The DOI matches its Crossref record.
Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.
Open accessAbstract
Homozygous mice mutated by homologous recombination for the AbdB-related Hoxa-10 gene are viable but display homeotic transformations of vertebrae and lumbar spinal nerves. Mutant males exhibit unilateral or bilateral criptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and sterility. These results reveal an important role of Hoxa-10 in patterning posterior body regions and suggest that Hox genes are involved in specifying regional identity of both segmented and nonovertly segmented structures of the developing body.
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Citations
Cited by
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Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
Role of Endocytosis in Cellular Uptake of Sex Steroids
Hammes, A., Andreassen, T. K., Spoelgen, R., Raila, J., Hubner, N., Schulz, H., Metzger, J., Schweigert, F. J., Luppa, P. B., Nykjaer, A., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.032 · Cited by 413
Lim, H. J., Ma, L., Ma, W., Maas, R. L., & Dey, S. K. (1999) · Molecular Endocrinology · doi:10.1210/me.13.6.1005 · Cited by 326
Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Dollé, P., & Chambon, P. (1996) · Development · doi:10.1242/dev.122.2.461 · Cited by 266
Self-citationPARALOGOUS HOX GENES: Function and Regulation
Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.529 · Cited by 220
Metadata
- Authors
- Rijli, F. M., Matyas, R., Pellegrini, M., Dierich, A., Gruss, P., Dollé, P., & Chambon, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-08-29
- Volume
- 92
- Issue
- 18
- Pages
- 8185-8189
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978380475
- Cited by
- 162
- References
- 0
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Rijli, F. M., Matyas, R., Pellegrini, M., Dierich, A., Gruss, P., Dollé, P., & Chambon, P. (1995). Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.18.8185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
