The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
Open accessAbstract
Glial fibrillary acidic protein (GFAP) is a member of the family of intermediate filament structural proteins and is found predominantly in astrocytes of the central nervous system (CNS). To assess the function of GFAP, we created GFAP-null mice using gene targeting in embryonic stem cells. The GFAP-null mice have normal development and fertility, and show no gross alterations in behavior or CNS morphology. Astrocytes are present in the CNS of the mutant mice, but contain a severely reduced number of intermediate filaments. Since astrocyte processes contact synapses and may modulate synaptic function, we examined whether the GFAP-null mice were altered in long-term potentiation in the CA1 region of the hippocampus. The GFAP-null mice displayed enhanced long-term potentiation of both population spike amplitude and excitatory post-synaptic potential slope compared to control mice. These data suggest that GFAP is important for astrocyte-neuronal interactions, and that astrocyte processes play a vital role in modulating synaptic efficacy in the CNS. These mice therefore represent a direct demonstration that a primary defect in astrocytes influences neuronal physiology.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
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Cited by
Astrocyte activation and reactive gliosis
Pekny, M., & Nilsson, M. (2005) · Glia · doi:10.1002/glia.20207 · Cited by 1,611
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934
Hol, E. M., & Pekny, M. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.004 · Cited by 917
Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease
Brenner, M., Johnson, A. B., Boespflug-Tanguy, O., Rodriguez, D., Goldman, J. E., & Messing, A. (2001) · Nature Genetics · doi:10.1038/83679 · Cited by 688
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Metadata
- Authors
- McCall, M. A., Gregg, R. G., Behringer, R. R., Brenner, M., Delaney, C. L., Galbreath, E. J., Zhang, C. L., Pearce, R. A., Chiu, S. Y., & Messing, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-25
- Volume
- 93
- Issue
- 13
- Pages
- 6361-6366
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048734728
- Cited by
- 349
- References
- 5
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- green
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- McCall, M. A., Gregg, R. G., Behringer, R. R., Brenner, M., Delaney, C. L., Galbreath, E. J., Zhang, C. L., Pearce, R. A., Chiu, S. Y., & Messing, A. (1996). Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.13.6361
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
