The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy
Open accessAbstract
Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated angiogenesis through downregulation of NRAS. 16K PRL stimulated the release of miR-146a-loaded exosomes from ECs. The exosomes were absorbed by cardiomyocytes, increasing miR-146a levels, which resulted in a subsequent decrease in metabolic activity and decreased expression of Erbb4, Notch1, and Irak1. Mice with cardiomyocyte-restricted Stat3 knockout (CKO mice) exhibited a PPCM-like phenotype and displayed increased cardiac miR-146a expression with coincident downregulation of Erbb4, Nras, Notch1, and Irak1. Blocking miR-146a with locked nucleic acids or antago-miRs attenuated PPCM in CKO mice without interrupting full-length prolactin signaling, as indicated by normal nursing activities. Finally, miR-146a was elevated in the plasma and hearts of PPCM patients, but not in patients with dilated cardiomyopathy. These results demonstrate that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.
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1 retracted
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Circulating microRNAs as stable blood-based markers for cancer detection
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MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice
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Cited by
2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
Self-citationApplication of exosomes as liquid biopsy in clinical diagnosis
Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685
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Self-citationSources and Functions of Extracellular Small RNAs in Human Circulation
Fritz, J. V., Heintz-Buschart, A., Ghosal, A., Wampach, L., Etheridge, A., Galas, D., & Wilmes, P. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050711 · Cited by 121
Qiu, L., Wang, J., Chen, M., Chen, F., & Tu, W. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4634 · Cited by 88
Metadata
- Authors
- Halkein, J., Tabruyn, S. P., Ricke-Hoch, M., Haghikia, A., Nguyen, N.-Q.-N., Scherr, M., Castermans, K., Malvaux, L., Lambert, V., Thiry, M., Sliwa, K., Noel, A., Martial, J. A., Hilfiker-Kleiner, D., & Struman, I.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-04-24
- Volume
- 123
- Issue
- 5
- Pages
- 2143-2154
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2137081126
- Cited by
- 499
- References
- 44
- FWCI
- 25.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Halkein, J., Tabruyn, S. P., Ricke-Hoch, M., Haghikia, A., Nguyen, N.-Q.-N., Scherr, M., Castermans, K., Malvaux, L., Lambert, V., Thiry, M., Sliwa, K., Noel, A., Martial, J. A., Hilfiker-Kleiner, D., & Struman, I. (2013). MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. Journal of Clinical Investigation. https://doi.org/10.1172/jci64365
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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