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Altered inflammatory responses in leukotriene-deficient mice.
Open accessAbstract
Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.
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Citations
Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
A Second Leukotriene B4 Receptor, Blt2
Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., & Shimizu, T. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.421 · Cited by 538
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
Ishii, S., & Shimizu, T. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(99)00016-8 · Cited by 384
Importance of Dietary γ-Linolenic Acid in Human Health and Nutrition
Fan, Y.-Y., & Chapkin, R. S. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.9.1411 · Cited by 384
Metadata
- Authors
- Goulet, J. L., Snouwaert, J. N., Latour, A. M., Coffman, T. M., & Koller, B. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-12-20
- Volume
- 91
- Issue
- 26
- Pages
- 12852-12856
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087339573
- Cited by
- 189
- References
- 0
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Goulet, J. L., Snouwaert, J. N., Latour, A. M., Coffman, T. M., & Koller, B. H. (1994). Altered inflammatory responses in leukotriene-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.26.12852
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