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Time-dependent diffusion of water in a biologicalmodel system.
Open accessAbstract
Packed erythrocytes are ideally suited as a model system for the study of water diffusion in biological tissue, because cell size, membrane permeability, and extracellular volume fraction can be varied independently. We used a pulsed-field-gradient spin echo NMR technique to measure the time-dependent diffusion coefficient D(t) in packed erythrocytes. The long-time diffusion constant, D(eff), depends sensitively on the extracellular volume fraction. This may explain the drop in D(eff) during the early stages of brain ischemia, where just minutes after an ischemic insult the extra-cellular volume in the affected region of the brain is significantly reduced. Using an effective medium formula, we estimate the erythrocyte membrane permeability, in good agreement with measurements on isolated cells. From the short-time behavior of D(t), we determine the surface-to-volume ratio of the cells, approximately (0.72 micron)-1.
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Cited by
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Diffusion tensor imaging: Concepts and applications
Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1076 · Cited by 3,547
Diffusion in Brain Extracellular Space
Syková, E., & Nicholson, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00027.2007 · Cited by 1,481
MRI quantification of non-gaussian water diffusion by kurtosis analysis
Jensen, J. H., & Helpern, J. A. (2010) · NMR in Biomedicine · doi:10.1002/nbm.1518 · Cited by 1,251
Guo, A. C., Cummings, T. J., Dash, R. C., & Provenzale, J. M. (2002) · Radiology · doi:10.1148/radiol.2241010637 · Cited by 688
Metadata
- Authors
- Latour, L. L., Svoboda, K., Mitra, P. P., & Sotak, C. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02-15
- Volume
- 91
- Issue
- 4
- Pages
- 1229-1233
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037420975
- Cited by
- 515
- References
- 0
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- green
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