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Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription.
Open accessAbstract
NGFI-A (also called Egr1, Zif268, or Krox24) and the closely related proteins Krox20, NGFI-C, and Egr3 are zinc-finger transcription factors encoded by immediate-early genes which are induced by a wide variety of extracellular stimuli. NGFI-A has been implicated in cell proliferation, macrophage differentiation, synaptic activation, and long-term potentiation, whereas Krox20 is critical for proper hindbrain segmentation and peripheral nerve myelination. In previous work, a structure/function analysis of NGFI-A revealed a 34-aa inhibitory domain that was hypothesized to be the target of a cellular factor that represses NGFI-A transcriptional activity. Using the yeast two-hybrid system, we have isolated a cDNA clone which encodes a protein that interacts with this inhibitory domain and inhibits the ability of NGFI-A to activate transcription. This NGFI-A-binding protein, NAB1, is a 570-aa nuclear protein that bears no obvious sequence homology to known proteins. NAB1 also represses Krox20 activity, but it does not influence Egr3 or NGFI-G, thus providing a mechanism for the differential regulation of this family of immediate-early transcription factors.
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A. (1993) · Cell · doi:10.1016/0092-8674(93)90660-i · Cited by 367
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Clayton, D. F. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2000.3967 · Cited by 322
Chapter 8 Hox Genes and Segmentation of the Vertebrate Hindbrain
Tümpel, S., Wiedemann, L. M., & Krumlauf, R. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88004-6 · Cited by 150
Metadata
- Authors
- Russo, M. W., Sevetson, B. R., & Milbrandt, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-07-18
- Volume
- 92
- Issue
- 15
- Pages
- 6873-6877
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006345574
- Cited by
- 267
- References
- 2
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Russo, M. W., Sevetson, B. R., & Milbrandt, J. (1995). Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.15.6873
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