive site 2 of the β-globin locus control region in living cells
Forsberg, E. C., Downs, K. M., & Bresnick, E. H. (2000) · Blood · doi:10.1182/blood.v96.1.334 · Cited by 100
Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage
Kang, E. S., Woo, I. S., Kim, H. J., Eun, S. Y., Paek, K. S., Kim, H. J., Chang, K. C., Lee, J. H., Lee, H. T., Kim, J., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.006 · Cited by 100
Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes
Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., & Cui, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008391 · Cited by 99

Authors: Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W.
Affiliations: University of Cagliari (IT)
Howard Hughes Medical Institute (US)
ORCID: Moi, P
Asunis, I
Kan, Y W
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1994-10-11
Volume: 91
Issue: 21
Pages: 9926-9930
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.91.21.9926
PMC: PMC44930
OpenAlex: W1991265255
Cited by: 1,607
References: 41
Citations by year: 2026: 38 · 2025: 71 · 2024: 102 · 2023: 96 · 2022: 111 · 2021: 89 · 2020: 89 · 2019: 87 · 2018: 61 · 2017: 65 · 2016: 59 · 2015: 68 · 2014: 77 · 2013: 65 · 2012: 72
FWCI: 10.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
University of California, San Francisco
National Institute of Diabetes and Digestive and Kidney Diseases (DK16666)
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: Nrf2, NF-E2, beta-globin locus control region, AP-1, bZIP transcription factors, erythroid-specific transcription factors, acidic activation domain, transcriptional activation, beta-globin gene expression, K562 cells
MeSH terms: Amino Acid Sequence, Base Sequence, Binding Sites, Cell Line, DNA-Binding Proteins, Leukemia, Erythroblastic, Acute, Genes, Regulator, Multigene Family, Globins, Humans, Molecular Sequence Data, Oligodeoxyribonucleotides, Repetitive Sequences, Nucleic Acid, RNA, Messenger, Transcription Factors, Tumor Cells, Cultured, Blotting, Northern, Trans-Activators, Gene Library, Gene Expression, Zinc Fingers, Leucine Zippers, Open Reading Frames, Consensus Sequence, Sequence Homology, Amino Acid, Transcription Factor AP-1, Erythroid-Specific DNA-Binding Factors, NF-E2 Transcription Factor, NF-E2 Transcription Factor, p45 Subunit, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks