PreprintCited by 1,628Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Channels and Receptors

Voltage-Gated Calcium Channels

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Catterall, W. A.·2011·Cold Spring Harbor Perspectives in Biology

Abstract

Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.

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Crossref · 10.1101/cshperspect.a003947

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  • The alpha-1 subunit of CaV channels is the pore-forming subunit and has a fundamental role in the selective gating and regulated entry of calcium ions into cells.

    “The alpha-1 subunit of CaV channels is the pore-forming subunit and has a fundamental role in the selective gating and regulated entry of calcium ions into cells55,56.”
  • Two theories have been proposed for how electromagnetic fields modulate Cav2+ channels: depolarization of the cell membrane, and direct action on the charged residues in the voltage-sensing S4 segment adjacent to the pore.

    “To answer the first question, two theories have been proposed for how electromagnetic fields modulate Cav2+ channels: (1) by depolarization of the cell membrane, which is typically employed in mechanism of action explanations of voltage-gated ion channels such as Nav+, Kv+, and Cav2+ [48] and (2) by direct action on the charged residues in the voltage-sensing S4 segment adjacent to the pore that”

    From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [50]

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Authors
Catterall, W. A.
Affiliations
University of Washington (US)
Corresponding author
Catterall, W. A.
Venue
Cold Spring Harbor Perspectives in Biology
Published
2011-07-11
Volume
3
Issue
8
Pages
a003947-a003947
ISSN
1943-0264 (ISSN-L)
OpenAlex
W2096701787
Cited by
1,628
References
222
Citations by year
2026: 79 · 2025: 107 · 2024: 130 · 2023: 116 · 2022: 130 · 2021: 129 · 2020: 122 · 2019: 143 · 2018: 112 · 2017: 93 · 2016: 97 · 2015: 92 · 2014: 110 · 2013: 77 · 2012: 56
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Perspectives in Biology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS022625)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
voltage-gated calcium channels, calcium transients, membrane potential, synaptic transmission, ribbon synapses, cardiomyocytes, thalamic neurons, action potential firing, gene expression regulation, calcium channel pharmacology
MeSH terms
Animals, Calcium Channel Blockers, Humans, Models, Biological, Synaptic Transmission, Calcium Channels, Protein Structure, Tertiary, Calcium Signaling, Protein Structure, Quaternary, Excitation Contraction Coupling

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