The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.
Open accessAbstract
We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets. Here we examined the effect of rat Reg protein on pancreatic beta-cell replication using both 90% depancreatized rats and isolated islets. The depancreatized rats that received i.p. administration of recombinant rat Reg protein (1 mg/kg per day) for 2 months showed amelioration of the surgical diabetes, as evidenced by a significant decrease in blood glucose with an increased beta-cell mass in the residual pancreas. In isolated rat islets, Reg protein (18-180 nM: 0.3-3 micrograms/ml) significantly increased [3H]thymidine incorporation into the nuclei of beta cells. These results indicate that Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus.
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Cites
Stereological Principles for Morphometry in Electron Microscopic Cytology
Weibel, E. R. (1969) · International Review of Cytology · doi:10.1016/s0074-7696(08)61637-x · Cited by 1,946
A novel gene activated in regenerating islets.
Terazono, K., Yamamoto, H., Takasawa, S., Shiga, K., Yonemura, Y., Tochino, Y., & Okamoto, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69176-8 · Cited by 469
Self-citationYonemura, Y., Takashima, T., Miwa, K., Miyazaki, I., Yamamoto, H., & Okamoto, H. (1984) · Diabetes · doi:10.2337/diab.33.4.401 · Cited by 170
Self-citationUnno, M., Yonekura, H., Nakagawara, K., Watanabe, T., Miyashita, H., Moriizumi, S., Okamoto, H., Itoh, T., & Teraoka, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82347-x · Cited by 136
Self-citationTerazono, K., Uchiyama, Y., Ide, M., Watanabe, T., Yonekura, H., Yamamoto, H., & Okamoto, H. (1990) · Diabetologia · doi:10.1007/bf00404804 · Cited by 129
Self-citationExpression ofreg/PSP, a Pancreatic Exocrine Gene: Relationship to Changes in Islet β-Cell Mass
Miyaura, C., Chen, L., APPEL, M. C., Alam, T., Inman, L. R., Hughes, S. D., Milburn, J. L., Unger, R. H., & Newgard, C. B. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-2-226 · Cited by 79
Molecular Biology of the Islets of Langerhans
(1990) · Cambridge University Press eBooks · doi:10.1017/cbo9780511600340 · Cited by 53
Francis, P. J., Southgate, J. L., Wilkin, T. J., & Bone, A. J. (1992) · Diabetologia · doi:10.1007/bf00400923 · Cited by 46
Hellerström, C., Andersson, A., & GUNNARSSON, R. (1976) · PubMed · Cited by 40
Yonemura, Y., Takashima, T., Matsuda, Y., Miwa, K., Sugiyama, K., Miyazaki, I., Yamamoto, H., & Okamoto, H. (1988) · International Journal of Pancreatology · doi:10.1007/bf02788225 · Cited by 17
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Cited by
Garcia-Ocaña, A., Takane, K. K., Syed, M. A., Philbrick, W. M., Vasavada, R. C., & Stewart, A. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1226 · Cited by 247
Identification of a three-biomarker panel in urine for early detection of pancreatic adenocarcinoma
Radon, T. P., Massat, N. J., Jones, R., Alrawashdeh, W., Dumartin, L., Ennis, D., Duffy, S. W., Kocher, H. M., Pereira, S. P., Guarner (posthumous), L., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2467 · Cited by 203
Metadata
- Authors
- Watanabe, T., Yonemura, Y., Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama, K., Moriizumi, S., Unno, M., Tanaka, O., & Kondo, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-26
- Volume
- 91
- Issue
- 9
- Pages
- 3589-3592
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977445442
- Cited by
- 260
- References
- 11
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Watanabe, T., Yonemura, Y., Yonekura, H., Suzuki, Y., Miyashita, H., Sugiyama, K., Moriizumi, S., Unno, M., Tanaka, O., & Kondo, H. (1994). Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.9.3589
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
