The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.
Open accessAbstract
A Saccharomyces cerevisiae strain with a disrupted yeast cadmium resistance factor (YCF1) gene (DTY168) is hypersensitive to cadmium. YCF1 resembles the human multidrug resistance-associated protein MRP (63% amino acid similarity), which confers resistance to various cytotoxic drugs by lowering the intracellular drug concentration. Whereas the mechanism of action of YCF1 is not known, MRP was recently found to transport glutathione S-conjugates across membranes. Here we show that expression of the human MRP cDNA in yeast mutant DTY168 cells restores cadmium resistance to the wild-type level. Transport of S-(2,4-dinitrobenzene)-glutathione into isolated yeast microsomal vesicles is strongly reduced in the DTY168 mutant and this transport is restored to wild-type level in mutant cells expressing MRP cDNA. We find in cell fractionation experiments that YCF1 is mainly localized in the vacuolar membrane in yeast, whereas MRP is associated both with the vacuolar membrane and with other internal membranes in the transformed yeast cells. Our results indicate that yeast YCF1 is a glutathione S-conjugate pump, like MRP, and they raise the possibility that the cadmium resistance in yeast involves cotransport of cadmium with glutathione derivatives.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
Cole, S. P. C., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M. V., & Deeley, R. G. (1992) · Science · doi:10.1126/science.1360704 · Cited by 3,037
Cited by
Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters
Song, W.-Y., Park, J., Mendoza-Cózatl, D. G., Suter-Grotemeyer, M., Shim, D., Hörtensteiner, S., Geisler, M., Weder, B., Rea, P. A., Rentsch, D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013964107 · Cited by 667
Self-citationEfflux-Mediated Antifungal Drug Resistance
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608
Kang, J., Park, J., Choi, H., Burla, B., Kretzschmar, T., Lee, Y., & Martinoia, E. (2011) · The Arabidopsis Book · doi:10.1199/tab.0153 · Cited by 573
Self-citationEngineering tolerance and accumulation of lead and cadmium in transgenic plants
Song, W.-Y., Ju Sohn, E., Martinoia, E., Jik Lee, Y., Yang, Y.-Y., Jasinski, M., Forestier, C., Hwang, I., & Lee, Y. (2003) · Nature Biotechnology · doi:10.1038/nbt850 · Cited by 423
Self-citationThe plant cDNA LCT1 mediates the uptake of calcium and cadmium in yeast
Clemens, S., Antosiewicz, D. M., Ward, J. M., Schachtman, D. P., & Schroeder, J. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.12043 · Cited by 293
Metadata
- Authors
- Tommasini, R., Evers, R., Vogt, E., Mornet, C., Zaman, G. J., Schinkel, A. H., Borst, P., & Martinoia, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-06-25
- Volume
- 93
- Issue
- 13
- Pages
- 6743-6748
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010242646
- Cited by
- 167
- References
- 1
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. https://app.cochat.ai/papers/10.1073/pnas.93.13.6743
- The paper
- Tommasini, R., Evers, R., Vogt, E., Mornet, C., Zaman, G. J., Schinkel, A. H., Borst, P., & Martinoia, E. (1996). The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.13.6743
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
