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Dimerization specificity of Arabidopsis MADS domain homeotic proteins APETALA1, APETALA3, PISTILLATA, and AGAMOUS.
Open accessAbstract
The MADS domain homeotic proteins APETALA1 (AP1), APETALA3 (AP3), PISTILLATA (PI), and AGAMOUS (AG) act in a combinatorial manner to specify the identity of Arabidopsis floral organs. The molecular basis for this combinatorial mode of action was investigated. Immunoprecipitation experiments indicate that all four proteins are capable of interacting with each other. However, these proteins exhibit "partner-specificity" for the formation of DNA-binding dimers; only AP1 homodimers, AG homodimers, and AP3/PI heterodimers are capable of binding to CArG-box sequences. Both the AP3/PI heterodimer and the AP1 or AG homodimers are formed when the three corresponding proteins are present together. The use of chimeric proteins formed by domain swapping indicates that the L region (which follows the MADS box) constitutes a key molecular determinant for the selective formation of DNA-binding dimers. The implications of these results for the ABC genetic model of flower development are discussed.
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Citations
Cited by
Complexes of MADS-box proteins are sufficient to convert leaves into floral organs
Honma, T., & Goto, K. (2001) · Nature · doi:10.1038/35054083 · Cited by 1,197
M OLECULAR B IOLOGY OF F RUIT M ATURATION AND R IPENING
Giovannoni, J. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.725 · Cited by 930
Theißen, G., & Saedler, H. (2001) · Nature · doi:10.1038/35054172 · Cited by 891
The AP2 domain of APETALA2 defines a large new family of DNA binding proteins in Arabidopsis
Okamuro, J. K., Caster, B., Villarroel, R., Van Montagu, M., & Jofuku, K. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.7076 · Cited by 685
Molecular mechanisms of flower development: an armchair guide
Krizek, B. A., & Fletcher, J. C. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1675 · Cited by 624
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Metadata
- Authors
- Riechmann, J. L., Krizek, B. A., & Meyerowitz, E. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-05-14
- Volume
- 93
- Issue
- 10
- Pages
- 4793-4798
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105334111
- Cited by
- 530
- References
- 0
- FWCI
- 17.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Riechmann, J. L., Krizek, B. A., & Meyerowitz, E. M. (1996). Dimerization specificity of Arabidopsis MADS domain homeotic proteins APETALA1, APETALA3, PISTILLATA, and AGAMOUS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.10.4793
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
