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Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.
Open accessAbstract
Heat shock (HS) proteins (HSPs) induce protection against a number of stresses distinct from HS, including reactive oxygen species. In the human premonocytic line U937, we investigated in whole cells the effects of preexposure to HS and exposure to hydrogen peroxide (H2O2) on mitochondrial membrane potential, mass, and ultrastructure. HS prevented H2O2-induced alterations in mitochondrial membrane potential and cristae formation while increasing expression of HSPs and the protein product of bcl-2. Protection correlated best with the expression of the 70-kDa HSP, hsp70. We propose that mitochondria represent a selective target for HS-mediated protection against oxidative injury.
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Citations
Cited by
Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225
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Jäättelä, M., Wissing, D., Kokholm, K., Kallunki, T., & Egeblad, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6124 · Cited by 678
HSP90 as a new therapeutic target for cancer therapy: the story unfolds
Maloney, A., & Workman, P. (2002) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2.1.3 · Cited by 531
On the role of Hsp27 in regulating apoptosis
Concannon, C. G., Gorman, A. M., & Samali, A. (2003) · Apoptosis · doi:10.1023/a:1021601103096 · Cited by 513
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
De Maria, R., Lenti, L., Malisan, F., d'Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., & Testi, R. (1997) · Science · doi:10.1126/science.277.5332.1652 · Cited by 423
Metadata
- Authors
- Polla, B. S., Kantengwa, S., François, D., Salvioli, S., Franceschi, C., Marsac, C., & Cossarizza, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-25
- Volume
- 93
- Issue
- 13
- Pages
- 6458-6463
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147464247
- Cited by
- 402
- References
- 0
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. https://app.cochat.ai/papers/10.1073/pnas.93.13.6458
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- Polla, B. S., Kantengwa, S., François, D., Salvioli, S., Franceschi, C., Marsac, C., & Cossarizza, A. (1996). Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.13.6458
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
