Cited by 347Erythropoietin and Anemia TreatmentBiosimilars and Bioanalytical MethodsHemoglobin structure and function

The non‐haematopoietic biological effects of erythropoietin

Open access
Arcasoy, Murat O.·2008·British Journal of Haematology

Abstract

Summary: In the haematopoietic system, the principal function of erythropoietin (Epo) is the regulation of red blood cell production, mediated by its specific cell surface receptor (EpoR). Following the cloning of the Epo gene (EPO) and characterization of the selective haematopoietic action of Epo in erythroid lineage cells, recombinant Epo forms (epoetin‐alfa, epoetin‐beta and the long‐acting analogue darbepoetin‐alfa) have been widely used for treatment of anaemia in chronic kidney disease and chemotherapy‐induced anaemia in cancer patients. Ubiquitous EpoR expression in non‐erythroid cells has been associated with the discovery of diverse biological functions for Epo in non‐haematopoietic tissues. During development, Epo–EpoR signalling is required not only for fetal liver erythropoiesis, but also for embryonic angiogenesis and brain development. A series of recent studies suggest that endogenous Epo–EpoR signalling contributes to wound healing responses, physiological and pathological angiogenesis, and the body’s innate response to injury in the brain and heart. Epo and its novel derivatives have emerged as major tissue‐protective cytokines that are being investigated in the first human studies involving neurological and cardiovascular diseases. This review focuses on the scientific evidence documenting the biological effects of Epo in non‐haematopoietic tissues and discusses potential future applications of Epo and its derivatives in the clinic.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1365-2141.2008.07014.x

Cites

206 of 206 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 2

  1. Gruber, M., Hu, C.J., Johnson, R.S., Brown, E.J., Keith, B. & Simon, M.C. (2007) Acute postnatal ablation of Hif-2alpha results in ane- mia. Proceedings of the National Academy of Sciences of the United States of America, 104, 2301-2306.
  2. Shingo, T., Sorokan, S.T., Shimazaki, T. & Weiss, S. (2001) Erythro- poietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. Journal of Neuroscience, 21, 9733-9743.

Authors
Arcasoy, M. O.
Affiliations
Duke Medical Center (US)
Corresponding author
Arcasoy, Murat O.
Venue
British Journal of Haematology
Publisher
Wiley
Published
2008-03-06
Volume
141
Issue
1
Pages
14-31
ISSN
  • 0007-1048 (ISSN-L)
  • 1365-2141
OpenAlex
W2088369648
Cited by
347
References
206
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 15 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 38 · 2012: 28
FWCI
6.51
Type
journal article
Language
en
Open access
Locations
  • British Journal of Haematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense
  • American Heart Association
  • National Institutes of Health (5r21dk065065-02)
  • National Cancer Institute (CA100844, R01CA100844)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK65065)
Topics
  • Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Biosimilars and Bioanalytical Methods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
Keywords
erythropoietin, erythropoietin receptor, epoetin alfa, epoetin beta, darbepoetin alfa, angiogenesis, wound healing, brain development, embryonic development, tissue protection, anemia of chronic kidney disease, chemotherapy-induced anemia, neuroprotection, cardioprotection
MeSH terms
Animals, Cardiotonic Agents, Cardiovascular Physiological Phenomena, Erythropoietin, Humans, Nervous System Physiological Phenomena, Recombinant Proteins, Wound Healing, Signal Transduction, Receptors, Erythropoietin, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review