The DOI matches its Crossref record.
Oxymetry deep in tissues with low-frequency electron paramagnetic resonance.
Open accessAbstract
We have measured the oxygen concentration in the body water of murine FSa and NFSa fibrosarcomas using a new method for quantitative oxygen concentration determination deep in the tissues of a living animal. The measurement uses unusually low-frequency electron paramagnetic spectroscopy sensitive to substrate 7 cm deep in tissue, partially deuterated spin probes (spin labels of molecular mass 195, approximating that of glucose) whose distribution compartment can be targeted with facile adduct substitution, and novel analytic techniques. We show that the water-compartment oxygen concentration of the tumors decreases as the tumor size increases and also shows a trend to decrease as radiobiologic hypoxia increases. An oxymetric spectral image of the tumor is presented. The technique will improve with larger human tissue samples. It provides the potential to quantitatively assess tissue hypoxia in ischemic or preischemic states in stroke and myocardial infarction. It will allow direct assessment of tumor hypoxia to determine the usefulness of radiation and chemotherapy adjuvants directed to hypoxic cell compartments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
Hockel, M., & Vaupel, P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.266 · Cited by 2,662
Tumor hypoxia and malignant progression
Vaupel, P., Mayer, A., & Höckel, M. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)81023-1 · Cited by 496
Biological detection by optical oxygen sensing
Papkovsky, D. B., & Dmitriev, R. I. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60131e · Cited by 444
Krishna, M. C., English, S., Yamada, K., Yoo, J., Murugesan, R., Devasahayam, N., Cook, J. A., Golman, K., Ardenkjaer-Larsen, J. H., Subramanian, S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042671399 · Cited by 304
Trityl-based EPR probe with enhanced sensitivity to oxygen
Bobko, A. A., Dhimitruka, I., Eubank, T. D., Marsh, C. B., Zweier, J. L., & Khramtsov, V. V. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.007 · Cited by 63
Metadata
- Authors
- Halpern, H. J., Yu, C., Peric, M., Barth, E., Grdina, D. J., & Teicher, B. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-12-20
- Volume
- 91
- Issue
- 26
- Pages
- 13047-13051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052171115
- Cited by
- 195
- References
- 0
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. https://app.cochat.ai/papers/10.1073/pnas.91.26.13047
- The paper
- Halpern, H. J., Yu, C., Peric, M., Barth, E., Grdina, D. J., & Teicher, B. A. (1994). Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.26.13047
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
