The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.
Open accessAbstract
The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, calcineurin, and a Ca2+ release channel, the ryanodine receptor. Based on our findings in regeneration models that levels of FKBPs during neural regeneration parallel those of growth-associated protein GAP43, a calcineurin substrate that regulates neurite extension, we examined effects of FK506 in PC12 rat pheochromocytoma cells and in rat sensory ganglia. FK506 enhances neurite outgrowth in both systems by increasing sensitivity to nerve growth factor. Blockade of FK506 actions in sensory ganglia by rapamycin, an FK506 antagonist, establishes that these effects involve FKBPs. Rapamycin itself stimulates neurite outgrowth in PC12 cells. These drug effects are detected at subnanomolar concentrations, suggesting therapeutic application in diseases involving neural degeneration.
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Self-citationThe mechanism of action of cyclosporin A and FK506
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Clinical Outcome following Nerve Allograft Transplantation
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Antioxidant Therapies for Traumatic Brain Injury
Hall, E. D., Vaishnav, R. A., & Mustafa, A. G. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.10.021 · Cited by 390
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
Shirane, M., & Nakayama, K. I. (2003) · Nature Cell Biology · doi:10.1038/ncb894 · Cited by 318
Sawa, A., Khan, A. A., Hester, L. D., & Snyder, S. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11669 · Cited by 317
Self-citationIndustrial natural product chemistry for drug discovery and development
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Metadata
- Authors
- Lyons, W. E., George, E. B., Dawson, T. M., Steiner, J. P., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-12
- Volume
- 91
- Issue
- 8
- Pages
- 3191-3195
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2135128039
- Cited by
- 285
- References
- 46
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyons, W. E., George, E. B., Dawson, T. M., Steiner, J. P., & Snyder, S. H. (1994). Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.8.3191
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
