Cited by 3,184Plant-Microbe Interactions and ImmunityInsect-Plant Interactions and ControlImmune Response and Inflammation

SYSTEMIC ACQUIRED RESISTANCE

Durrant, W.E., Dong, X.·2004·Annual Review of Phytopathology

Abstract

▪ Abstract Systemic acquired resistance (SAR) is a mechanism of induced defense that confers long-lasting protection against a broad spectrum of microorganisms. SAR requires the signal molecule salicylic acid (SA) and is associated with accumulation of pathogenesis-related proteins, which are thought to contribute to resistance. Much progress has been made recently in elucidating the mechanism of SAR. Using the model plant Arabidopsis, it was discovered that the isochorismate pathway is the major source of SA during SAR. In response to SA, the positive regulator protein NPR1 moves to the nucleus where it interacts with TGA transcription factors to induce defense gene expression, thus activating SAR. Exciting new data suggest that the mobile signal for SAR might be a lipid molecule. We discuss the molecular and genetic data that have contributed to our understanding of SAR and present a model describing the sequence of events leading from initial infection to the induction of defense genes.

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Crossref · 10.1146/annurev.phyto.42.040803.140421

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Authors
Durrant, W. E., & Dong, X.
Affiliations
Duke University (US)
Venue
Annual Review of Phytopathology
Published
2004-09-01
Volume
42
Issue
1
Pages
185-209
ISSN
  • 0066-4286 (ISSN-L)
  • 1545-2107
OpenAlex
W2129742189
Cited by
3,184
References
130
Citations by year
2026: 81 · 2025: 124 · 2024: 102 · 2023: 137 · 2022: 131 · 2021: 171 · 2020: 176 · 2019: 132 · 2018: 113 · 2017: 161 · 2016: 134 · 2015: 177 · 2014: 207 · 2013: 217 · 2012: 186
FWCI
8.74
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Phytopathology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • U.S. Department of Agriculture
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
systemic acquired resistance, salicylic acid, NPR1, TGA transcription factors, pathogenesis-related proteins, induced plant defense, defense gene expression, lipid signaling, Arabidopsis thaliana, plant immunity
MeSH terms
DNA-Binding Proteins, Immunity, Innate, Nuclear Proteins, Transcription Factors, Signal Transduction, Arabidopsis, Models, Immunological, Gene Expression Regulation, Plant, Salicylic Acid, Arabidopsis Proteins

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