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RanGAP1 induces GTPase activity of nuclear Ras-related Ran.
Open accessAbstract
The nuclear Ras-related protein Ran binds guanine nucleotide and is involved in cell cycle regulation. Models of the signal pathway predict Ran to be active as Ran.GTP at the initiation of S phase upon activation by the nucleotide exchange factor RCC1 and to be inactivated for the onset of mitosis by hydrolysis of bound GTP. Here a nuclear homodimeric 65-kDa protein, RanGAP1, is described, which we believe to be the immediate antagonist of RCC1. It was purified from HeLa cell lysates and induces GTPase activity of Ran, but not Ras, by more than 3 orders of magnitude. The Ran mutant Q69L, modeled after RasQ61L, which is unable to hydrolyze bound GTP, is insensitive to RanGAP1.
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Citations
Cited by
Mahajan, R., Delphin, C., Guan, T., Gerace, L., & Melchior, F. (1997) · Cell · doi:10.1016/s0092-8674(00)81862-0 · Cited by 1,256
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Zhang, K., Donnelly, C. J., Haeusler, A. R., Grima, J. C., Machamer, J. B., Steinwald, P., Daley, E. L., Miller, S. J., Cunningham, K. M., Vidensky, S., et al. (2015) · Nature · doi:10.1038/nature14973 · Cited by 982
Purification of a Ran-interacting protein that is required for protein import into the nucleus.
Moore, M. S., & Blobel, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10212 · Cited by 320
Silljé, H. H. W., Nagel, S., Körner, R., & Nigg, E. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.070 · Cited by 267
HURP is part of a Ran-dependent complex involved in spindle formation
Koffa, M. D., Casanova, C. M., Santarella, R., Köcher, T., Wilm, M., & Mattaj, I. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.056 · Cited by 250
Metadata
- Authors
- Bischoff, F. R., Klebe, C., Kretschmer, J., Wittinghofer, A., & Ponstingl, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-03-29
- Volume
- 91
- Issue
- 7
- Pages
- 2587-2591
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106243159
- Cited by
- 523
- References
- 0
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Bischoff, F. R., Klebe, C., Kretschmer, J., Wittinghofer, A., & Ponstingl, H. (1994). RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.7.2587
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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