The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.
Open accessAbstract
Extracellular growth and differentiation factors induce changes in gene expression in the nucleus by initiating a series of protein associations that alter the subcellular localization of intracellular signaling proteins. Initial events involve receptor homo- or heterodimerization and subsequent recruitment of cytosolic signaling proteins to the inner leaflet of the plasma membrane. Intermediate events involve the translocation of proteins into the nucleus. Late events involve the recruitment of transcriptional activators to the vicinity of specific genes in the nucleus, resulting in increased gene transcription. The ability to induce signals at each of these three phases of signaling pathways is illustrated by the use of a heterodimeric chemical inducer of dimerization that causes a proximal relationship between two different target proteins.
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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Chemically induced proximity in biology and medicine
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Self-citationUnifying principles of bifunctional, proximity-inducing small molecules
Gerry, C. J., & Schreiber, S. L. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0469-1 · Cited by 199
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Wang, Y., Dix, M. M., Bianco, G., Remsberg, J. R., Lee, H.-Y., Kalocsay, M., Gygi, S. P., Forli, S., Vite, G., Lawrence, R. M., et al. (2019) · Nature Chemistry · doi:10.1038/s41557-019-0351-5 · Cited by 179
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Proximity and orientation underlie signaling by the non‐receptor tyrosine kinase ZAP70
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Metadata
- Authors
- Belshaw, P. J., Ho, S. N., Crabtree, G. R., & Schreiber, S. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-05-14
- Volume
- 93
- Issue
- 10
- Pages
- 4604-4607
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016955606
- Cited by
- 278
- References
- 1
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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