BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

Peter, Brian J.; Kent, Helen M.; Mills, Ian G.; Vallis, Yvonne; Butler, P. Jonathan G.; Evans, Philip R.; McMahon, Harvey T.

doi:10.1126/science.1092586

Cited by 1,636

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BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

Peter, Brian J., Kent, Helen M., Mills, Ian G., Vallis, Yvonne, Butler, P. Jonathan G., Evans, Philip R., McMahon, Harvey T.·2004·Science

DOI 10.1126/science.1092586

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Abstract

The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane curvature in vitro and in vivo. The structure is similar to that of arfaptin2, which we find also binds and tubulates membranes. From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module.

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Exon 7 encodes a portion of the N-BAR domain of BIN1 and is specific to isoforms 1, 2 and 3.
“Exon 7 encodes a portion of the N-BAR domain of BIN1 and is specific to isoforms 1, 2 and 3 [7, 37]”
From BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology (2020) · cites this paper as [7]

Curvature of clathrin-coated pits driven by epsin
Ford, M. G. J., Mills, I. G., Peter, B. J., Vallis, Y., Praefcke, G. J. K., Evans, P. R., & McMahon, H. T. (2002) · Nature · doi:10.1038/nature01020 · Cited by 1,019
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Research works printed but not linked: 45

10.1073/pnas.93.1.331 · DOI
10.1126/science.276.5310.259 · DOI
10.1016/S0960-9822(06)00254-5 · DOI
10.1091/mbc.8.10.2003 · DOI
10.1074/jbc.272.26.16700 · DOI · Paper page
10.1016/S0896-6273(02)00601-3 · DOI
10.1101/gad.207801 · DOI · Paper page
10.1242/dev.128.24.5005 · DOI · Paper page
10.1034/j.1600-0854.2001.21113.x · DOI · Paper page
10.1034/j.1600-0854.2002.30702.x · DOI
10.1126/science.1071362 · DOI
10.1038/9004 · DOI
10.1093/emboj/21.7.1661 · DOI
10.1016/S0092-8674(02)00688-8 · DOI
10.1074/jbc.M208568200 · DOI
10.1083/jcb.200107075 · DOI
10.1038/43613 · DOI
10.1074/jbc.M004069200 · DOI
10.1074/jbc.M103540200 · DOI
10.1006/geno.2000.6216 · DOI
10.1002/ijc.11200 · DOI
10.1016/S0014-5793(97)00928-9 · DOI
10.1074/jbc.M910430199 · DOI
10.1074/jbc.M104226200 · DOI
10.1126/science.291.5506.1051 · DOI · Paper page
10.1038/35075620 · DOI
10.1006/bbrc.2001.5330 · DOI
10.1093/emboj/16.17.5445 · DOI
10.1074/jbc.M102359200 · DOI
10.1016/S0968-0004(00)01644-3 · DOI
10.1073/pnas.070552297 · DOI · Paper page
10.1074/jbc.M202969200 · DOI
10.1016/S1044-7431(03)00078-2 · DOI
P. Billuartet al., Pathol. Biol.46, 678 (1998).
10.1128/MCB.16.6.3169 · DOI
10.1083/jcb.152.5.971 · DOI
10.1073/pnas.1432391100 · DOI
10.1038/nature01040 · DOI
10.1016/S0896-6273(00)00127-6 · DOI
10.1016/S0896-6273(00)80689-3 · DOI
10.1091/mbc.11.10.3277 · DOI
10.1074/jbc.M213222200 · DOI
10.1074/jbc.M308104200 · DOI
www.ncbi.nlm.nih.gov/Structure/cdd/cddfind.cgi
10.1016/0005-2736(86)90302-0 · DOI

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Authors: Peter, B. J., Kent, H. M., Mills, I. G., Vallis, Y., Butler, P. J. G., Evans, P. R., & McMahon, H. T.
Affiliations: Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-01-23
Volume: 303
Issue: 5657
Pages: 495-499
ISSN: 0036-8075
1095-9203
DOI: 10.1126/science.1092586
Cited by: 1,636
References: 1
Language: en

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BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

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