The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.
Open accessAbstract
Arachidonic acid (AA) metabolites derived from both cyclooxygenase (COX) and lipoxygenase (LOX) pathways transduce a variety of signals related to cell growth. Here, we report that the AA LOX pathway also functions as a critical regulator of cell survival and apoptosis. Rat Walker 256 (W256) carcinosarcoma cells express 12-LOX and synthesize 12(S)- and 15(S)-hydroxyeicosatetraenoic acids as their major LOX metabolites. W256 cells transfected with 12-LOX-specific antisense oligonucleotide or antisense oligonucleotides directed to conserved regions of LOXs underwent time- and dose-dependent apoptosis. Likewise, treatment of W256 cells with various LOX but not COX inhibitors induced apoptotic cell death, which could be partially inhibited by exogenous 12(S)- or 15(S)-hydroxyeicosatetraenoic acids. The W256 cell apoptosis induced by antisense oligos and LOX inhibitors was followed by a rapid downregulation of bcl-2 protein, a dramatic decrease in the bcl-2/bax ratio, and could be suppressed by bcl-2 overexpression. In contrast, p53, which is wild type in W256 cells, did not undergo alterations during apoptosis induction. The results suggest that the LOX pathway plays an important physiological role in regulating apoptosis.
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Cites
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Cited by
Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate
Brash, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23679 · Cited by 1,335
The Effect of Phospholipase A2Inhibitors on Proliferation and Apoptosis of Murine Intestinal Cells
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Metadata
- Authors
- Tang, D. G., Chen, Y. Q., & Honn, K. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-05-28
- Volume
- 93
- Issue
- 11
- Pages
- 5241-5246
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081324739
- Cited by
- 334
- References
- 24
- FWCI
- 28.18
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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