The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis
Abstract
Gangliosides participate in development and tissue differentiation. Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation. CD95-induced GD3 accumulation depended on integral receptor “death domains” and on activation of a family of cysteine proteases called caspases. Cell-permeating ceramides, which are potent inducers of apoptosis, also triggered GD3 synthesis. GD3 disrupted mitochondrial transmembrane potential (ΔΨ m ), and induced apoptosis, in a caspase-independent fashion. Transient overexpression of the GD3 synthase gene directly triggered apoptosis. Pharmacological inhibition of GD3 synthesis and exposure to GD3 synthase antisense oligodeoxynucleotides prevented CD95-induced apoptosis. Thus, GD3 ganglioside mediates the propagation of CD95-generated apoptotic signals in hematopoietic cells.
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Metadata
- Authors
- De Maria, R., Lenti, L., Malisan, F., d'Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., & Testi, R.
- Venue
- Science
- Published
- 1997-09-12
- Volume
- 277
- Issue
- 5332
- Pages
- 1652-1655
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2160942082
- Cited by
- 423
- References
- 22
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- De Maria, R., Lenti, L., Malisan, F., d'Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., & Testi, R. (1997). Requirement for GD3 Ganglioside in CD95- and Ceramide-Induced Apoptosis. Science. https://doi.org/10.1126/science.277.5332.1652
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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