The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance.
Open accessAbstract
Plants possess multiple resistance mechanisms that guard against pathogen attack. Among these are inducible systems such as systemic acquired resistance (SAR). SAR is activated by pathogen exposure and leads to an increase in salicylic acid (SA), high-level expression of SAR-related genes, and resistance to a spectrum of pathogens. To identify components of the signal transduction pathways regulating SAR, a mutant screen was developed that uses 2,6-dichloroisonicotinic acid as an activator of SAR gene expression and pathogen resistance, followed by assays for resistance to the fungal pathogen Peronospora parasitica. Mutants from this screen were subsequently examined to assess their defense responses. We describe here a recessive mutation that causes a phenotype of insensitivity to chemical and biological inducers of SAR genes and resistance. These data indicate the existence of a common signaling pathway that couples these diverse stimuli to induction of SAR genes and resistance. Because of its non-inducible immunity phenotype, we call this mutant nim1. Although nim1 plants fail to respond to SA, they retain the ability to accumulate wild-type levels of SA, a probable endogenous signal for SAR. Further, the ability of nim1 plants to support growth of normally incompatible races of a fungal pathogen indicates a role for this pathway in expression of genetically determined resistance, consistent with earlier findings for transgenic plants engineered to break down SA. These results suggest that the wild-type NIM1 gene product functions in a pathway regulating acquired resistance, at a position downstream of SA accumulation and upstream of SAR gene induction and expression of resistance.
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Cites
Requirement of Salicylic Acid for the Induction of Systemic Acquired Resistance
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Self-citationA Central Role of Salicylic Acid in Plant Disease Resistance
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Self-citationTransgenic Plants with Enhanced Resistance to the Fungal Pathogen Rhizoctonia solani
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Self-citationArabidopsis mutants simulating disease resistance response
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Cited by
Durrant, W. E., & Dong, X. (2004) · Annual Review of Phytopathology · doi:10.1146/annurev.phyto.42.040803.140421 · Cited by 3,184
SYSTEMIC RESISTANCE INDUCED BY RHIZOSPHERE BACTERIA
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Isochorismate synthase is required to synthesize salicylic acid for plant defence
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Resistance gene-dependent plant defense responses.
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Metadata
- Authors
- Delaney, T. P., Friedrich, L., & Ryals, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-07-03
- Volume
- 92
- Issue
- 14
- Pages
- 6602-6606
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023183725
- Cited by
- 772
- References
- 12
- FWCI
- 34.82
- Type
- journal article
- Language
- en
- Open access
- green
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