The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts.
Open accessAbstract
Oxidative stress of human skin fibroblasts by treatment with ultraviolet A (UVA) radiation has been shown to lead to an increase in levels of the heme catabolizing enzyme heme oxygenase 1 [heme, hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating), EC 1.14.99.3] and the iron storage protein ferritin. Here we show that human skin fibroblasts, preirradiated with UVA, sustain less membrane damage during a subsequent exposure to UVA radiation than cells that had not been preirradiated. Pretreating cells with heme oxygenase 1 antisense oligonucleotide inhibited the irradiation-dependent induction of both the heme oxygenase I enzyme and ferritin and abolished the protective effect of preirradiation. Inhibition of the UVA preirradiation-dependent increase in ferritin, but not heme oxygenase, with desferrioxamine also abolished the protection. This identifies heme oxygenase 1 as a crucial enzymatic intermediate in an oxidant stress-inducible antioxidant defense mechanism, involving ferritin, in human skin fibroblasts.
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Cited by
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Mechanisms of Cell Protection by Heme Oxygenase-1
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Free heme toxicity and its detoxification systems in human
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Metadata
- Authors
- Vile, G. F., Basu-Modak, S., Waltner, C., & Tyrrell, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-03-29
- Volume
- 91
- Issue
- 7
- Pages
- 2607-2610
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993596487
- Cited by
- 517
- References
- 18
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. https://app.cochat.ai/papers/10.1073/pnas.91.7.2607
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- Vile, G. F., Basu-Modak, S., Waltner, C., & Tyrrell, R. M. (1994). Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.7.2607
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
