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The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.
Open accessAbstract
p53 accumulates after DNA damage and arrests cellular growth. These findings suggest a possible role for p53 in the cellular response to DNA damage. We have previously shown that the C terminus of p53 binds DNA nonspecifically and assembles stable tetramers. In this study, we have utilized purified segments of human and murine p53s to determine which p53 domains may participate in a DNA damage response pathway. We find that the C-terminal 75 amino acids of human or murine p53 are necessary and sufficient for the DNA annealing and strand-transfer activities of p53. In addition, both full-length wild-type p53 and the C-terminal 75 amino acids display an increased binding affinity for DNA damaged by restriction digestion, DNase I treatment, or ionizing radiation. In contrast, the central site-specific DNA-binding domain together with the tetramerization domain does not have these activities. We propose that interactions of the C terminus of p53 with damaged DNA may play a role in the activation of p53 in response to DNA damage.
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Cites
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Cited by
Shieh, S.-Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1815 · Cited by 300
p53 in recombination and repair
Gatz, S. A., & Wiesmüller, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401903 · Cited by 242
Ambs, S., Hussain, S. P., & Harris, C. C. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.6.9194524 · Cited by 233
Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look
Soussi, T., & May, P. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0425 · Cited by 208
Cuddihy, A. R., Hoi-Tao Wong, A., Wai Ning Tam, N., Li, S., & Koromilas, A. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202620 · Cited by 203
Metadata
- Authors
- Reed, M., Woelker, B., Wang, P., Wang, Y., Anderson, M. E., & Tegtmeyer, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-10-10
- Volume
- 92
- Issue
- 21
- Pages
- 9455-9459
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2006607764
- Cited by
- 187
- References
- 1
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Reed, M., Woelker, B., Wang, P., Wang, Y., Anderson, M. E., & Tegtmeyer, P. (1995). The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.21.9455
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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