p53 in recombination and repair

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113 · see citing works

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., & Tlsty, T. D. (1992) · Cell · doi:10.1016/0092-8674(92)90243-6 · Cited by 1,333 · see citing works

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

Komarov, P. G., Komarova, E. A., Kondratov, R. V., Christov-Tselkov, K., Coon, J. S., Chernov, M. V., & Gudkov, A. V. (1999) · Science · doi:10.1126/science.285.5434.1733 · Cited by 1,270 · see citing works

Pathways of DNA Double-Strand Break Repair during the Mammalian Cell Cycle

Rothkamm, K., Krüger, I., Thompson, L. H., & Lübrich, M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5706-5715.2003 · Cited by 1,187 · see citing works

Identification of p53 as a Sequence-Specific DNA-Binding Protein

Kern, S. E., Kinzler, K. W., Bruskin, A. M., Jarosz, D., Friedman, P. N., Prives, C. L., & Vogelstein, B. (1991) · Science · doi:10.1126/science.2047879 · Cited by 1,085 · see citing works

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C.-Y., Gilmer, T. M., Kastan, M. B., O'Connor, P. M., & Fornace, A. J. (1994) · Science · doi:10.1126/science.7973727 · Cited by 946 · see citing works

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Tanaka, H., Arakawa, H., Yamaguchi, T., Shiraishi, K., Fukuda, S., Matsui, K., Takei, Y., & Nakamura, Y. (2000) · Nature · doi:10.1038/35003506 · Cited by 904 · see citing works

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C. M., Recio, M.-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.029 · Cited by 837 · see citing works

Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753 · see citing works

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint

Zhao, J., Kennedy, B. K., Lawrence, B. D., Barbie, D. A., Matera, A. G., Fletcher, J. A., & Harlow, E. (2000) · Genes & Development · doi:10.1101/gad.827700 · Cited by 665 · see citing works

Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 631 · see citing works

Expression of the <i>p48</i> xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

Hwang, B. J., Ford, J. M., Hanawalt, P. C., & Chu, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.424 · Cited by 581 · see citing works

TP53 tumor suppressor gene: A model for investigating human mutagenesis

de Fromentel, C. C., & Soussi, T. (1992) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870040102 · Cited by 579 · see citing works

Regulation and mechanisms of mammalian double-strand break repair

Valerie, K. C., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 572 · see citing works

p53 modulation of TFIIH–associated nucleotide excision repair activity

Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., et al. (1995) · Nature Genetics · doi:10.1038/ng0695-188 · Cited by 550 · see citing works

p53: traffic cop at the crossroads of DNA repair and recombination

Sengupta, S., & Harris, C. C. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1546 · Cited by 544 · see citing works

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

Stark, J. M., Pierce, A. J., Oh, J., Pastink, A., & Jasin, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.21.9305-9316.2004 · Cited by 501 · see citing works

BRCA1 physically associates with p53 and stimulates its transcriptional activity

Zhang, H., Somasundaram, K., Peng, Y., Tian, H., Zhang, H., Bi, D., Weber, B. L., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201932 · Cited by 492 · see citing works

Dissecting p53 tumor suppressor functions in vivo

Schmitt, C. A., Fridman, J. S., Yang, M., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00047-8 · Cited by 481 · see citing works

Identification of redox/repair protein Ref-1 as a potent activator of p53.Preprint

Jayaraman, L., Murthy, K. G. K., Zhu, C., Curran, T., Xanthoudakis, S., & Prives, C. L. (1997) · Genes & Development · doi:10.1101/gad.11.5.558 · Cited by 479 · see citing works

Untitled work

(1993) · PubMed · Cited by 469 · see citing works

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

Smith, M. L., Ford, J. M., Hollander, M. C., Bortnick, R. A., Amundson, S. A., Seo, Y. R., Deng, C., Hanawalt, P. C., & Fornace, A. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3705-3714.2000 · Cited by 432 · see citing works

Recombinational DNA repair and human disease

Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417 · see citing works

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

Lee, S., Elenbaas, B., Levine, A. J., & Griffith, J. D. (1995) · Cell · doi:10.1016/s0092-8674(05)80006-6 · Cited by 405 · see citing works

Mismatch repair and DNA damage signalling

Stojic, L., Brun, R., & Jiricny, J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.006 · Cited by 396 · see citing works

ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

Vaziri, H., West, M. D., Allsopp, R., Davison, T. S., Wu, Y., Arrowsmith, C. H., Poirier, G. G., & Benchimol, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.6018 · Cited by 384 · see citing works

Chemistry and Biology of DNA Repair

Schärer, O. D. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200523 · Cited by 381 · see citing works

BRCA1 regulates p53-dependent gene expression

Ouchi, T., Monteiro, Á. N. A., August, A., Aaronson, S. A., & Hanafusa, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2302 · Cited by 375 · see citing works

RecQ helicases: suppressors of tumorigenesis and premature aging

Bachrati, C. Z., & Hickson, I. D. (2003) · Biochemical Journal · doi:10.1042/bj20030491 · Cited by 372 · see citing works

Repair of DNA double strand breaks by non-homologous end joining

Lees‐Miller, S. P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.011 · Cited by 367 · see citing works

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

Smith, M. L., Chen, I. T., Zhan, Q., O'Connor, P. M., & Fornace, A. J. (1995) · PubMed · Cited by 364 · see citing works

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 356 · see citing works

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

Ford, J. M., & Hanawalt, P. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8876 · Cited by 343 · see citing works

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

Jayaraman, L., & Prives, C. L. (1995) · Cell · doi:10.1016/s0092-8674(05)80007-8 · Cited by 343 · see citing works

The cellular response to DNA double-strand breaks: defining the sensors and mediators

Petrini, J. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00170-3 · Cited by 339 · see citing works

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

Stürzbecher, H.-W., Donzelmann, B., Henning, W., Knippschild, U., & Buchhop, S. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00550.x · Cited by 338 · see citing works

Characterization of homologous recombination induced by replication inhibition in mammalian cells

Saintigny, Y., Delacôte, F., Varès, G., Petitot, F., Lambert, S., Averbeck, D., & López, B. S. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3861 · Cited by 334 · see citing works

A role for p53 in base excision repair

Zhou, J., Ahn, J., Wilson, S. H., & Prives, C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.4.914 · Cited by 333 · see citing works

The p53 response to DNA damage

Meek, D. W. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.03.027 · Cited by 329 · see citing works

p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

Adimoolam, S., & Ford, J. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202485699 · Cited by 321 · see citing works

Replication fork pausing and recombination or “gimme a break”Preprint

Rothstein, R. J., Michel, B., & Gangloff, S. (2000) · Genes & Development · doi:10.1101/gad.14.1.1 · Cited by 320 · see citing works

Mismatch repair defects in cancer

Jiricny, J., & Nyström, M. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00066-6 · Cited by 293 · see citing works

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

Bakalkin, G. Y., Yakovleva, T., Selivanova, G., Magnússon, K. P., Székely, L., Владимировна, К. Е., Klein, G., Terenius, L. Y., & Wiman, K. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.413 · Cited by 274 · see citing works

The BRCA 2 gene product functionally interacts with p53 and RAD51

Marmorstein, L. Y., Ouchi, T., & Aaronson, S. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13869 · Cited by 268 · see citing works

DNA mismatch repair and mutation avoidance pathways

Marti, T. M., Kunz, C., & Fleck, O. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10077 · Cited by 253 · see citing works

Phosphorylation Site Interdependence of Human p53 Post-translational Modifications in Response to Stress

Saito, S., Yamaguchi, H., Higashimoto, Y., Chao, C., Xu, Y., Fornace, A. J., Appella, E., & Anderson, C. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305135200 · Cited by 253 · see citing works

Alterations in p53 and p16 INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

Rogan, E. M., Bryan, T. M., Hukku, B., Maclean, K. N., Chang, A. C.-M., Moy, E. L., Englezou, A., Warneford, S., Dalla‐Pozza, L., & Reddel, R. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4745 · Cited by 250 · see citing works

p53 Protein Exhibits 3′-to-5′ Exonuclease Activity

Mummenbrauer, T., Janus, F., Müller, B., Wiesmüller, L., Deppert, W., & Große, F. (1996) · Cell · doi:10.1016/s0092-8674(00)81309-4 · Cited by 249 · see citing works

Ref‐1 regulates the transactivation and pro‐apoptotic functions of p53 in vivo

Gaiddon, C., Moorthy, N. C., & Prives, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5609 · Cited by 244 · see citing works

Transcription — guarding the genome by sensing DNA damage

Ljungman, M. E., & Lane, D. P. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1435 · Cited by 233 · see citing works

p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage

Rubbi, C. P., & Milner, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg082 · Cited by 229 · see citing works

Inactivation of p53 results in high rates of homologous recombination

Mekeel, K. L., Tang, W., Kachnic, L. A., Luo, C., DeFrank, J. S., & Powell, S. N. (1997) · Oncogene · doi:10.1038/sj.onc.1201143 · Cited by 223 · see citing works

p53‐catalyzed annealing of complementary single‐stranded nucleic acids.

Oberosler, P., Hloch, P., Ramsperger, U., & Stahl, H. D. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05893.x · Cited by 222 · see citing works

Interaction of p53 with the Human Rad51 Protein

Buchhop, S., Gibson, M. K., Wang, X. W., Wagner, P., Stürzbecher, H.-W., & Harris, C. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.19.3868 · Cited by 212 · see citing works

BLM helicase‐dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

Sengupta, S., Linke, S. P., Pedeux, R., Yang, Q., Farnsworth, J., Garfield, S. H., Valerie, K. C., Shay, J. W., Ellis, N. A., Wasylyk, B., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg114 · Cited by 210 · see citing works

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

Reed, M. J., Woelker, B., Wang, P., Wang, Y., Anderson, M. E., & Tegtmeyer, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9455 · Cited by 187 · see citing works

Base Excision Repair Intermediates Induce p53-independent Cytotoxic and Genotoxic Responses

Sobol, R. W., Kartalou, M., Almeida, K. H., Joyce-Gray, D. F., Engelward, B. P., Horton, J. K., Prasad, R., Samson, L. D., & Wilson, S. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306592200 · Cited by 183 · see citing works

p53 and regulation of DNA damage recognition during nucleotide excision repair

Adimoolam, S., & Ford, J. M. (2003) · DNA Repair · doi:10.1016/s1568-7864(03)00087-9 · Cited by 181 · see citing works

Physical and Functional Interaction between p53 and the Werner's Syndrome Protein

Blander, G., Kipnis, J., Martínez-Leal, J. F., Yu, C., Schellenberg, G. D., & Oren, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29463 · Cited by 181 · see citing works

From the Cover: p53 accumulates but is functionally impaired when DNA synthesis is blocked

Gottifredi, V., Shieh, S.-Y., Taya, Y., & Prives, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.021282898 · Cited by 181 · see citing works

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53

Albrechtsen, N., Dornreiter, I., Große, F., Kim, E. L., Wiesmüller, L., & Deppert, W. (1999) · Oncogene · doi:10.1038/sj.onc.1202952 · Cited by 181 · see citing works

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome.

Rotter, V., Schwartz, D., Almon, E. B., Goldfinger, N., Kapon, A., Meshorer, A., Donehower, L. A., & Levine, A. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9075 · Cited by 180 · see citing works

The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM

Paull, T. T., & Lee, J. (2005) · Cell Cycle · doi:10.4161/cc.4.6.1715 · Cited by 178 · see citing works

p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.

Linke, S. P., Sengupta, S., Khabie, N., Jeffries, B. A., Buchhop, S., Miska, S., Henning, W., Pedeux, R., Wang, X. W., Hofseth, L. J., et al. (2003) · PubMed · Cited by 178 · see citing works

DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair

Akyüz, N., Boehden, G. S., Süße, S., Rimek, A., Preuß, U., Scheidtmann, K., & Wiesmüller, L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6306-6317.2002 · Cited by 175 · see citing works

Functional interactions between p53 and the TFIIH complex are affected by tumour‐associated mutations.

Léveillard, T., Anděra, L., Bissonnette, N., Schaeffer, L., Bracco, L. P., Egly, J., & Wasylyk, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00506.x · Cited by 173 · see citing works

Repair of Double-Strand Breaks by Homologous Recombination in Mismatch Repair-Defective Mammalian Cells

Elliott, B., & Jasin, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2671-2682.2001 · Cited by 169 · see citing works

p53 Binds and Activates the Xeroderma Pigmentosum <i>DDB2</i> Gene in Humans but Not Mice

Tan, T., & Chu, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3247-3254.2002 · Cited by 167 · see citing works

MRE11/RAD50/NBS1: complex activities

Aßenmacher, N., & Hopfner, K. (2004) · Chromosoma · doi:10.1007/s00412-004-0306-4 · Cited by 161 · see citing works

BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

MacLachlan, T. K., Takimoto, R., & El‐Deiry, W. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4280-4292.2002 · Cited by 160 · see citing works

Human p53 Binds Holliday Junctions Strongly and Facilitates Their Cleavage

Lee, S., Cavallo, L. M., & Griffith, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7532 · Cited by 152 · see citing works

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

Bertrand, P., Rouillard, D., Boulet, A., Levalois, C., Soussi, T., & López, B. S. (1997) · Oncogene · doi:10.1038/sj.onc.1200931 · Cited by 151 · see citing works

p53 accumulates but is functionally impaired when DNA synthesis is blocked

Gottifredi, V., Shieh, S.-Y., Taya, Y., & Prives, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1036 · Cited by 147 · see citing works

p53's double life: transactivation-independent repression of homologous recombination

Bertrand, P., Saintigny, Y., & López, B. S. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.04.003 · Cited by 145 · see citing works

Functional Interaction of p53 and BLM DNA Helicase in Apoptosis

Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S. F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103298200 · Cited by 145 · see citing works

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

Offer, H., Wolkowicz, R., Matas, D., Blumenstein, S., Livneh, Z., & Rotter, V. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00505-0 · Cited by 144 · see citing works

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

Grombacher, T., Eichhorn, U., & Kaina, B. (1998) · Oncogene · doi:10.1038/sj.onc.1202000 · Cited by 141 · see citing works

The Processing of Holliday Junctions by BLM and WRN Helicases Is Regulated by p53

Yang, Q., Zhang, R., Wang, X. W., Spillare, E. A., Linke, S. P., Subramanian, D., Griffith, J. D., Li, J. L., Hickson, I. D., Shen, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204111200 · Cited by 136 · see citing works

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R., Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405128 · Cited by 130 · see citing works

Specific Mismatch Recognition in Heteroduplex Intermediates by p53 Suggests a Role in Fidelity Control of Homologous Recombination

Dudenhöffer, C., Rohaly, G., Will, K., Deppert, W., & Wiesmüller, L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5332 · Cited by 129 · see citing works

Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity

Seemann, S., & Hainaut, P. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208549 · Cited by 121 · see citing works

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint

Saintigny, Y., Rouillard, D., Chaput, B., Soussi, T., & López, B. S. (1999) · Oncogene · doi:10.1038/sj.onc.1202941 · Cited by 121 · see citing works

Implication of p53 in base excision DNA repair: in vivo evidence

Seo, Y. R., Fishel, M. L., Amundson, S. A., Kelley, M. R., & Smith, M. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205129 · Cited by 115 · see citing works

Increased error-prone non homologous DNA end-joining – a proposed mechanism of chromosomal instability in Bloom's syndrome

Gaymes, T. J., North, P. S., Brady, N., Hickson, I. D., Mufti, G. J., & Rassool, F. V. (2002) · Oncogene · doi:10.1038/sj.onc.1205331 · Cited by 114 · see citing works

Roles for Mismatch Repair Factors in Regulating Genetic Recombination

Evans, E., & Alani, E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.7839-7844.2000 · Cited by 112 · see citing works

Identification of the mismatch repair genes <i>PMS2</i> and <i>MLH1</i> as p53 target genes by using serial analysis of binding elements

Chen, J., & Sadowski, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407069102 · Cited by 111 · see citing works

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

Abramova, N. А., Russell, J., Botchan, M. R., & Li, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7186 · Cited by 109 · see citing works

The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA

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The interaction of p53 with replication protein A mediates suppression of homologous recombination

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Dissociation of p53-mediated suppression of homologous recombination from G1/S cell cycle checkpoint control

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p53 and c-Jun Functionally Synergize in the Regulation of the DNA Repair Gene hMSH2 in Response to UV

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p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria

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Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA

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The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

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p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts.

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Dissociation of the recombination control and the sequence-specific transactivation function of P53

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Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

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A role for p53 in the frequency and mechanism of mutation

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Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage

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Different Capacities for Recombination in Closely Related Human Lymphoblastoid Cell Lines with Different Mutational Responses to X-Irradiation

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A Nucleotide Excision Repair Master-Switch: p53 Regulated Coordinate Introduction of Global Genomic Repair Genes

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In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

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Induction of murine O6-alkylguanine-DNA-alkyltransferase in response to ionising radiation is p53 gene dose dependent.

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p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thryroid cells

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Excision of mismatched nucleotides from DNA: a potential mechanism for enhancing DNA replication fidelity by the wild-type p53 protein

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The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase

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p53 Inhibits Strand Exchange and Replication Fork Regression Promoted by Human Rad51

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Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53

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Structural and functional involvement of p53 in BER in vitro and in vivo

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The role of p53 in base excision repair following genotoxic stress

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Wild-type and mutant forms of p53 activate human topoisomerase I: a possible mechanism for gain of function in mutants.

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Mending the Break: Two DNA Double-Strand Break Repair Machines in Eukaryotes

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Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53

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Potential roles for p53 in nucleotide excision repair

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Homologous recombination induced by replication inhibition, is stimulated by expression of mutant p53

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c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells

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Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.

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Role of tumor suppressor p53 domains in selective binding to supercoiled DNA

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Increased UV‐induced SCEs but normal repair of DNA damage in p53‐deficient mouse cells

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Identification of a p53 Response Element in the Promoter Region of the hMSH2 Gene Required for Expression in A2780 Ovarian Cancer Cells

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Wild-type p53 inhibits replication-associated homologous recombination

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ATR and ATM-Dependent Movement of BLM Helicase during Replication Stress Ensures Optimal ATM Activation and 53BP1 Focus Formation

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Decreased DNA Repair Efficiency by Loss or Disruption of p53 Function Preferentially Affects Removal of Cyclobutane Pyrimidine Dimers from Non-transcribed Strand and Slow Repair Sites in Transcribed Strand

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Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development.

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Association of p53 and MSH2 with recombinative repair complexes during S phase

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Analysis of the Binding of p53 to DNAs Containing Mismatched and Bulged Bases

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p53 in the Cytoplasm

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p53 Modulates RPA-Dependent and RPA-Independent WRN Helicase Activity

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Different Regulation of the p53 Core Domain Activities 3′-to-5′ Exonuclease and Sequence-Specific DNA Binding

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Complex Formation between p53 and Replication Protein A Inhibits the Sequence-Specific DNA Binding of p53 and Is Regulated by Single-Stranded DNA

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Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death

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p53 protects from replication-associated DNA double-strand breaks in mammalian cells

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A role for p53 in DNA end rejoining by human cell extracts

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Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged bases

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Exonucleolytic proofreading by p53 protein

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Loss of Heterozygosity Occurs via Mitotic Recombination in Trp53 +/− Mice and Associates with Mammary Tumor Susceptibility of the BALB/c Strain

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Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation

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Radiation-induced genetic instability in vivo depends on p53 status

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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

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p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair

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p53 Prevents the Accumulation of Double-Strand DNA Breaks at Stalled-Replication Forks Induced by UV in Human Cells

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p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation

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Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-α, a chemical inhibitor of p53

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Discriminatory suppression of homologous recombination by p53

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Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53

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Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase alpha-primase

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p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core

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Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: potential mechanism of DNA double-strand break repair modulation

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Involvement of p53 in X-ray induced intrachromosomal recombination in mice

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Substrate specificity of the p53-associated 3′-5′ exonuclease

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Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination

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P53 Activates Fanconi Anemia Group C Gene Expression

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Homeostatic Regulation of Base Excision Repair by a p53-Induced Phosphatase: Linking Stress Response Pathways with DNA Repair Proteins

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Recombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional Analysis

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Normal meiotic recombination in p53-deficient mice

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Modulation of p53 Binding to Holliday Junctions and 3-Cytosine Bulges by Phosphorylation Events

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Recombination at chromosomal sequences involved in leukaemogenic rearrangements is differentially regulated by p53

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p53 blocks RuvAB promoted branch migration and modulates resolution of Holliday junctions by RuvC

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Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat

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p53-mediated DNA renaturation can mimic strand exchange

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The tumor suppressor protein p53 stimulates the formation of the human topoisomerase I double cleavage complex in vitro

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Denaturation of dsDNA by p53: fluorescence correlation spectroscopy study

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The Tumor Suppressor p53 Can Reduce Stable Transfection in the Presence of Irradiation

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DNA binding and 3′–5′ exonuclease activity in the murine alternatively-spliced p53 protein

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The Effect of Functional Inactivation of TP53 by HPV-E6 Transformation on the Induction of Chromosome Aberrations by Gamma Rays in Human Tumor Cells

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Regulation of DNA double-strand break repair pathway choice

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The Cell–Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

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Census and evaluation of p53 target genes

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Thioredoxin and Related Molecules–From Biology to Health and Disease

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Coping with stress: multiple ways to activate p53

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Cell fate decision mediated by p53 pulses

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Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3

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p53 ancestry: gazing through an evolutionary lens

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Regulation of MCP-1 chemokine transcription by p53

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Overexpressed of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

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Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

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SURVEY AND SUMMARY Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability

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RAD51 can inhibit PDGF-B–induced gliomagenesis and genomic instability

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ATR inhibition preferentially targets homologous recombination-deficient tumor cells

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