Neural plasticity in adults with amblyopia.
Open accessAbstract
Amblyopia is a neuronal abnormality of vision that is often considered irreversible in adults. We found strong and significant improvement of Vernier acuity in human adults with naturally occurring amblyopia following practice. Learning was strongest at the trained orientation and did not transfer to an untrained task (detection), but it did transfer partially to the untrained eye (primarily at the trained orientation). We conclude that this perceptual learning reflects alterations in early neural processes that are localized beyond the site of convergence of the two eyes. Our results suggest a significant degree of plasticity in the visual system of adults with amblyopia.
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Once a developmental critical period for ocular dominance plasticity is closed, the capacity for ODP is significantly reduced in visual cortex.
“Once a developmental time window or”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Levi and Polat, 1996
Cites
Neuronal Plasticity That Underlies Improvement in Perceptual Performance
Zohary, E., Celebrini, S., Britten, K. H., & Newsome, W. T. (1994) · Science · doi:10.1126/science.8122114 · Cited by 247 · see citing works
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Learning to see: experience and attention in primary visual cortex
Crist, R. E., Li, W., & Gilbert, C. D. (2001) · Nature Neuroscience · doi:10.1038/87470 · Cited by 364 · see citing works
Nurturing brain plasticity: Impact of environmental enrichment
Baroncelli, L., Braschi, C., Spolidoro, M., Begenisic, T., Sale, A., & Maffei, L. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.193 · Cited by 330 · see citing works
Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82 · see citing works
“…window or “ critical period ” for ODP is closed, the capacity for ODP is significantly reduced in visual cortex; this neurobiological feature presents scientists with a way to test the plasticity-promoting effects of drugs and their mechanisms for doing so in adult animals (Levi and Polat, 1996).”
- Authors
- Levi, D. M., & Polat, U.
- Affiliations
- University of Houston (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-06-25
- Volume
- 93
- Issue
- 13
- Pages
- 6830-6834
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC39113
- OpenAlex
- W2164146383
- Cited by
- 234
- References
- 1
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 13 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 10 · 2015: 17 · 2014: 9 · 2013: 13 · 2012: 8
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey001128-16)
- National Eye Institute (R01EY01128)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- amblyopia, adult amblyopia, perceptual learning, neuroplasticity, vernier acuity, orientation discrimination, transfer of learning, visual plasticity, binocular vision
- MeSH terms
- Adult, Amblyopia, Humans, Neuronal Plasticity, Vision, Ocular, Observer Variation
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