The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
Abstract
The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G 1 arrest requires the activity of wild‐type p53, as it is not observed in cells lacking functionally wild‐type protein, and at least some component of S phase and G 2/M arrests is also thought to be p53‐dependent. p53 functions as a transcription factor which binds specific DNA sequences, and recently major downstream targets have been identified, including p21 Cip1 an inhibitor of the cell cycle kinases that also blocks the replicative but not the repair function of DNA polymerase δ auxiliary factor, PCNA. Current interest focuses on developing novel cancer therapies based on our knowledge of the activity of p53 and p21 Cip1 in the cell cycle.
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Cites
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Cited by
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
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Is a p53-Regulated Inhibitor of G2/M Progression
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GADD45 induction of a G 2 /M cell cycle checkpoint
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Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways
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Metadata
- Authors
- Cox, L. S., & Lane, D. P.
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1995-06
- Volume
- 17
- Issue
- 6
- Pages
- 501-508
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2012732349
- Cited by
- 287
- References
- 12
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cox, L. S., & Lane, D. P. (1995). Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage. BioEssays. https://doi.org/10.1002/bies.950170606
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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