Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

Cole, S. P. C.; Bhardwaj, G.; Gerlach, J. H.; Mackie, J. E.; Grant, C. E.; Almquist, K. C.; Stewart, A. J.; Kurz, E. U.; Duncan, A. M. V.; Deeley, R. G.

doi:10.1126/science.1360704

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

The doxorubicin-selected lung cancer cell line H69AR is resistant to many chemotherapeutic agents. However, like most tumor samples from individuals with this disease, it does not overexpress P-glycoprotein, a transmembrane transport protein that is dependent on adenosine triphosphate (ATP) and i…