Cited by 308Telomeres, Telomerase, and SenescenceCancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

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Increased activity of p53 in senescing fibroblasts

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Atadja, P, Wong, H, Garkavtsev, I, Veillette, C, Riabowol, K·1995·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.92.18.8348PMC PMC41154

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Abstract

The p53 tumor-suppressor protein binds DNA and activates the expression of a 21-kDa protein that inhibits both the activity of cyclin-dependent kinases and the function of proliferating cell nuclear antigen. Since p21 expression has been reported to increase 10- to 20-fold as human diploid fibroblasts lose the ability to replicate, we examined the expression and activity of p53 during replicative aging. Similar levels of total p53 mRNA and protein were expressed in low-passage (young) and high-passage (old) cells but both DNA binding activity in vitro and transcriptional activity of p53 in vivo were increased severalfold in high-passage cells. While the basis of increased p53 activity is presently unclear, it is not correlated with differential phosphorylation or changes in p53-mouse double minute 2 gene product interactions. These results provide evidence for the activation of a protein involved in the control of cell cycle checkpoints during cellular aging, in the absence of increased expression.

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WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., & Smith, J. R. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1063 · Cited by 1,351
Identification of p53 as a Sequence-Specific DNA-Binding Protein
Kern, S. E., Kinzler, K. W., Bruskin, A. M., Jarosz, D., Friedman, P. N., Prives, C. L., & Vogelstein, B. (1991) · Science · doi:10.1126/science.2047879 · Cited by 1,085
Monoclonal antibodies specific for simian virus 40 tumor antigens
Harlow, E., Crawford, L. V., Pim, D. C., & Williamson, N. M. (1981) · Journal of Virology · doi:10.1128/jvi.39.3.861-869.1981 · Cited by 1,038

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Inactivation of p53 and life span extension of human diploid fibroblasts by mot‐2
Kaul, S. C., Reddel, R. R., Sugihara, T., Mitsui, Y., & Wadhwa, R. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01594-5 · Cited by 76
Similar Gene Expression Pattern in Senescent and Hyperoxic-Treated Fibroblasts
Saretzki, G. C., Feng, J., von Zglinicki, T., & Villeponteau, B. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.6.b438 · Cited by 76
Cellular Senescence: Ex Vivo p53‐Dependent Asymmetric Cell Kinetics
Rambhatla, L., Bohn, S. A., Stadler, P. B., Boyd, J. T., Coss, R. A., & Sherley, J. L. (2001) · BioMed Research International · doi:10.1155/s1110724301000079 · Cited by 74
Replicative Senescence Induced by Romo1-derived Reactive Oxygen Species
Chung, Y. M., Lee, S. B., Kim, H. J., Park, S. H., Kim, J. J., Chung, J. S., & Yoo, Y. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805334200 · Cited by 73
Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase
de Magalhães, J. P., Debacq‐Chainiaux, F., de Longueville, F., Mainfroid, V., Migeot, V., Marcq, L., Remacle, J., Salmon, M., & Toussaint, O. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.004 · Cited by 76
The Regulation of Cellular Functions by the p53 Protein: Cellular SenescencePreprint
Tonnessen-Murray, C. A., Lozano, G., & Jackson, J. G. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026112 · Cited by 76
Impaired Odontogenic Differentiation of Senescent Dental Mesenchymal Stem Cells Is Associated with Loss of Bmi-1 Expression
Mehrazarin, S., Oh, J. E., Chung, C. L., Chen, W., Kim, R. H., Shi, S., Park, N.-H., & Kang, M. (2011) · Journal of Endodontics · doi:10.1016/j.joen.2011.02.009 · Cited by 68
The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis
Yonish-Rouach, E. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01920109 · Cited by 68
A reassessment of the telomere hypothesis of senescence
Reddel, R. R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199812)20:12 · Cited by 65
Expression Profiles of p53-, p16INK4a-, and Telomere-Regulating Genes in Replicative Senescent Primary Human, Mouse, and Chicken Fibroblast Cells
Kim, H., You, S., Farris, J., Kong, B. C., Christman, S. A., Foster, L. K., & Foster, D. N. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5420 · Cited by 65
Loss of functional caveolae during senescence of human fibroblasts
Wheaton, K., Sampsel, K., Boisvert, F., Davy, A., Robbins, S. M., & Riabowol, K. T. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1071 · Cited by 61
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POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway
Cho, J. H., Kim, M. J., Kim, K. J., & Kim, J.-R. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.142 · Cited by 59
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ING1 isoforms differentially affect apoptosis in a cell age-dependent manner.
Vieyra, D. S., Toyama, T., Hara, Y., Boland, D., Johnston, R. N., & Riabowol, K. T. (2002) · PubMed · Cited by 57
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Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-37 · Cited by 57
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Soliman, M. A., Berardi, P., Pastyryeva, S., Bonnefin, P., Feng, X., Colina, A. R., Young, D., & Riabowol, K. T. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00427.x · Cited by 60
Self-citation
Molecular biology of prostate cancer
Karayi, M. K., & MARKHAM, A. F. (2004) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500697 · Cited by 57
Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53
Chaturvedi, V., Qin, J.-Z., Stennett, L. S., Choubey, D., & Nickoloff, B. J. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10392 · Cited by 57
Accelerated Development and Aging of the Immune System in p53-Deficient Mice
Ohkusu‐Tsukada, K., Tsukada, T., & Isobe, K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1966 · Cited by 56
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Kong, Y., Cui, H., Ramkumar, C., & Zhang, H. (2011) · Journal of Aging Research · doi:10.4061/2011/963172 · Cited by 61
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Zmijewski, J. W., & Jope, R. S. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00117.x · Cited by 54
Inactivation of p16 INK4a (inhibitor of cyclin‐dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment
Maurelli, R., Zambruno, G., Guerra, L., Abbruzzese, C., Dimri, G. P., Gellini, M., Bondanza, S., & Dellambra, E. (2006) · The FASEB Journal · doi:10.1096/fj.05-4480fje · Cited by 54
Nucleotide excision repair gene (ERCC1) deficiency causes G 2 arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21
Núñez, F., Chipchase, M. D., Clarke, A. R., & Melton, D. W. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1073 · Cited by 56
SV40-Mediated Immortalization
Ozer, H. L. (1999) · Progress in molecular and subcellular biology · doi:10.1007/978-3-662-06227-2_6 · Cited by 54
Models of initiation of replicative senescence by loss of telomeric DNA
Allsopp, R. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(95)02008-x · Cited by 54
MicroRNAs in human skin ageing
Mancini, M., Lena, A. M., Saintigny, G., Mahé, C., Daniele, N. D., Melino, G., & Candi, E. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.04.003 · Cited by 53
Murine Models of Life Span Extension
Quarrie, J. K., & Riabowol, K. T. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.31.re5 · Cited by 53
Self-citation
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Nakamura, S., & Nishioka, K. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05589.x · Cited by 50
MMP-9 Short Interfering RNA Induced Senescence Resulting in Inhibition of Medulloblastoma Growth via p16INK4a and Mitogen-Activated Protein Kinase Pathway
Rao, J. S., Bhoopathi, P., Chetty, C., Gujrati, M., & Lakka, S. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0380 · Cited by 50
Induction of Cellular Senescence by Secretory Phospholipase A2 in Human Dermal Fibroblasts through an ROS-Mediated p53 Pathway
Kim, H. J., Kim, K. S., Kim, S. H., Baek, S.-H., Kim, H. Y., Lee, C., & Kim, J. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln055 · Cited by 50
Regulation of p53 during senescence in normal human keratinocytes
Kim, R. H., Kang, M., Kim, T., Yang, P., Bae, S., Williams, D. W., Phung, S., Shin, K., Hong, C., & Park, N. (2015) · Aging Cell · doi:10.1111/acel.12364 · Cited by 49
A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblasts
Sidler, C. L., Wóycicki, R. K., Li, D., Wang, B., Kovalchuk, I., & Kovalchuk, O. (2014) · Aging · doi:10.18632/aging.100678 · Cited by 51
Telomeres: Influencing the Rate of Aging
von Zglinicki, T. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09912.x · Cited by 48
Macrophage Migration Inhibitory Factor Regulates AKT Signaling in Hypoxic Culture to Modulate Senescence of Human Mesenchymal Stem Cells
Palumbo, S. L., Tsai, T.-L., & Li, W. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0294 · Cited by 48
Proliferative lifespan checkpoints: Cell-type specificity and influence on tumour biology
Wynford‐Thomas, D. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00064-6 · Cited by 48
In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes
Kirsch, V., Ramge, J.-M., Schoppa, A., Ignatius, A., & Riegger, J. (2022) · Cells · doi:10.3390/cells11071106 · Cited by 47
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Alspach, E., Fu, Y., & Stewart, S. A. (2013) · Critical Reviews in Oncogenesis · doi:10.1615/critrevoncog.2014010630 · Cited by 47
Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells
Moh, M. C., Zhang, T., Lee, L. H., & Shen, S. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn226 · Cited by 48
Repeated exposure of mouse dermal fibroblasts at a sub-cytotoxic dose of UVB leads to premature senescence: A robust model of cellular photoaging
Zeng, J.-P., Bi, B., Chen, L., Yang, P. C., Guo, Y., Zhou, Y.-Q., & Liu, T. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.08.013 · Cited by 50
HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
McDermott, M. S. J., Conlon, N. T., Browne, B. C., Szabo, A., Synnott, N. C., O’Brien, N. A., Duffy, M. J., Crown, J. P., & O’Donovan, N. (2019) · Cancers · doi:10.3390/cancers11020197 · Cited by 45
BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence
Wheaton, K., Muir, J., Ma, W., & Benchimol, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00601.x · Cited by 46
Telomeres and Telomerase Biology in Vertebrates: Progress Towards a Non-Human Model for Replicative Senescence and Ageing
Davis, T., & Kipling, D. (2005) · Biogerontology · doi:10.1007/s10522-005-4901-4 · Cited by 46
Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts
Favetta, L. A., Robert, C., King, W. A., & Betts, D. H. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.05.009 · Cited by 45
Age‐dependent atrophy and microgravity travel: what do they have in common?
Wang, E. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9001.s167 · Cited by 46
Transcriptional regulation of cellular ageing by the CCAAT box-binding factor CBF/NF-Y
Matuoka, K. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00026-0 · Cited by 46
Senescence and immortalization of human cells
Duncan, E. L., Wadhwa, R., & Kaul, S. C. (2000) · Biogerontology · doi:10.1023/a:1010000132671 · Cited by 46
Centriolar Mechanisms of Differentiation and Replicative Aging of Higher Animal Cells
Tkemaladze, J., & Chichinadze, K. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0261-6 · Cited by 47
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Ruhland, M. K., & Alspach, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.754069 · Cited by 45
Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines
Holmes, W. F., Soprano, D. R., & Soprano, K. J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.10338 · Cited by 43
Genes Involved in the Control of Cellular Proliferative Potentiala
Reddel, R. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09887.x · Cited by 44
A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts
Manning, J. A., & Kumar, S. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.12 · Cited by 41
Expression of Senescence-Associated microRNAs and Target Genes in Cellular Aging and Modulation by Tocotrienol-Rich Fraction
Khee, S. G. S., Yusof, Y. A. M., & Makpol, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/725929 · Cited by 41
Evolutionarily conserved transcription factors as regulators of longevity and targets for geroprotection
Fischer, F., Grigolon, G., Benner, C., & Ristow, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00017.2021 · Cited by 42
Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines.
Isaacs, J., Hardman, R. C., Carman, T. A., Barrett, J. C., & Weissman, B. E. (1998) · PubMed · Cited by 39
The Genetics of Cellular Senescence
Bérubé, N. G., Smith, J. R., & Pereira‐Smith, O. M. (1998) · The American Journal of Human Genetics · doi:10.1086/301848 · Cited by 39
Fullerene derivatives induce premature senescence: A new toxicity paradigm or novel biomedical applications
Gao, J., Wang, H. L., Shreve, A. P., & Iyer, R. S. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.12.025 · Cited by 40
Establishment of a Novel Chondrocytic Cell Line N1511 Derived From p53-Null Mice
Kamiya, N., Jikko, A., Kimata, K., Damsky, C. H., Shimizu, K., & Watanabe, H. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.10.1832 · Cited by 38
Alterations in p53 and E2F-1 function common to immortalized chicken embryo fibroblasts
Kim, H., You, S., Kim, I.-J., Foster, L. K., Farris, J., Ambady, S., de León, F. A. P., & Foster, D. N. (2001) · Oncogene · doi:10.1038/sj.onc.1204378 · Cited by 38
SIPS as a model to study age-related changes in proteolysis and aggregate formation
Ott, C., Jung, T., Grune, T., & Höhn, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.007 · Cited by 40
Telomere uncapping during in vitro T‐lymphocyte senescence
Chebel, A., Bauwens, S., Gerland, L., Belleville, A., Urbanowicz, I., de Climens, A. R., Tourneur, Y., Chien, W. W., Catallo, R., Salles, G. A., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00448.x · Cited by 39
The ING1a Tumor Suppressor Regulates Endocytosis to Induce Cellular Senescence Via the Rb-E2F Pathway
Rajarajacholan, U. K., Thalappilly, S., & Riabowol, K. T. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001502 · Cited by 42
Self-citation
The Impact of Long-Term In Vitro Expansion on the Senescence-Associated Markers of Human Adipose-Derived Stem Cells
Zaman, W. S. W. K., Makpol, S., Sathapan, S., & Chua, K. H. (2012) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9637-4 · Cited by 38
Regulation of transcription factor activity during cellular aging
Wheaton, K., Atadja, P. W., & Riabowol, K. T. (1996) · Biochemistry and Cell Biology · doi:10.1139/o96-056 · Cited by 36
Self-citation
The genetic basis of human keratinocyte immortalisation in squatnous cell carcinoma development: The role of telomerase reactivation
Parkinson, E. K., Newbold, R. F., & Keith, W. N. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00063-4 · Cited by 38
Cellular senescence and neurodegeneration
Holloway, K., Neherin, K., Dam, K. U., & Zhang, H. (2023) · Human Genetics · doi:10.1007/s00439-023-02565-x · Cited by 40
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TGF-β signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: Role of the β-spectrin, ELF
Kim, S. S., Shetty, K., Katuri, V., Kitisin, K., Baek, H. J., Tang, Y., Marshall, B., Johnson, L. B., Mishra, B., & Mishra, L. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.236 · Cited by 34
Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein
Węsierska‐Gądek, J., & Schmid, G. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.1.23 · Cited by 34
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Khan, S., Chib, R., Shah, B. A., Wani, Z. A., Dhar, N., Mondhe, D. M., Lattoo, S. K., Jain, S. K., Taneja, S. C., & Singh, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.013 · Cited by 33
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Wen, Y., Wani, P., Zhou, L., Baer, T., Phadnis, S. M., Pera, R. A. R., & Chen, B. H. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2012-0092 · Cited by 32
Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen
Conzen, S. D., Snay, C. A., & Cole, C. N. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4536-4543.1997 · Cited by 32
The membrane hypothesis of aging: its relevance to recent progress in genetic research
Zs.-Nagy, I. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050157 · Cited by 31
Benign tumors of the breast with multinucleated stromal giant cells
Ryška, A., Reynolds, C. A., & Keeney, G. L. (2001) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280100470 · Cited by 30
Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals
Pizzute, T., Li, J., Zhang, Y., Davis, M. E., & Pei, M. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0102 · Cited by 29
Molecular Aspects of the Relationship between Cancer and Aging: Tumor Suppressor Activity During Cellular Senescence
Garkavtsev, I., Hull, C. M., & Riabowol, K. T. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00086-7 · Cited by 29
Self-citation
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Liu, K., Jin, B., Wu, C., Yang, J., Zhan, X., Wang, L., Shen, X., Chen, J., Chen, H., & Mao, Z. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11978 · Cited by 28
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Jiang, D., Sun, W., Wu, T., Zou, M., Vasamsetti, S. B., Zhang, X., Zhao, Y., Phillippi, J. A., Sawalha, A. H., Tavakoli, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00177-0 · Cited by 29
Cellular senescence induced by cathepsin X downregulation
Kraus, S., Bunsen, T., Schuster, S., Cichoń, M. A., Tacke, M., Reinheckel, T., Sommerhoff, C. P., Jochum, M., & Nägler, D. K. (2011) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.03.008 · Cited by 29
Alternative product of the p16/CKDN2A locus connects the Rb and p53 tumor suppressors
James, M. C., & Peters, G. G. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4253-7_7 · Cited by 27
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates
Schwenger, P., Alpert, D. R., Skolnik, E. Y., & ek, J. V. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199904)179:1 · Cited by 55
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Self-citation

Authors: Atadja, P., Wong, H., Garkavtsev, I., Veillette, C., & Riabowol, K.
Affiliations: University of Calgary (CA)
ORCID: Wong, H
Veillette, C
Riabowol, K
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1995-08-29
Volume: 92
Issue: 18
Pages: 8348-8352
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.92.18.8348
PMC: PMC41154
OpenAlex: W1996966832
Cited by: 308
References: 51
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 13 · 2013: 9 · 2012: 7
FWCI: 9.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council Canada
Medical Research Council
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: p53, replicative senescence, fibroblasts, p21, tumor suppressor proteins, DNA-binding activity, transcriptional activation, cell cycle checkpoints, cellular aging, cyclin-dependent kinases, proliferating cell nuclear antigen, p53 phosphorylation, MDM2
MeSH terms: Adult, Base Sequence, Binding Sites, Cell Line, DNA, Fibroblasts, Glyceraldehyde-3-Phosphate Dehydrogenases, Humans, Molecular Sequence Data, Nuclear Proteins, Oligodeoxyribonucleotides, Phosphorylation, Proto-Oncogene Proteins, RNA, Messenger, Tumor Suppressor Protein p53, Cellular Senescence, Proto-Oncogene Proteins c-mdm2

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Increased activity of p53 in senescing fibroblasts

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