The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
A random-walk/giant-loop model for interphase chromosomes.
Open accessAbstract
Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G0/G1 part of the cell cycle may consist of flexible chromatin loops, averaging approximately 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data. More general models consistent with the data are briefly discussed.
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Cites
Scaling concepts in polymer physics
Gordon, M. (1981) · Polymer · doi:10.1016/0032-3861(81)90183-x · Cited by 10,288
Scaling Concepts in Polymer Physics
de Gennes, P. G., & Witten, T. A. (1980) · Physics Today · doi:10.1063/1.2914118 · Cited by 9,348
Probability and Statistics With Reliability, Queuing, and Computer Science Applications.
Thompson, W. A., & Trivedi, K. S. (1983) · Journal of the American Statistical Association · doi:10.2307/2288237 · Cited by 2,601
Probability and Random Processes
(2004) · Elsevier eBooks · doi:10.1016/b978-0-12-172651-5.x5000-3 · Cited by 2,535
Spragg, S. P. (1979) · Nature · doi:10.1038/278085a0 · Cited by 1,707
Lichter, P., Cremer, T., Borden, J., Manuelidis, L., & Ward, D. C. (1988) · Human Genetics · doi:10.1007/bf01790090 · Cited by 1,160
Probability and Random Processes.
Foutz, R. V., Grimmett, G. R., & Stirzaker, D. R. (1993) · Journal of the American Statistical Association · doi:10.2307/2291308 · Cited by 646
Special matrices and their applications in numerical mathematics
Fiedler, M. (1986) · Springer eBooks · doi:10.1007/978-94-009-4335-3 · Cited by 427
Probability and statistics with reliability, queuing and computer science applications
Ferrari, D. (1983) · Performance Evaluation · doi:10.1016/0166-5316(83)90018-4 · Cited by 311
Estimating Genomic Distance from DNA Sequence Location in Cell Nuclei by a Random Walk Model
van den Engh, G., Sachs, R., & Trask, B. J. (1992) · Science · doi:10.1126/science.1388286 · Cited by 240
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Chromosome territories, nuclear architecture and gene regulation in mammalian cells
Cremer, T., & Cremer, C. (2001) · Nature Reviews Genetics · doi:10.1038/35066075 · Cited by 2,328
Three-dimensional folding and functional organization principles of the Drosophila genome
Sexton, T., Yaffe, E., Kenigsberg, E., Bantignies, F., Leblanc, B., Hoichman, M., Parrinello, H., Tanay, A., & Cavalli, G. (2012) · Cell · doi:10.1016/j.cell.2012.01.010 · Cited by 1,983
Sanborn, A. L., Rao, S. S. P., Huang, S.-C., Durand, N. C., Huntley, M. H., Jewett, A. I., Bochkov, I. D., Chinnappan, D., Cutkosky, A., Li, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518552112 · Cited by 1,730
Exploring the three-dimensional organization of genomes: Interpreting chromatin interaction data
Dekker, J., Marti-Renom, M. A., & Mirny, L. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3454 · Cited by 1,068
Chambeyron, S., & Bickmore, W. A. (2004) · Genes & Development · doi:10.1101/gad.292104 · Cited by 623
Metadata
- Authors
- Sachs, R. K., van den Engh, G., Trask, B., Yokota, H., & Hearst, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-03-28
- Volume
- 92
- Issue
- 7
- Pages
- 2710-2714
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012842652
- Cited by
- 301
- References
- 15
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Sachs, R. K., van den Engh, G., Trask, B., Yokota, H., & Hearst, J. E. (1995). A random-walk/giant-loop model for interphase chromosomes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.7.2710
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
