The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.
Open accessAbstract
Presynaptic Ca2+ channels are crucial elements in neuronal excitation-secretion coupling. In addition to mediating Ca2+ entry to initiate transmitter release, they are thought to interact directly with proteins of the synaptic vesicle docking/fusion machinery. Here we report isoform-specific, stoichiometric interaction of the BI and rbA isoforms of the alpha1A subunit of P/Q-type Ca2+ channels with the presynaptic membrane proteins syntaxin and SNAP-25 in vitro and in rat brain membranes. The BI isoform binds to both proteins, while only interaction with SNAP-25 can be detected in vitro for the rbA isoform. The synaptic protein interaction ("synprint") site involves two adjacent segments of the intracellular loop connecting domains II and III between amino acid residues 722 and 1036 of the BI sequence. This interaction is competitively blocked by the corresponding region of the N-type Ca2+ channel, indicating that these two channels bind to overlapping regions of syntaxin and SNAP-25. Our results provide a molecular basis for a physical link between Ca2+ influx into nerve terminals and subsequent exocytosis of neurotransmitters at synapses that have presynaptic Ca2+ channels containing alpha1A subunits.
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Cites
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Chapman, E. R., An, S., Barton, N., & Jahn, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47003-2 · Cited by 295
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Self-citationVoltage-Gated Calcium Channels
Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628
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Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction
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Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647
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Metadata
- Authors
- Rettig, J., Sheng, Z. H., Kim, D. K., Hodson, C. D., Snutch, T. P., & Catterall, W. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-09
- Volume
- 93
- Issue
- 14
- Pages
- 7363-7368
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042048113
- Cited by
- 325
- References
- 2
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Rettig, J., Sheng, Z. H., Kim, D. K., Hodson, C. D., Snutch, T. P., & Catterall, W. A. (1996). Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.14.7363
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