The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration
Open accessAbstract
An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2–7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO 2 (oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (<10 mmHg; 1 mmHg = 133 Pa). Oxygenation of tumors was enhanced on carbogen (95% O 2 /5% CO 2 ) inhalation. The pO 2 measurements from OMRI were found to be in agreement with those obtained by independent polarographic measurements using a pO 2 Eppendorf electrode. This work illustrates that anatomically coregistered pO 2 maps of tumors can be readily obtained by combining the good anatomical resolution of water proton-based MRI, and the superior pO 2 sensitivity of EPR. OMRI affords the opportunity to perform noninvasive and repeated pO 2 measurements of the same animal with useful spatial (≈1 mm) and temporal (2 min) resolution, making this method a powerful imaging modality for small animal research to understand tumor physiology and potentially for human applications.
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Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
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Self-citationSuccessively activatable ultrasensitive probe for imaging tumour acidity and hypoxia
Zheng, X., Mao, H., Huo, D., Wu, W., Liu, B., & Jiang, X. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0057 · Cited by 210
Metadata
- Authors
- Krishna, M. C., English, S., Yamada, K., Yoo, J., Murugesan, R., Devasahayam, N., Cook, J. A., Golman, K., Ardenkjaer-Larsen, J. H., Subramanian, S., & Mitchell, J. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 4
- Pages
- 2216-2221
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157854449
- Cited by
- 304
- References
- 20
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Krishna, M. C., English, S., Yamada, K., Yoo, J., Murugesan, R., Devasahayam, N., Cook, J. A., Golman, K., Ardenkjaer-Larsen, J. H., Subramanian, S., & Mitchell, J. B. (2002). Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.042671399
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