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Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.
Open accessAbstract
A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.
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Citations
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Metadata
- Authors
- D'Angelo, G., Struman, I., Martial, J., & Weiner, R. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-07-03
- Volume
- 92
- Issue
- 14
- Pages
- 6374-6378
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017520393
- Cited by
- 227
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. https://app.cochat.ai/papers/10.1073/pnas.92.14.6374
- The paper
- D'Angelo, G., Struman, I., Martial, J., & Weiner, R. I. (1995). Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.14.6374
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
