The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death.
Open accessAbstract
"Addiction modules" consist of two genes. In most of them the product of one is long lived and toxic while the product of the second is short lived and antagonizes the toxic effect; so far, they have been described mainly in a number of prokaryotic extrachromosomal elements responsible for the postsegregational killing effect. Here we show that the chromosomal genes mazE and mazF, located in the Escherichia coli rel operon, have all of the properties required for an addiction module. Furthermore, the expression of mazEF is regulated by the cellular level of guanosine [corrected] 3',5'-bispyrophosphate, the product of the RelA protein under amino acid starvation. These properties suggest that the mazEF system may be responsible for programmed cell death in E. coli and thus may have a role in the physiology of starvation.
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Cites
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Cited by
Thinking about Bacterial Populations as Multicellular Organisms
Shapiro, J. A. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.81 · Cited by 876
The N-end rule: functions, mysteries, uses
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Lewis, K. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.503-514.2000 · Cited by 616
Long-term survival during stationary phase: evolution and the GASP phenotype
Finkel, S. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1340 · Cited by 508
CRISPR-Cas: biology, mechanisms and relevance
Hille, F., & Charpentier, E. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0496 · Cited by 442
Metadata
- Authors
- Aizenman, E., Engelberg-Kulka, H., & Glaser, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-11
- Volume
- 93
- Issue
- 12
- Pages
- 6059-6063
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2017550427
- Cited by
- 599
- References
- 25
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Aizenman, E., Engelberg-Kulka, H., & Glaser, G. (1996). An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.12.6059
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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