The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.
Open accessAbstract
Previous studies have implicated the bcl-2 protooncogene as a potential regulator of neuronal survival. However, mice lacking functional bcl-2 exhibited normal development and maintenance of the central nervous system (CNS). Since bcl-2 appears dispensable for neuronal survival, we have examined the expression and function of bcl-x, another member of the bcl-2 family of death regulatory genes. Bcl-2 is expressed in neuronal tissues during embryonic development but is down-regulated in the adult CNS. In contrast, Bcl-xL expression is retained in neurons of the adult CNS. Two different forms of bcl-x mRNA and their corresponding products, Bcl-xL and Bcl-x beta, were expressed in embryonic and adult neurons of the CNS. Microinjection of bcl-xL and bcl-x beta cDNAs into primary sympathetic neurons inhibited their death induced by nerve growth factor withdrawal. Thus, Bcl-x proteins appear to play an important role in the regulation of neuronal survival in the adult CNS.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Apoptosis of Retinal Ganglion Cells in Glaucoma
Nickells, R. W. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00029-6 · Cited by 232
Crossing paths: interactions between the cell death machinery and growth factor survival signals
Brumatti, G., Salmanidis, M., & Ekert, P. G. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0288-8 · Cited by 85
Metadata
- Authors
- González-García, M., García, I., Ding, L., O'Shea, S., Boise, L. H., Thompson, C. B., & Núñez, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-05-09
- Volume
- 92
- Issue
- 10
- Pages
- 4304-4308
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2054669186
- Cited by
- 283
- References
- 2
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- green
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