The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Smoothness within ruggedness: the role of neutrality in adaptation.
Open accessAbstract
RNA secondary structure folding algorithms predict the existence of connected networks of RNA sequences with identical structure. On such networks, evolving populations split into subpopulations, which diffuse independently in sequence space. This demands a distinction between two mutation thresholds: one at which genotypic information is lost and one at which phenotypic information is lost. In between, diffusion enables the search of vast areas in genotype space while still preserving the dominant phenotype. By this dynamic the success of phenotypic adaptation becomes much less sensitive to the initial conditions in genotype space.
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Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule.
Mills, D. R., Peterson, R. L., & Spiegelman, S. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.1.217 · Cited by 648
Transplanting a unique allosteric effect from crocodile into human haemoglobin
Komiyama, N. H., Miyazaki, G., Tame, J., & Nagai, K. (1995) · Nature · doi:10.1038/373244a0 · Cited by 81
Cited by
RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
Evolution, the Extended Synthesis
(2010) · The MIT Press eBooks · doi:10.7551/mitpress/9780262513678.001.0001 · Cited by 964
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Miller, J. F., & Thomson, P. (2000) · Lecture Notes in Computer Science · doi:10.1007/978-3-540-46239-2_9 · Cited by 914
Continuity in evolution: on the nature of transitions.
Fontana, W., & Schuster, P. (1998) · Science · doi:10.1126/science.280.5368.1451 · Cited by 456
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Metadata
- Authors
- Huynen, M. A., Stadler, P. F., & Fontana, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-01-09
- Volume
- 93
- Issue
- 1
- Pages
- 397-401
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971399377
- Cited by
- 539
- References
- 3
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Huynen, M. A., Stadler, P. F., & Fontana, W. (1996). Smoothness within ruggedness: the role of neutrality in adaptation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.1.397
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
