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Erythropoietin receptor mRNA expression in human endothelial cells.
Open accessAbstract
A previous report demonstrated that endothelial cells have erythropoietin receptors and respond to this hormone with enhanced proliferation. The present study demonstrates the existence of mRNA for erythropoietin receptor in human umbilical vein endothelial cells. We have reverse transcribed mRNA of endothelial cells and then used different PCR primers to amplify erythropoietin receptor target cDNA between exons 5 and 6 as well as 3-5 in addition to an internal standard DNA fragment. Correspondence of size as well as location of restriction endonuclease scission (Ava II) was used in comparing the amplified fragments of human endothelial cell erythropoietin receptor to those of two human erythroleukemia cell lines, OCIM1 and K562. No alpha- or gamma-globin mRNA was detected in endothelial cells but was readily demonstrable in OCIM1 cells. In addition, to determine whether the expression of human erythropoietin receptor on endothelial cells occurs in vivo, sections of umbilical cord and placenta were immunostained with antibodies against the extracellular portion of the receptor; the results showed strong positive staining of the vascular endothelium.
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Citations
Cited by
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Erythropoietin receptor signalling is required for normal brain development
Yu, X., Shacka, J. J., Eells, J. B., Suarez-Quian, C., Przygodzki, R. M., Beleslin-Cokic, B., Lin, C.-S., Nikodem, V. M., Hempstead, B., Flanders, K. C., et al. (2002) · Development · doi:10.1242/dev.129.2.505 · Cited by 367
Self-citationThe non‐haematopoietic biological effects of erythropoietin
Arcasoy, M. O. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07014.x · Cited by 347
Wang, L., Zhang, Z. G., Zhang, R. L., Gregg, S. R., Hozeska-Solgot, A., LeTourneau, Y., Wang, Y., & Chopp, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5380-05.2006 · Cited by 316
Erythropoietin regulates tumour growth of human malignancies
Yasuda, Y. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg060 · Cited by 257
Metadata
- Authors
- Anagnostou, A., Liu, Z., Steiner, M., Chin, K., Lee, E. S., Kessimian, N., & Noguchi, C. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-04-26
- Volume
- 91
- Issue
- 9
- Pages
- 3974-3978
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005495277
- Cited by
- 570
- References
- 0
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Anagnostou, A., Liu, Z., Steiner, M., Chin, K., Lee, E. S., Kessimian, N., & Noguchi, C. T. (1994). Erythropoietin receptor mRNA expression in human endothelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.9.3974
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