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A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.
Open accessAbstract
Amphiphysin, a major autoantigen in paraneoplastic Stiff-Man syndrome, is an SH3 domain-containing neuronal protein, concentrated in nerve terminals. Here, we demonstrate a specific, SH3 domain-mediated, interaction between amphiphysin and dynamin by gel overlay and affinity chromatography. In addition, we show that the two proteins are colocalized in nerve terminals and are coprecipitated from brain extracts consistent with their interactions in situ. We also report that a region of amphiphysin distinct from its SH3 domain mediates its binding to the alpha c subunit of AP2 adaptin, which is also concentrated in nerve terminals. These findings support a role of amphiphysin in synaptic vesicle endocytosis.
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Cited by
Doherty, G. J., & McMahon, H. T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081307.110540 · Cited by 3,075
BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
Peter, B. J., Kent, H. M., Mills, I. G., Vallis, Y., Butler, P. J. G., Evans, P. R., & McMahon, H. T. (2004) · Science · doi:10.1126/science.1092586 · Cited by 1,636
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,533
Endocytosis by random initiation and stabilization of clathrin-coated pits
Ehrlich, M., Boll, W., van Oijen, A., Hariharan, R., Chandran, K., Nibert, M. L., & Kirchhausen, T. (2004) · Cell · doi:10.1016/j.cell.2004.08.017 · Cited by 843
Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
Cremona, O., Di Paolo, G., Wenk, M. R., Lüthi, A., Kim, W. T., Takei, K., Daniell, L., Nemoto, Y., Shears, S. B., Flavell, R. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81649-9 · Cited by 834
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Metadata
- Authors
- David, C., McPherson, P. S., Mundigl, O., & de Camilli, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-01-09
- Volume
- 93
- Issue
- 1
- Pages
- 331-335
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975081377
- Cited by
- 409
- References
- 0
- FWCI
- 15.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- David, C., McPherson, P. S., Mundigl, O., & de Camilli, P. (1996). A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.1.331
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
