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Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy

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Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2

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Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding

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Allicin Ameliorates Cardiac Hypertrophy and Fibrosis through Enhancing of Nrf2 Antioxidant Signaling Pathways

Li, X.-H., Li, C., Zhi-gang, X., Hu, J., Lu, J.-M., Tian, R.-B., & Jia, W. P. (2012) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6415-z · Cited by 68 · see citing works

Conventional and Nanotechnology Based Approaches to Combat Chronic Obstructive Pulmonary Disease: Implications for Chronic Airway Diseases

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The pivotal role of nuclear factor erythroid 2-related factor 2 in diabetes-induced endothelial dysfunction

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Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins

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Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

Xing, Y., Niu, T., Wang, W., Li, J., Li, S., Janicki, J. S., Ruiz, S., Meyer, C. J., Wang, X. L., Tang, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044899 · Cited by 61 · see citing works

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity

Chin, M. P., Lee, C.-Y. I., Chuang, J.-C., Bumeister, R., Wigley, W. C., Sonis, S. T., Ward, K. W., & Meyer, C. J. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00387.2012 · Cited by 56 · see citing works

Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

Wong, M. H. L., Bryan, H. K., Copple, I. M., Jenkins, R. E., Chiu, P. H., Bibby, J., Berry, N. G., Kitteringham, N. R., Goldring, C. E., O’Neill, P. M., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01292 · Cited by 56 · see citing works

Elucidating the Role of Protandim and 6‐Gingerol in Protection Against Osteoarthritis

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Nrf2 deficiency aggravates Angiotensin II-induced cardiac injury by increasing hypertrophy and enhancing IL-6/STAT3-dependent inflammation

Chen, D., Li, Z., Bao, P., Chen, M., Zhang, M., Yan, F., Xu, Y., Ji, C., Hu, X., Sanchı́s, D., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.01.020 · Cited by 55 · see citing works

Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation

Choi, S. H., Park, S., Oh, C. J., Leem, J., Park, K., & Lee, I. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.07.005 · Cited by 55 · see citing works

Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction

Mapanga, R. F., Rajamani, U., Dlamini, N., Zungu-Edmondson, M., Kelly-Laubscher, R. F., Shafiullah, M., Wahab, A., Hasan, M. Y., Fahim, M. A., Rondeau, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047322 · Cited by 54 · see citing works

HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression

Hu, T., Schreiter, F. C., Bagchi, R. A., Tatman, P. D., Hannink, M., & McKinsey, T. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007006 · Cited by 50 · see citing works

The Interplay Between Mitochondrial Reactive Oxygen Species, Endoplasmic Reticulum Stress, and Nrf2 Signaling in Cardiometabolic Health

Bjorkman, S. H., & Pereira, R. O. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8220 · Cited by 46 · see citing works

HIV-1, reactive oxygen species, and vascular complications

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Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy

Qu, C., Li, B., Lai, Y., Li, H., Windust, A. J., Hofseth, L. J., Nagarkatti, M., Nagarkatti, P. S., Wang, X. L., Tang, D., et al. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.04.004 · Cited by 44 · see citing works

Chemical and Biological Mechanisms of Phytochemical Activation of NRF2 and Importance in Disease Prevention

Eggler, A. L., & Savinov, S. N. (2013) · Springer eBooks · doi:10.1007/978-3-319-00581-2_7 · Cited by 42 · see citing works

Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation

Imai, T., Takagi, T., Kitashoji, A., Yamauchi, K., Shimazawa, M., & Hara, H. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.001 · Cited by 42 · see citing works

The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

Bubb, K. J., Kok, C., Tang, O., Rasko, N. B., Birgisdottir, Å. B., Hansen, T., Ritchie, R. H., Bhindi, R., Reisman, S. A., Meyer, C. J., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.027 · Cited by 42 · see citing works

Diabetic nephropathy: What does the future hold?

Montero, R., Covic, A. C., Gnudi, L., & Goldsmith, D. J. A. (2015) · International Urology and Nephrology · doi:10.1007/s11255-015-1121-y · Cited by 41 · see citing works

Heme oxygenase-1: an emerging therapeutic target to curb cardiac pathology

Czibik, G., Dérumeaux, G., Sawaki, D., Valen, G., & Motterlini, R. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0450-9 · Cited by 39 · see citing works

Vascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection

Daiber, A., Steven, S., Euler, G., & Schulz, R. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210125155821 · Cited by 40 · see citing works

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase.

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A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy

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Relationship between oxidative stress and nuclear factor‑erythroid‑2‑related factor 2 signaling in diabetic cardiomyopathy (Review)

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Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

Wei, J., Zhu, H., Lord, G., Bhattachayya, M., Jones, B., Allaway, G. P., Biswal, S. S., Korman, B. D., Marangoni, R. G., Tourtellotte, W. G., et al. (2016) · Translational research · doi:10.1016/j.trsl.2016.12.002 · Cited by 36 · see citing works

Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

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Targeting Nrf2 by dihydro‐CDDO‐trifluoroethyl amide enhances autophagic clearance and viability of β‐cells in a setting of oxidative stress

Li, W., Wu, W., Song, H., Wang, F., Li, H., Chen, L., Lai, Y., Janicki, J. S., Ward, K. W., Meyer, C. J., et al. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.046 · Cited by 32 · see citing works

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Adamson, R. J., Payne, N. C., Bartual, S. G., Mazitschek, R., & Bullock, A. N. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.04.021 · Cited by 31 · see citing works

Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications

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Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor

Tamir, T. Y., Bowman, B. M., Agajanian, M. J., Goldfarb, D., Schrank, T. P., Stohrer, T., Hale, A., Siesser, P. F., Weir, S., Murphy, R. M., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.241356 · Cited by 29 · see citing works

Role of Nrf2 and Its Activators in Cardiocerebral Vascular Disease

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Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2

Li, B., Abdalrahman, A., Lai, Y., Janicki, J. S., Ward, K. W., Meyer, C. J., Wang, X. L., Tang, D., & Cui, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.101 · Cited by 22 · see citing works

Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation

Lopez, A. J., Lau, H., Li, S., & Ichii, H. (2020) · Antioxidants · doi:10.3390/antiox9040321 · Cited by 22 · see citing works

Urolithin A ameliorates diabetic retinopathy via activation of the Nrf2/HO-1 pathway

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The triterpenoids of Ganoderma tsugae prevent stress‐induced myocardial injury in mice

Kuok, Q.-Y., Yeh, C., Su, B., Hsu, P., Ni, H., Liu, M., & Mo, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200704 · Cited by 21 · see citing works

DHEA improves the antioxidant capacity of endometrial stromal cells and improves endometrium receptivity via androgen receptor

Qin, A., Qin, J., Jin, Y., Xie, W., Fan, L., Jiang, L., & Mo, F. (2016) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2016.01.016 · Cited by 21 · see citing works

CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus

Kim, J., Park, H., Lee, J., & Kang, T. (2020) · Cells · doi:10.3390/cells9051123 · Cited by 20 · see citing works

Bryonolic Acid Transcriptional Control of Anti-inflammatory and Antioxidant Genes in Macrophages in Vitro and in Vivo

Gatbonton-Schwager, T. N., Letterio, J. J., & Tochtrop, G. P. (2012) · Journal of Natural Products · doi:10.1021/np200823p · Cited by 19 · see citing works

Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice

Zhou, T., Qiu, S., Zhang, L., Li, Y., Zhang, J., Shen, D., Zhao, P., Yuan, L., Zhao, L., Duan, Y., et al. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0109 · Cited by 18 · see citing works

La voie Nrf2 en pathologie respiratoire

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A Novel Discovery: Holistic Efficacy at the Special Organ Level of Pungent Flavored Compounds from Pungent Traditional Chinese Medicine

Zhao, C. X., Cao, Y., Zhang, Y., & Qiao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030752 · Cited by 16 · see citing works

Myofibrillogenesis regulator-1 attenuated hypoxia/reoxygenation-induced apoptosis by inhibiting the PERK/Nrf2 pathway in neonatal rat cardiomyocytes

Tao, T., Wang, X.-R., Liu, M., Xu, F., & Liu, X. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1081-1 · Cited by 15 · see citing works

CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus

Kim, M.-J., Park, H., Choi, S.-H., Kong, M.-J., Kim, J.-E., & Kang, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194862 · Cited by 14 · see citing works

Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products

Wang, M., Sheng, K.-J., Fang, J.-C., Zhao, H., Lu, S., Liu, Z., & Chen, B.-T. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114829 · Cited by 14 · see citing works

Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway

Wang, N., Liu, X., Liu, K., Wang, K., & Zhang, H. (2023) · iScience · doi:10.1016/j.isci.2023.107443 · Cited by 12 · see citing works

CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats

Reisman, S. A., Ward, K. W., Klaassen, C. D., & Meyer, C. J. (2012) · Xenobiotica · doi:10.3109/00498254.2012.750022 · Cited by 12 · see citing works

The interregulatory circuit between non-coding RNA and apoptotic signaling in diabetic cardiomyopathy

Wu, H., Liu, Y., & Liu, C. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.06.011 · Cited by 8 · see citing works

Pentacyclic triterpenes, potential novel therapeutic approaches for cardiovascular diseases

Peng, D., Wang, A. H. J., Shi, W., & Lin, L. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01510-4 · Cited by 7 · see citing works

RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells

Tsai, T., Su, Y., Tsai, C.-Y., Wu, C., Lee, K.-T., & Hsu, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044006 · Cited by 6 · see citing works

Development of a High-Throughput Cul3-Keap1 Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Identifying Nrf2 Activators

Poore, D. D., Hofmann, G. A., Wolfe, L. A., Qi, H., Jiang, M., Fischer, M., Wu, Z., Sweitzer, T. D., Chakravorty, S. J., Donovan, B. T., et al. (2018) · SLAS DISCOVERY · doi:10.1177/2472555218807698 · Cited by 6 · see citing works

Inhibition of mitochondrial respiration has fundamentally different effects on proliferation, cell survival and stress response in immature versus differentiated cardiomyocyte cell lines

Grün, B., Tirre, M., Pyschny, S., Singh, V. P., Kehl, H.-G., Jux, C., & Drenckhahn, J. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1011639 · Cited by 5 · see citing works

Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation

Taira, J., Tsuda, R., Miyagi‐Shiohira, C., Noguchi, H., & Ogi, T. (2023) · Antioxidants · doi:10.3390/antiox12030693 · Cited by 5 · see citing works

Histone Deacetylases and Oxidative Stress: Role in Diabetic Cardiomyopathy

Patel, B. M. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_18 · Cited by 5 · see citing works

The best-laid plans

Harris, R. C. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00693.2012 · Cited by 4 · see citing works

RTA-dh404 decreased oxidative stress in mice ischemic limbs and augmented efficacy of therapeutic angiogenesis by intramuscular injection of adipose-derived regenerative cells in the limbs

Ishizaki, Y., Sasaki, K., Yoshikawa, T., Nakayoshi, T., Sasaki, M., Ohtsuka, M., Hatada-Katakabe, S., Takata, Y., & Fukumoto, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175422 · Cited by 2 · see citing works

MECHANISTIC STUDY OF USP15-DEPENDENT DEUBIQUITINATION AND CHARACTERIZATION OF NATURAL COMPOUNDS THAT MODULATE THE NRF2-KEAP1 ANTIOXIDANT RESPONSE

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La voie Nrf2 en pathologie

Boutten, A., Goven, D., Artaud-Macari, É., & Bonay, M. (2011)

BindingDB Entry 50005481: Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.

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Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in

Ichikawa, T., Li, J., Meyer, C. J., Janicki, J. S., Hannink, M., & Cui, T. (2013)

Triterpenoid Dihydro-CDDO-Trifluoroethyl Amide Protects against Maladaptive Cardiac Remodeling and Dysfunction in Mice: A Critical Role of Nrf2

Xing, Y., Niu, T., Wang, W., Li, J., Li, S., Janicki, J. S., Ruiz, S., Meyer, C. J., Wang, X. L., Tang, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044899 · Cited by 61 · see citing works

The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling

Bubb, K. J., Kok, C., Tang, O., Rasko, N. B., Birgisdottir, Å. B., Hansen, T., Ritchie, R. H., Bhindi, R., Reisman, S. A., Meyer, C. J., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.027 · Cited by 42 · see citing works

Nrf2 at the heart of oxidative stress and cardiac protection

Chen, Q. M., & Maltagliati, A. J. (2017) · Physiological Genomics · doi:10.1152/physiolgenomics.00041.2017 · Cited by 474 · see citing works

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

Shanmugam, G., Challa, A. K., Litovsky, S. H., Devarajan, A., Wang, D., Jones, D. P., Darley-Usmar, V. M., & Rajasekaran, N. S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101212 · Cited by 83 · see citing works