Diffusion tensor imaging: Concepts and applications
Abstract
The success of diffusion magnetic resonance imaging (MRI) is deeply rooted in the powerful concept that during their random, diffusion‐driven displacements molecules probe tissue structure at a microscopic scale well beyond the usual image resolution. As diffusion is truly a three‐dimensional process, molecular mobility in tissues may be anisotropic, as in brain white matter. With diffusion tensor imaging (DTI), diffusion anisotropy effects can be fully extracted, characterized, and exploited, providing even more exquisite details on tissue microstructure. The most advanced application is certainly that of fiber tracking in the brain, which, in combination with functional MRI, might open a window on the important issue of connectivity. DTI has also been used to demonstrate subtle abnormalities in a variety of diseases (including stroke, multiple sclerosis, dyslexia, and schizophrenia) and is currently becoming part of many routine clinical protocols. The aim of this article is to review the concepts behind DTI and to present potential applications. J. Magn. Reson. Imaging 2001;13:534–546. © 2001 Wiley‐Liss, Inc.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Even where more sophisticated models are available, DTI often remains the first analytic layer because it provides a stable orientation field and familiar summary indices.
“Even where more sophisticated models are available, DTI often remains the first analytic layer because it provides a stable orientation field and a familiar set of summary indices (Le Bihan et al., 2001).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Le Bihan et al., 2001
Noise floor effects, Gibbs ringing, eddy currents, susceptibility distortions, and free-water partial volume can bias tensor estimates unless explicitly controlled.
“Noise floor effects, Gibbs ringing, eddy currents, susceptibility distortions, and free-water partial volume can all bias tensor estimates unless explicitly controlled (Beaulieu, 2002; Le Bihan et al., 2001; Tournier et al., 2011).”
From 40 Years of diffusion MRI in the brain: From history to emerging frontiers (2026) · cites this paper as Le Bihan et al., 2001
DTI is the most commonly employed diffusion model and utilizes the magnitude and orientation of anisotropic water diffusion to estimate the WM structure of brain tissue, producing maps of macroscopic axonal organization.
“Diffusion tensor imaging (DTI) is the most commonly employed diffusion model and utilizes the magnitude and orientation of anisotropic water diffusion to estimate the WM structure of brain tissue, thereby producing maps of macroscopic axonal organization in the brain (Basser and Pierpaoli, 1996; Le Bihan et al., 2001; Mori and Zhang, 2006).”
From The role of myelination in measures of white matter integrity: Combination of diffusion tensor imaging and two-photon microscopy of CLARITY intact brains (2017) · cites this paper as Le Bihan et al., 2001
Diffusion tensor imaging is a magnetic resonance imaging technique that estimates white matter in vivo.
“Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that estimates white matter in vivo (Bihan et al., 2001) and is increasingly being used to study the biology of addiction.”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Bihan et al., 2001
DTI is an MRI method that estimates white matter in the living human brain.
“Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that estimates white matter in vivo (Bihan et al., 2001)”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Bihan et al., 2001
Cites
Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient
Stejskal, E. O., & Tanner, J. E. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1695690 · Cited by 8,239 · see citing works
MR diffusion tensor spectroscopy and imaging
Basser, P. J., Mattiello, J., & LeBihan, D. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80775-1 · Cited by 5,970 · see citing works
Self-citationBasser, P. J., & Pierpaoli, C. (1996) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1996.0086 · Cited by 4,306 · see citing works
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912 · see citing works
Estimation of the Effective Self-Diffusion Tensor from the NMR Spin Echo
Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656 · see citing works
Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199902)45:2 · Cited by 3,479 · see citing works
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664 · see citing works
Toward a quantitative assessment of diffusion anisotropy
Pierpaoli, C. M., & Basser, P. J. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360612 · Cited by 2,392 · see citing works
Tracking neuronal fiber pathways in the living human brain
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., McKinstry, R. C., Burton, H., & Raichle, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10422 · Cited by 1,774 · see citing works
Moseley, M. E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M. F., & Weinstein, P. R. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140218 · Cited by 1,644 · see citing works
Diffusion in Solids, Liquids, Gases
Jost, W. (1952) · Zeitschrift für Physikalische Chemie · doi:10.1515/zpch-1952-2011-229 · Cited by 1,274 · see citing works
Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system.
Moseley, M. E., Cohen, Y., Kucharczyk, J. R., Mintorovitch, J., Asgari, H. S., Wendland, M. F., Tsuruda, J. S., & Norman, D. M. (1990) · Radiology · doi:10.1148/radiology.176.2.2367658 · Cited by 1,132 · see citing works
Extracellular space structure revealed by diffusion analysis
Nicholson, C., & Syková, E. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01261-2 · Cited by 914 · see citing works
Moseley, M. E., Kucharczyk, J. R., Mintorovitch, J., Cohen, Y., Kurhanewicz, J. V., Derugin, N., Asgari, H. S., & Norman, D. M. (2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.45-12.s8 · Cited by 890 · see citing works
Fast magnetic resonance diffusion-weighted imaging of acute human stroke
Warach, S., Chien, D., Li, W., Ronthal, M., & Edelman, R. R. (1992) · Neurology · doi:10.1212/wnl.42.9.1717 · Cited by 881 · see citing works
Nicholson, C., & Phillips, J. M. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013981 · Cited by 785 · see citing works
Sorensen, A. G., Buonanno, F. S., González, R. G., et al. (1996) · Radiology · doi:10.1148/radiology.199.2.8668784 · Cited by 740 · see citing works
Microstructure of Temporo-Parietal White Matter as a Basis for Reading Ability
Klingberg, T., Hedehus, M., Temple, E., Salz, T., Gabrieli, J. D. E., Moseley, M. E., & Poldrack, R. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)80911-3 · Cited by 729 · see citing works
Hüppi, P. S., Maier, S. E., Peled, S., Zientara, G. P., Barnes, P. D., Jolesz, F. A., & Volpe, J. J. (1998) · Pediatric Research · doi:10.1203/00006450-199810000-00019 · Cited by 722 · see citing works
Neil, J. J., Shiran, S. I., McKinstry, R. C., Schefft, G. L., Snyder, A. Z., Almli, C. R., Akbudak, E., Aronovitz, J. A., Miller, J. P., Lee, B. C., et al. (1998) · Radiology · doi:10.1148/radiology.209.1.9769812 · Cited by 645 · see citing works
Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis
Werring, D. J., Clark, C. A., Barker, G. J., Thompson, A. J., & Miller, D. H. (1999) · Neurology · doi:10.1212/wnl.52.8.1626 · Cited by 621 · see citing works
Self-citationGonzález, R. G., Schaefer, P. W., Buonanno, F. S., Schwamm, L. H., Budzik, R. F., Rordorf, G. A., Wang, B., Sorensen, A. G., & Koroshetz, W. J. (1999) · Radiology · doi:10.1148/radiology.210.1.r99ja02155 · Cited by 595 · see citing works
A simplified method to measure the diffusion tensor from seven MR images
Basser, P. J., & Pierpaoli, C. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390610 · Cited by 584 · see citing works
Echo-planar imaging of intravoxel incoherent motion.
Turner, R., Bihan, D. L., Maier, J. K., Vavrek, R. M., Hedges, L. K., & Pekar, J. J. (1990) · Radiology · doi:10.1148/radiology.177.2.2217777 · Cited by 575 · see citing works
Niendorf, T., Dijkhuizen, R. M., Norris, D. G., van Lookeren Campagne, M., & Nicolay, K. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910360607 · Cited by 570 · see citing works
Time-dependent diffusion of water in a biologicalmodel system.
Latour, L. L., Svoboda, K., Mitra, P. P., & Sotak, C. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1229 · Cited by 517 · see citing works
Yamada, I., Aung, W., Himeno, Y., Nakagawa, T., & Shibuya, H. (1999) · Radiology · doi:10.1148/radiology.210.3.r99fe17617 · Cited by 513 · see citing works
Anisotropic diffusion in human white matter: demonstration with MR techniques in vivo.
Chenevert, T. L., Brunberg, J. A., & Pipe, J. G. (1990) · Radiology · doi:10.1148/radiology.177.2.2217776 · Cited by 503 · see citing works
An analytical model of restricted diffusion in bovine optic nerve
Stanisz, G. J., Wright, G. A., Henkelman, R. M., & Szafer, A. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370115 · Cited by 501 · see citing works
Molecular diffusion, tissue microdynamics and microstructure
Bihan, D. L. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080711 · Cited by 497 · see citing works
Posterior leukoencephalopathy without severe hypertension
Ay, H., Buonanno, F. S., Schaefer, P. W., et al. (1998) · Neurology · doi:10.1212/wnl.51.5.1369 · Cited by 471 · see citing works
Lövblad, K., Baird, A. E., Gottfried Schlaug, A., Benfield, A., Siewert, B., Voetsch, B., Connor, A., Burzynski, C., Edelman, R. R., & Warach, S. J. (1997) · Annals of Neurology · doi:10.1002/ana.410420206 · Cited by 467 · see citing works
Scollan, D. F., Holmes, A., Winslow, R. L., & Forder, J. R. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.6.h2308 · Cited by 458 · see citing works
Molecular diffusion nuclear magnetic resonance imaging.
Bihan, D. L. (1991) · PubMed · Cited by 438 · see citing works
Baur, A., Stäbler, A., Brüning, R., Bartl, R., Krödel, A., Reiser, M. F., & Deimling, M. (1998) · Radiology · doi:10.1148/radiology.207.2.9577479 · Cited by 438 · see citing works
Regularization of Diffusion-Based Direction Maps for the Tracking of Brain White Matter Fascicles
Poupon, C., Clark, C., Frouin, V., Régis, J. M., Isabelle Bloch, A., Bihan, D. L., & Mangin, J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0607 · Cited by 426 · see citing works
Self-citationWater diffusion compartmentation and anisotropy at high b values in the human brain
Clark, C. A., & Bihan, D. L. (2000) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200012)44:6 · Cited by 424 · see citing works
Self-citationWater diffusion and acute stroke
van Gelderen, P., de Vleeschouwer, M. H. M., Despres, D., Pekar, J. J., van Zijl, P. C. M., & MOONEN, C. T. W. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910310209 · Cited by 407 · see citing works
Diffusion and Perfusion Magnetic Resonance Imaging
Bihan, D. L., & Warach, S. J. (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199509000-00032 · Cited by 399 · see citing works
Makris, N., Worth, A. J., Papadimitriou, G., Stakes, J. W., Caviness, V. S., Kennedy, D. N., Pandya, D. Ν., Kaplan, E., Sorensen, A. G., Wu, O., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410420617 · Cited by 377 · see citing works
Fiber Crossing in Human Brain Depicted with Diffusion Tensor MR Imaging
Wiegell, M. R., Larsson, H. B. W., & Wedeen, V. J. (2000) · Radiology · doi:10.1148/radiology.217.3.r00nv43897 · Cited by 376 · see citing works
Multi-component apparent diffusion coefficients in human brain
Mulkern, R. V., Guðbjartsson, H., Westin, C., Zengingönül, H. P., Gartner, W., Guttmann, C. R. G., Robertson, R. L., Kyriakos, W. E., Schwartz, R. B., Holtzman, D. H., et al. (1999) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199902)12:1 · Cited by 371 · see citing works
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
Buchsbaum, M., Tang, C. Y., Peled, S., Gudbjartsson, H., Lu, D.-F., Hazlett, E., Downhill, J., Haznedar, M., Fallon, J., & Atlas, S. (1998) · NeuroReport · doi:10.1097/00001756-199802160-00013 · Cited by 369 · see citing works
Barzó, P., Marmarou, A., Fatouros, P. P., Hayasaki, K., & Corwin, F. D. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.87.6.0900 · Cited by 368 · see citing works
Schaefer, P. W., Buonanno, F. S., González, R. G., et al. (1997) · Stroke · doi:10.1161/01.str.28.5.1082 · Cited by 349 · see citing works
Focal liver masses: characterization with diffusion-weighted echo-planar MR imaging.
Namimoto, T., Yamashita, Y., Sumi, S., et al. (1997) · Radiology · doi:10.1148/radiology.204.3.9280252 · Cited by 349 · see citing works
The spatial mapping of translational diffusion coefficients by the NMR imaging technique
Taylor, D. G., & Bushell, M. C. (1985) · Physics in Medicine and Biology · doi:10.1088/0031-9155/30/4/009 · Cited by 344 · see citing works
Diffusion-weighted MR imaging in hypertensive encephalopathy: clues to pathogenesis.
Schwartz, R. B., Mulkern, R. V., Guðbjartsson, H., et al. (1998) · PubMed · Cited by 330 · see citing works
MR diffusion imaging of human intracranial tumours
Krabbe, K. S., Gideon, P., Wagn, P., Hansen, U., Thomsen, C., & Madsen, F. (1997) · Neuroradiology · doi:10.1007/s002340050450 · Cited by 327 · see citing works
Foong, J. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.2.242 · Cited by 316 · see citing works
Ichikawa, T., Haradome, H., Hachiya, J., et al. (1998) · American Journal of Roentgenology · doi:10.2214/ajr.170.2.9456953 · Cited by 316 · see citing works
Characterization of White Matter Damage in Ischemic Leukoaraiosis with Diffusion Tensor MRI
Jones, D. K., Lythgoe, D. J., Horsfield, M. A., Simmons, A., Williams, S., & Markus, H. S. (1999) · Stroke · doi:10.1161/01.str.30.2.393 · Cited by 307 · see citing works
Self-diffusion NMR imaging using stimulated echoes
Merboldt, K., Hänicke, W., & Frahm, J. (1985) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(85)90111-8 · Cited by 307 · see citing works
Conturo, T. E., McKinstry, R. C., Akbudak, E., & Robinson, B. H. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350319 · Cited by 293 · see citing works
Diffusion Weighting by the Trace of the Diffusion Tensor within a Single Scan
Mori, S., & van Zijl, P. C. M. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330107 · Cited by 280 · see citing works
MR color mapping of myelin fiber orientation
Douek, P., Turner, R., Pekar, J., Patronas, N., & Bihan, D. L. (1991) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199111000-00003 · Cited by 274 · see citing works
Cruz, A., & Green, B. G. (2000) · Nature · doi:10.1038/35002581 · Cited by 271 · see citing works
Kim, S., Rostrup, E., Larsson, H. B. W., Ogawa, S., & Paulson, O. B. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199906)41:6 · Cited by 267 · see citing works
Tievsky, A. L., Ptak, T., & Farkas, J. E. (1999) · PubMed · Cited by 251 · see citing works
Cleveland, G., Chang, D. C., Hazlewood, C. F., & Rorschach, H. E. (1976) · Biophysical Journal · doi:10.1016/s0006-3495(76)85754-2 · Cited by 243 · see citing works
Beaulieu, C., & Allen, P. S. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320506 · Cited by 240 · see citing works
The b matrix in diffusion tensor echo‐planar imaging
Mattiello, J., Basser, P. J., & Bihan, D. L. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370226 · Cited by 238 · see citing works
Changes in water diffusion and relaxation properties of rat cerebrum during status epilepticus
Zhong, J., Petroff, O. A. C., Prichard, J. W., & Gore, J. C. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300214 · Cited by 238 · see citing works
Imagerie de diffusion in-vivo par résonance magnétique nucléaire
Bihan, D. L., & Breton, E. (1985) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 232 · see citing works
Analytical Expressions for the b Matrix in NMR Diffusion Imaging and Spectroscopy
Mattiello, J., Basser, P. J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series A · doi:10.1006/jmra.1994.1103 · Cited by 228 · see citing works
MR Imaging of Anisotropically Restricted Diffusion of Water in the Nervous System
Hajnal, J. V., Doran, M., Hall, A. S., Collins, A. G., Oatridge, A., Pennock, J. M., oung, I. R., & Bydder, G. M. (1991) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199101000-00001 · Cited by 226 · see citing works
Sakuma, H., Nomura, Y., Takeda, K., Tagami, T., Nakagawa, T., Tamagawa, Y., Ishii, Y., & Tsukamoto, T. (1991) · Radiology · doi:10.1148/radiology.180.1.2052700 · Cited by 215 · see citing works
Chabriat, H., Pappata, S., Poupon, C., Clark, C. A., Vahedi, K., Poupon, F., Mangin, J. F., Pachot-Clouard, M., Jobert, A., Le Bihan, D., et al. (1999) · Stroke · doi:10.1161/01.str.30.12.2637 · Cited by 214 · see citing works
Self-citationA Comparative Study of Acquisition Schemes for Diffusion Tensor Imaging Using MRI
Papadakis, N. G., Xing, D., Huang, C. L.-H., Hall, L. D., & Carpenter, T. A. (1999) · Journal of Magnetic Resonance · doi:10.1006/jmre.1998.1673 · Cited by 203 · see citing works
Optimised diffusion-weighting for measurement of apparent diffusion coefficient (ADC) in human brain
Xing, D., Papadakis, N. G., Huang, C. L.-H., Lee, V. M., Carpenter, T. A., & Hall, L. D. (1997) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(97)00037-4 · Cited by 180 · see citing works
Diffusion-weighted MR imaging of the hippocampus and temporal white matter in Alzheimer's disease
Hanyu, H., Sakurai, H., Iwamoto, T., Takasaki, M., Shindo, H., & Abe, K. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00043-4 · Cited by 175 · see citing works
Callaghan, P. T., & Söderman, O. (1983) · The Journal of Physical Chemistry · doi:10.1021/j100233a019 · Cited by 158 · see citing works
Clark, C. A., Werring, D. J., & Miller, D. H. (2000) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(200001)43:1 · Cited by 150 · see citing works
Self-citationNew Histological and Physiological Stains Derived from Diffusion‐Tensor MR Images
Basser, P. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46192.x · Cited by 144 · see citing works
Norris, D. G., Niendorf, T., & Leibfritz, D. (1994) · NMR in Biomedicine · doi:10.1002/nbm.1940070703 · Cited by 142 · see citing works
Spreading waves of decreased diffusion coefficient lifter cortical stimulation in the rat brain
Latour, L. L., Hasegawa, Y., Formato, J. E., Fisher, M., & Sotak, C. H. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320207 · Cited by 136 · see citing works
Baratti, C., Barnett, A. S., & Pierpaoli, C. M. (1999) · Radiology · doi:10.1148/radiology.210.1.r99ja09133 · Cited by 131 · see citing works
Beaulieu, C., Fenrich, F. R., & Allen, P. S. (1998) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(98)00151-9 · Cited by 129 · see citing works
MOONEN, C. T. W., Pekar, J. J., de Vleeschouwer, M. H. M., van Gelderen, P., van Zijl, P. C. M., & Despres, D. (1991) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910190223 · Cited by 129 · see citing works
Is water diffusion restricted in human brain white matter? An echo-planar NMR imaging study
Bihan, D. L., Turner, R., & Douek, P. (1993) · Neuroreport · doi:10.1097/00001756-199307000-00012 · Cited by 128 · see citing works
Werring, D. J., Clark, C., Barker, G. J., Miller, D., Parker, G. J. M., Brammer, M. J., Bullmore, E. T., Giampietro, V., & Thompson, A. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.6.863 · Cited by 120 · see citing works
Self-citationPitfalls and potential of clinical diffusion-weighted MR imaging in acute stroke.
Warach, S. J., Boska, M. D., & Welch, K. M. A. (1997) · PubMed · Cited by 117 · see citing works
Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain
Hasegawa, Y., Latour, L. L., Formato, J. E., Sotak, C. H., & Fisher, M. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.23 · Cited by 116 · see citing works
Diffusion and perfusion magnetic resonance imaging in brain tumors
Bihan, D. L., Douek, P., Argyropoulou, M. I., et al. (1993) · Topics in Magnetic Resonance Imaging · doi:10.1097/00002142-199300520-00005 · Cited by 116 · see citing works
Hsu, E. W., & Mori, S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340210 · Cited by 114 · see citing works
Pilatus, U., Shim, H., Artemov, D., Davis, D., van Zijl, P. C. M., & Glickson, J. D. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370605 · Cited by 114 · see citing works
Evolution of anisotropic diffusion in the developing rat corpus callosum
Voříšek, I., & Syková, E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.2.912 · Cited by 113 · see citing works
In vivo measurement of diffusion and pseudo-diffusion in skeletal muscle at rest and after exercise
Morvan, D. (1995) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)00096-l · Cited by 94 · see citing works
Ford, J. C., Hackney, D. B., Lavi, E., Phillips, M. D., & Patel, U. J. (1998) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880080405 · Cited by 93 · see citing works
Invited. Ultrafast MR imaging of the abdomen: Echo planar imaging and diffusion‐weighted imaging
Yamashita, Y., Tang, Y., & Takahashi, M. (1998) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1880080216 · Cited by 92 · see citing works
Diffusion magnetic resonance imaging in multiple sclerosis.
Horsfield, M. A., Larsson, H. B. W., Jones, D. K., & Gass, A. (1998) · PubMed · Cited by 90 · see citing works
McIntosh, L. M., Granberg, K., Brière, K. M., & Anderson, J. E. (1998) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199802)11:1 · Cited by 90 · see citing works
Diffusion anisotropy in excised normal rat spinal cord measured by NMR microscopy
Inglis, B. A., Yang, L., Wirth, E. D., et al. (1997) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(96)00242-1 · Cited by 88 · see citing works
MR Imaging of Anisotropically Restricted Diffusion in the Brain of Neonates and Infants
Rutherford, M., Cowan, F. M., Manzur, A. Y., Dubowitz, L. M. S., Pennock, J. M., Hajnal, J. V., YOUNG, I. R., & Bydder, G. M. (1991) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199103000-00002 · Cited by 87 · see citing works
Iwasawa, T., Matoba, H., Ogi, A., et al. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380317 · Cited by 85 · see citing works
MRI-Based Topographic Parcellation of Human Cerebral White Matter
Meyer, J. W., Makris, N., Bates, J. F., Caviness, V. S., & Kennedy, D. N. (1999) · NeuroImage · doi:10.1006/nimg.1998.0383 · Cited by 84 · see citing works
Increased Water Diffusion in Cerebral White Matter in Alzheimer’s Disease
Hanyu, H., Shindo, H., Kakizaki, D., Abe, K., Iwamoto, T., & Takasaki, M. (2009) · Gerontology · doi:10.1159/000213874 · Cited by 83 · see citing works
Diffusion imaging of human breast
Englander, S. A., Uluğ, A. M., Brem, R. F., Glickson, J. D., & van Zijl, P. C. M. (1997) · NMR in Biomedicine · doi:10.1002/(sici)1099-1492(199710)10:7 · Cited by 82 · see citing works
Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene
Chabriat, H., Vahedi, K., Clark, C., Poupon, C., Ducros, A., Denier, C., Bihan, D. L., & Bousser, M. (2000) · Neurology · doi:10.1212/wnl.54.2.510 · Cited by 76 · see citing works
Self-citationRegularization of MR diffusion tensor maps for tracking brain white matter bundles
Poupon, C., Mangin, J., Frouin, V., Régis, J. M., Poupon, F., Pachot‐Clouard, M., Bihan, D. L., & Isabelle Bloch, A. (1998) · Lecture notes in computer science · doi:10.1007/bfb0056234 · Cited by 75 · see citing works
Self-citationBusch, E. W., Hoehn‐Berlage, M., Eis, M., et al. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080203 · Cited by 71 · see citing works
Differentiation of dys- and demyelination using diffusional anisotropy
Ono, J., Harada, K., Mano, T., Sakurai, K., & Okada, S. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(96)00249-4 · Cited by 65 · see citing works
Gulani, V., Iwamoto, G. A., Jiang, H., Shimony, J. S., WEBB, A. G., & Lauterbur, P. C. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380603 · Cited by 64 · see citing works
Quantitative diffusion imaging in implanted human breast tumors
Maier, C. F., Paran, Y., Bendel, P., Rutt, B. K., & Degani, H. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370417 · Cited by 64 · see citing works
MR SPECTROSCOPY AND DIFFUSION-WEIGHTED MR IMAGING IN FOCAL BRAIN LESIONS IN AIDS
Chang, L., & Ernst, T. (1997) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00462-9 · Cited by 63 · see citing works
Effects of diffusion anisotropy on lesion delineation in a rat model of cerebral ischemia
Lythgoe, M. F., Busza, A. L., Calamante, F., Sotak, C. H., King, M. D., Bingham, A. C., Williams, S. R., & Gadian, D. G. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380421 · Cited by 63 · see citing works
Pfeuffer, J., Dreher, W., Syková, E., & Leibfritz, D. (1998) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(98)00107-6 · Cited by 60 · see citing works
Calculation of Apparent Diffusion Coefficients (ADCs) in Brain Using Two-Point and Six-Point Methods
Burdette, J. H., Elster, A. D., & Ricci, P. E. (1998) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199809000-00023 · Cited by 59 · see citing works
Takeda, K., Nomura, Y., Sakuma, H., Tagami, T., Okuda, Y., & Nakagawa, T. (1997) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199701000-00001 · Cited by 59 · see citing works
Diffusion-weighted MRI of myelination in the rat brain following treatment with gonadal hormones
Prayer, D., Roberts, T. P. L., Barkovich, A. J., Prayer, L., Kucharczyk, J. R., Moseley, M. E., & Arieff, A. I. (1997) · Neuroradiology · doi:10.1007/s002340050416 · Cited by 56 · see citing works
Dreher, W., Kühn, B., Gyngell, M. L., et al. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390605 · Cited by 54 · see citing works
The Apparent Diffusion Coefficient of Water in Gray and White Matter of the Infant Brain
Toft, P. B., Leth, H., Peitersen, B., Lou, H. C., & Thomsen, C. E. (1996) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199611000-00029 · Cited by 54 · see citing works
Integrated analysis of diffusion and relaxation of water in blood
Li, J. G., Stanisz, G. J., & Henkelman, R. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400112 · Cited by 49 · see citing works
Diffusion-weighted MR imaging of acute cerebral ischemia
Li, T., Chen, Z. G., & Hindmarsh, T. (1998) · Acta Radiologica · doi:10.1080/02841859809172209 · Cited by 39 · see citing works
Assaf, Y., & Cohen, Y. (1996) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1996.0125 · Cited by 34 · see citing works
Gilbert, R. J., Reese, T. G., Daftary, S., et al. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.2.g363 · Cited by 30 · see citing works
Shrager, R. I., & Basser, P. J. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400121 · Cited by 29 · see citing works
Diffusion into human intervertebral disks studied with MR and gadoteridol.
Akansel, G., Haughton, V. M., Papke, R. A., et al. (1997) · PubMed · Cited by 27 · see citing works
Advances in pediatric neuroimaging
Zimmerman, R. A., Haselgrove, J. C., Wang, Z., Hunter, J. V., Morriss, M. C., Hoydu, A. K., & Bilaniuk, L. T. (1998) · Brain and Development · doi:10.1016/s0387-7604(98)00023-0 · Cited by 27 · see citing works
Single‐shot diffusion‐weighted trace imaging on a clinical scanner
Chun, T., Uluğ, A. M., & van Zijl, P. C. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910400415 · Cited by 24 · see citing works
PFG NMR self-diffusion measurements in microporous adsorbents
Kärger, J., & Pfeifer, H. (1994) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)91525-3 · Cited by 20 · see citing works
Seo, Y., Shinar, H., Morita, Y., & Navon, G. (1999) · Magnetic Resonance in Medicine · doi:10.1002/(sici)1522-2594(199909)42:3 · Cited by 19 · see citing works
Ikezaki, K., Takahashi, M., Koga, H., et al. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6837-0_52 · Cited by 17 · see citing works
Diffusion-Weighted MRI in Severe Leukoaraiosis
Okada, K., Wu, L., & Kobayashi, S. (1999) · Stroke · doi:10.1161/01.str.30.2.478 · Cited by 17 · see citing works
Diffusion and Perfusion Magnetic Resonance Imaging: Applications to Functional MRI
Martin, D. S. (1996) · Radiology · doi:10.1148/radiology.198.3.860 · Cited by 16 · see citing works
Practical design of a high‐strength breast gradient coil
Maier, C. F., Nikolov, H. N., Chu, K. C., et al. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390309 · Cited by 13 · see citing works
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Jones (1999) · doi:10.1002/(sici)1522-2594(199907)42:1
Flagged first, then by citations
Cited by
Sorted by citations
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173 · see citing works
Van Dijk, K. R. A., Hedden, T., Venkataraman, A., Evans, K. C., Lazar, S. W., & Buckner, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00783.2009 · Cited by 1,844 · see citing works
Neuroplasticity Subserving Motor Skill Learning
Dayan, E., & Cohen, L. G. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.008 · Cited by 1,408 · see citing works
Sex differences in the structural connectome of the human brain
Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Hakonarson, H., Gur, R. E., Gur, R. C., & Verma, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316909110 · Cited by 1,223 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
Log-Euclidean metrics for fast and simple calculus on diffusion tensors
Arsigny, V., Fillard, P., Pennec, X., & Ayache, N. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20965 · Cited by 1,113 · see citing works
Single subject prediction of brain disorders in neuroimaging: Promises and pitfalls
Arbabshirani, M. R., Plis, S., Sui, J., & Calhoun, V. D. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.079 · Cited by 912 · see citing works
Dubois, J., Dehaene-Lambertz, G., Kulikova, S., Poupon, C., Hüppi, P. S., & Hertz-Pannier, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.044 · Cited by 851 · see citing works
Self-citationAbnormal Brain Structure Implicated in Stimulant Drug Addiction
Ersche, K. D., Jones, P. S., Williams, G. B., Turton, A. J., Robbins, T. W., & Bullmore, E. T. (2012) · Science · doi:10.1126/science.1214463 · Cited by 546 · see citing works
Learning in the fast lane: new insights into neuroplasticity
Sagi, Y., Tavor, I., Hofstetter, S., Tzur-Moryosef, S., Blumenfeld-Katzir, T., & Assaf, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.025 · Cited by 517 · see citing works
Connectivity-Based Parcellation of Broca's Area
Anwander, A., Tittgemeyer, M., von Cramon, D., Friederici, A., & Knosche, T. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk034 · Cited by 531 · see citing works
Internet gaming addiction: current perspectives
Kuss, D. (2013) · Psychology Research and Behavior Management · doi:10.2147/prbm.s39476 · Cited by 498 · see citing works
Bazarian, J. J., Zhong, J., Blyth, B., Zhu, T., Kavcic, V., & Peterson, D. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0241 · Cited by 487 · see citing works
Understanding the Physiopathology Behind Axial and Radial Diffusivity Changes—What Do We Know?
Winklewski, P. J., Sabisz, A., Naumczyk, P., Jodzio, K., Szurowska, E., & Szarmach, A. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00092 · Cited by 463 · see citing works
Eluvathingal, T. J., Chugani, H. T., Behen, M. E., Juhász, C., Muzik, O., Maqbool, M., Chugani, D. C., & Makki, M. (2006) · Pediatrics · doi:10.1542/peds.2005-1727 · Cited by 451 · see citing works
Thomalla, G., Glauche, V., Koch, M. A., Beaulieu, C., Weiller, C., & Röther, J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.03.041 · Cited by 438 · see citing works
Internet and Gaming Addiction: A Systematic Literature Review of Neuroimaging Studies
Kuss, D. J., & Griffiths, M. D. (2012) · Brain Sciences · doi:10.3390/brainsci2030347 · Cited by 437 · see citing works
Genetics of brain fiber architecture and intellectual performance
Chiang, M.-C., Barysheva, M., Shattuck, D. W., Lee, A. D., Madsen, S. K., Avedissian, C., Klunder, A. D., Toga, A. W., McMahon, K. L., de Zubicaray, G. I., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4184-08.2009 · Cited by 406 · see citing works
Machine learning in major depression: from classification to treatment outcome prediction
Gao, S., Calhoun, V. D., & Sui, J. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13048 · Cited by 370 · see citing works
Diffusion tensor imaging of post mortem multiple sclerosis brain
Schmierer, K., Wheeler-Kingshott, C. A. M., Boulby, P. A., Scaravilli, F., Altmann, D. R., Barker, G. J., Tofts, P. S., & Miller, D. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.010 · Cited by 395 · see citing works
Gliomas: diffusion kurtosis MR imaging in grading
Van Cauter, S., Veraart, J., Sijbers, J., Peeters, R. R., Himmelreich, U., De Keyzer, F., Van Gool, S. W., Van Calenbergh, F., De Vleeschouwer, S., Van Hecke, W., et al. (2012) · Radiology · doi:10.1148/radiol.12110927 · Cited by 340 · see citing works
Overview of quantitative susceptibility mapping
Deistung, A., Schweser, F., & Reichenbach, J. R. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3569 · Cited by 338 · see citing works
DTI mapping of human brain connectivity: Statistical fibre tracking and virtual dissection
Hagmann, P., Thiran, J.-P., Jonasson, L., Vandergheynst, P., Clarke, S., Maeder, P., & Meuli, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00142-3 · Cited by 326 · see citing works
Disordered connectivity in the autistic brain: Challenges for the ‘new psychophysiology’
Rippon, G., Brock, J., Brown, C., & Boucher, J. (2007) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2006.03.012 · Cited by 308 · see citing works
Cubon, V. A., Putukian, M., Boyer, C., & Dettwiler, A. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2010.1430 · Cited by 297 · see citing works
Martino, J., De Witt Hamer, P. C., Berger, M. S., Lawton, M. T., Arnold, C. M., de Lucas, E. M., & Duffau, H. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0386-5 · Cited by 280 · see citing works
Schulte, T., Sullivan, E. V., Müller-Oehring, E. M., Adalsteinsson, E., & Pfefferbaum, A. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi020 · Cited by 275 · see citing works
Bosch, B., Arenaza-Urquijo, E. M., Rami, L., Sala-Llonch, R., Junqué, C., Solé-Padullés, C., Peña-Gómez, C., Bargalló, N., Molinuevo, J. L., & Bartrés-Faz, D. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.004 · Cited by 272 · see citing works
Bohland, J. W., Wu, C., Barbas, H., Bokil, H., Bota, M., Breiter, H. C., Cline, H. T., Doyle, J. C., Freed, P. J., Greenspan, R. J., et al. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000334 · Cited by 261 · see citing works
Imaging Patterns of Brain Development and their Relationship to Cognition
Erus, G., Battapady, H., Satterthwaite, T. D., Hakonarson, H., Gur, R. E., Davatzikos, C., & Gur, R. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht425 · Cited by 226 · see citing works
Roalf, D. R., Quarmley, M., Elliott, M. A., Satterthwaite, T. D., Vandekar, S. N., Ruparel, K., Gennatas, E. D., Calkins, M. E., Moore, T. M., Hopson, R., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.068 · Cited by 199 · see citing works
Is diffusion anisotropy an accurate monitor of myelination?
Mädler, B., Drabycz, S. A., Kolind, S. H., Whittall, K. P., & MacKay, A. L. (2008) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.01.047 · Cited by 227 · see citing works
Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review
van Elk, M., & Yaden, D. B. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104793 · Cited by 221 · see citing works
Quantitative tract-based white matter development from birth to age 2 years
Geng, X., Gouttard, S., Sharma, A., Gu, H., Styner, M., Lin, W., Gerig, G., & Gilmore, J. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.057 · Cited by 212 · see citing works
Birur, B., Kraguljac, N. V., Shelton, R. C., & Lahti, A. C. (2017) · npj Schizophrenia · doi:10.1038/s41537-017-0013-9 · Cited by 203 · see citing works
Feldstein Ewing, S. W., Sakhardande, A., & Blakemore, S.-J. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.06.011 · Cited by 185 · see citing works
Chang, E. H., Argyelan, M., Aggarwal, M., Chandon, T.-S. S., Karlsgodt, K. H., Mori, S., & Malhotra, A. K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.11.068 · Cited by 186 · see citing works
Anterior thalamic radiation integrity in schizophrenia: A diffusion-tensor imaging study
Mamah, D., Conturo, T. E., Harms, M. P., Akbudak, E., Wang, L., McMichael, A. R., Gado, M. H., Barch, D. M., & Csernansky, J. G. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.04.013 · Cited by 185 · see citing works
Martino, J., De Witt Hamer, P. C., Vergani, F., Brogna, C., de Lucas, E. M., Vázquez‐Barquero, A., García‐Porrero, J. A., & Duffau, H. (2011) · Journal of Anatomy · doi:10.1111/j.1469-7580.2011.01414.x · Cited by 174 · see citing works
Seok, J.-H., Park, H.-J., Chun, J.-W., Lee, S.-K., Cho, H. S., Kwon, J. S., & Kim, J.-J. (2007) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.02.002 · Cited by 168 · see citing works
CASCIO, C. J., GERIG, G., & PIVEN, J. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000246064.93200.e8 · Cited by 167 · see citing works
Robust clustering of massive tractography datasets
Guevara, P., Poupon, C., Rivière, D., Cointepas, Y., Descoteaux, M., Thirion, B., & Mangin, J.-F. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.028 · Cited by 157 · see citing works
Self-citationNoninvasive brain stimulation in traumatic brain injury
Demirtas-Tatlidede, A., Vahabzadeh-Hagh, A. M., Bernabeu, M., Tormos, J. M., & Pascual-Leone, A. (2012) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0b013e318217df55 · Cited by 149 · see citing works
Peper, J. S., Mandl, R. C. W., Braams, B. R., de Water, E., Heijboer, A. C., Koolschijn, P. C. M. P., & Crone, E. A. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs163 · Cited by 144 · see citing works
A DTI-Derived Measure of Cortico-Cortical Connectivity
Zalesky, A., & Fornito, A. (2009) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2008.2012113 · Cited by 141 · see citing works
Holtmannspötter, M., Peters, N., Opherk, C., Martin, D., Herzog, J., Brückmann, H., Sämann, P., Gschwendtner, A., & Dichgans, M. (2005) · Stroke · doi:10.1161/01.str.0000189696.70989.a4 · Cited by 140 · see citing works
Callosal Contributions to Simultaneous Bimanual Finger Movements
Bonzano, L., Tacchino, A., Roccatagliata, L., Abbruzzese, G., Mancardi, G. L., & Bove, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4076-07.2008 · Cited by 136 · see citing works
Myelin, myelin-related disorders, and psychosis
Mighdoll, M. I., Tao, R., Kleinman, J. E., & Hyde, T. M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.09.040 · Cited by 135 · see citing works
Is Alzheimer’s a disease of the white matter?
Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835ed6e8 · Cited by 137 · see citing works
White matter microstructure in opiate addiction
Bora, E., Yücel, M., Fornito, A., Pantelis, C., Harrison, B. J., Cocchi, L., Pell, G., & Lubman, D. I. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00266.x · Cited by 130 · see citing works
Impairments in Cognitive Function and Brain Connectivity in Severe Asymptomatic Carotid Stenosis
Cheng, H.-L., Lin, C.-J., Soong, B.-W., Wang, P.-N., Chang, F.-C., Wu, Y.-T., Chou, K.-H., Lin, C.-P., Tu, P.-C., & Lee, I.-H. (2012) · Stroke · doi:10.1161/strokeaha.111.645614 · Cited by 128 · see citing works
Bazan, N. G., Eady, T. N., Khoutorova, L., Atkins, K. D., Hong, S., Lu, Y., Zhang, C., Jun, B., Obenaus, A., Fredman, G., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.04.007 · Cited by 121 · see citing works
Chronic traumatic encephalopathy: Where are we and where are we going?
Mez, J., Stern, R. A., & McKee, A. C. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0407-7 · Cited by 120 · see citing works
Molko, N., Pappata, S., Mangin, J.-F., Poupon, F., LeBihan, D., Bousser, M.-G., & Chabriat, H. (2002) · Stroke · doi:10.1161/01.str.0000041681.25514.22 · Cited by 116 · see citing works
Self-citationBilleci, L., Calderoni, S., Tosetti, M., Catani, M., & Muratori, F. (2012) · BMC Neurology · doi:10.1186/1471-2377-12-148 · Cited by 116 · see citing works
Lacunar Infarcts Are the Main Correlate With Cognitive Dysfunction in CADASIL
Liem, M. K., van der Grond, J., Haan, J., van den Boom, R., Ferrari, M. D., Knaap, Y. M., Breuning, M. H., van Buchem, M. A., Middelkoop, H. A. M., & Lesnik Oberstein, S. A. J. (2007) · Stroke · doi:10.1161/01.str.0000257968.24015.bf · Cited by 114 · see citing works
White matter lesions defined by diffusion tensor imaging in older adults
Back, S. A., Kroenke, C. D., Sherman, L. S., Lawrence, G., Gong, X., Taber, E. N., Sonnen, J. A., Larson, E. B., & Montine, T. J. (2011) · Annals of Neurology · doi:10.1002/ana.22484 · Cited by 109 · see citing works
Brouwer, R. M., Mandl, R. C. W., Schnack, H. G., van Soelen, I. L. C., van Baal, G. C., Peper, J. S., Kahn, R. S., Boomsma, D. I., & Pol, H. E. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032316 · Cited by 107 · see citing works
Churchill, N. W., Caverzasi, E., Graham, S. J., Hutchison, M. G., & Schweizer, T. A. (2017) · Human Brain Mapping · doi:10.1002/hbm.23658 · Cited by 104 · see citing works
Functional magnetic resonance imaging: A review of methodological aspects and clinical applications
Hennig, J., Speck, O., Koch, M. A., & Weiller, C. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10330 · Cited by 100 · see citing works
Dalby, R. B., Frandsen, J., Chakravarty, M. M., Ahdidan, J., Sørensen, L., Rosenberg, R., Videbech, P., & Østergaard, L. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.06.008 · Cited by 96 · see citing works
Hampton, W. H., Hanik, I. M., & Olson, I. R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.005 · Cited by 95 · see citing works
In vivo imaging of tau pathology using multi-parametric quantitative MRI
Wells, J. A., O'Callaghan, J. M., Holmes, H. E., Powell, N. M., Johnson, R. A., Siow, B., Torrealdea, F., Ismail, O., Walker-Samuel, S., Golay, X., et al. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.02.023 · Cited by 93 · see citing works
Onnink, A. M. H., Zwiers, M. P., Hoogman, M., Mostert, J. C., Dammers, J., Kan, C. C., Vasquez, A. A., Schene, A. H., Buitelaar, J., & Franke, B. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.008 · Cited by 93 · see citing works
Zalesky, A. (2011) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2010.06.027 · Cited by 88 · see citing works
Quantitative tractography metrics of white matter integrity in diffusion-tensor MRI
Correia, S., Lee, S. Y., Voorn, T., Tate, D. F., Paul, R. H., Zhang, S., Salloway, S. P., Malloy, P. F., & Laidlaw, D. H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.022 · Cited by 85 · see citing works
Suh, H. S., Lee, W. H., & Kim, T.-S. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/21/6961 · Cited by 84 · see citing works
Lawrence, K. E., Levitt, J. G., Loo, S. K., Ly, R., Yee, V., O’Neill, J., Alger, J., & Narr, K. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.01.010 · Cited by 77 · see citing works
Hernando, K. A., Szaflarski, J. P., Ver Hoef, L. W., Lee, S., & Allendorfer, J. B. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.02.022 · Cited by 74 · see citing works
Qin, J., Wei, M., Liu, H., Yan, R., Luo, G., Yao, Z., & Lu, Q. (2014) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25036 · Cited by 73 · see citing works
Neurite orientation dispersion and density imaging of mouse brain microstructure
Wang, N., Zhang, J., Cofer, G., Qi, Y., Anderson, R. J., White, L. E., & Allan Johnson, G. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01877-x · Cited by 69 · see citing works
Li, L., Jiang, Q., Ding, G., Zhang, L., Zhang, Z. G., Li, Q., Panda, S., Kapke, A., Lu, M., Ewing, J. R., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.527713 · Cited by 67 · see citing works
Vuoksimaa, E., Panizzon, M. S., Hagler Jr, D. J., Hatton, S. N., Fennema‐Notestine, C., Rinker, D., Eyler, L. T., Franz, C. E., Lyons, M. J., Neale, M. C., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23502 · Cited by 58 · see citing works
Schermuly, I., Fellgiebel, A., Wagner, S., Yakushev, I., Stoeter, P., Schmitt, R., Knickenberg, R. J., Bleichner, F., & Beutel, M. E. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.05.001 · Cited by 67 · see citing works
Spoletini, I., Cherubini, A., Di Paola, M., Banfi, G., Rüsch, N., Martinotti, G., Bria, P., Rubino, I. A., Siracusano, A., Caltagirone, C., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.011 · Cited by 62 · see citing works
Gogliettino, A. R., Potenza, M. N., & Yip, S. W. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.02.015 · Cited by 56 · see citing works
White Matter Heritability Using Diffusion Tensor Imaging in Neonatal Brains
Geng, X., Prom-Wormley, E. C., Perez, J., Kubarych, T., Styner, M., Lin, W., Neale, M. C., & Gilmore, J. H. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.14 · Cited by 53 · see citing works
Kaufman, J. A., Ahrens, E. T., Laidlaw, D. H., Zhang, S., & Allman, J. M. (2005) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20264 · Cited by 54 · see citing works
Alcohol intake and brain white matter in middle aged men: microscopic and macroscopic differences
McEvoy, L. K., Fennema-Notestine, C., Elman, J. A., Eyler, L. T., Franz, C. E., Hagler, D. J., Hatton, S. N., Lyons, M. J., Panizzon, M. S., Dale, A. M., et al. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.02.006 · Cited by 41 · see citing works
Lischke, A., Domin, M., Freyberger, H. J., Grabe, H. J., Mentel, R., Bernheim, D., & Lotze, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00196 · Cited by 35 · see citing works
White Matter Alterations in Cognitively Normal apoE ɛ2 Carriers: Insight into Alzheimer Resistance?
Chiang, G. C., Zhan, W., Schuff, N., & Weiner, M. W. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2984 · Cited by 25 · see citing works
Toller, G., Mandelli, M. L., Cobigo, Y., Rosen, H. J., Kramer, J. H., Miller, B. L., Gorno-Tempini, M. L., & Rankin, K. P. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.102994 · Cited by 23 · see citing works
Diffusion tensor magnetic resonance imaging of the brain in app transgenic mice: A cohort study.
Müller, H.-P., Kassubek, J., Vernikouskaya, I., Ludolph, A. C., Stiller, D., & Rasche, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067630 · Cited by 22 · see citing works
Park, S., Lee, J.-M., Kim, J.-W., Kwon, H., Cho, S.-C., Han, D. H., Cheong, J. H., & Kim, B.-N. (2016) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.09.012 · Cited by 17 · see citing works
Wang, S., Zuo, L., Jiang, T., Peng, P., Chu, S., & Xiao, D. (2017) · Neurological Research · doi:10.1080/01616412.2017.1379277 · Cited by 12 · see citing works
Shen, Q., Heikkinen, N., Kärkkäinen, O., Gröhn, H., Könönen, M., Liu, Y., Kaarre, O., Zhang, Z., Tan, C., Tolmunen, T., et al. (2019) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2019.111003 · Cited by 11 · see citing works
Den Braber, A., Van ‘t Ent, D., Stoffers, D., Linkenkaer-Hansen, K., I. Boomsma, D., & J.C. de Geus, E. (2013) · International Journal of Psychological Research · doi:10.21500/20112084.712 · Cited by 11 · see citing works
40 Years of diffusion MRI in the brain: From history to emerging frontiers
Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365
“Even where more sophisticated models are available, DTI often remains the first analytic layer because it provides a stable orientation field and a familiar set of summary indices ( Le Bihan et al., 2001).”
Wang, W., Wen, X., Zhang, Y., Wang, H., Hu, L., Tan, C., & Liu, Z. (2026) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2026.1924031
- Authors
- Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2001-03-21
- Volume
- 13
- Issue
- 4
- Pages
- 534-546
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W2120259577
- Cited by
- 3,547
- References
- 128
- Citations by year
- 2026: 89 · 2025: 131 · 2024: 139 · 2023: 136 · 2022: 135 · 2021: 182 · 2020: 157 · 2019: 145 · 2018: 159 · 2017: 179 · 2016: 190 · 2015: 173 · 2014: 211 · 2013: 179 · 2012: 181
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- diffusion tensor imaging, diffusion MRI, diffusion anisotropy, white matter microstructure, tractography, brain connectivity, functional MRI, stroke, multiple sclerosis, dyslexia, schizophrenia, clinical application
- MeSH terms
- Brain Diseases, Diffusion, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
