Voltage-Gated Calcium Channels
Open accessAbstract
Voltage-gated calcium (Ca(2+)) channels are key transducers of membrane potential changes into intracellular Ca(2+) transients that initiate many physiological events. There are ten members of the voltage-gated Ca(2+) channel family in mammals, and they serve distinct roles in cellular signal transduction. The Ca(V)1 subfamily initiates contraction, secretion, regulation of gene expression, integration of synaptic input in neurons, and synaptic transmission at ribbon synapses in specialized sensory cells. The Ca(V)2 subfamily is primarily responsible for initiation of synaptic transmission at fast synapses. The Ca(V)3 subfamily is important for repetitive firing of action potentials in rhythmically firing cells such as cardiac myocytes and thalamic neurons. This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties.
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The alpha-1 subunit of CaV channels is the pore-forming subunit and has a fundamental role in the selective gating and regulated entry of calcium ions into cells.
“The alpha-1 subunit of CaV channels is the pore-forming subunit and has a fundamental role in the selective gating and regulated entry of calcium ions into cells55,56.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [55]
Two theories have been proposed for how electromagnetic fields modulate Cav2+ channels: depolarization of the cell membrane, and direct action on the charged residues in the voltage-sensing S4 segment adjacent to the pore.
“To answer the first question, two theories have been proposed for how electromagnetic fields modulate Cav2+ channels: (1) by depolarization of the cell membrane, which is typically employed in mechanism of action explanations of voltage-gated ion channels such as Nav+, Kv+, and Cav2+ [48] and (2) by direct action on the charged residues in the voltage-sensing S4 segment adjacent to the pore that”
From Permeabilizing Cell Membranes with Electric Fields (2021) · cites this paper as [50]
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“The alpha-1 subunit of Ca V channels is the pore-forming subunit and has a fundamental role in the selective gating and regulated entry of calcium ions into cells 55,56 .”
- Authors
- Catterall, W. A.
- Affiliations
- University of Washington (US)
- Corresponding author
- Catterall, W. A.
- ORCID
- Catterall, W. A.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-07-11
- Volume
- 3
- Issue
- 8
- Pages
- a003947-a003947
- ISSN
- 1943-0264 (ISSN-L)
- PMC
- PMC3140680
- OpenAlex
- W2096701787
- Cited by
- 1,628
- References
- 222
- Citations by year
- 2026: 79 · 2025: 107 · 2024: 130 · 2023: 116 · 2022: 130 · 2021: 129 · 2020: 122 · 2019: 143 · 2018: 112 · 2017: 93 · 2016: 97 · 2015: 92 · 2014: 110 · 2013: 77 · 2012: 56
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS022625)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- voltage-gated calcium channels, calcium transients, membrane potential, synaptic transmission, ribbon synapses, cardiomyocytes, thalamic neurons, action potential firing, gene expression regulation, calcium channel pharmacology
- MeSH terms
- Animals, Calcium Channel Blockers, Humans, Models, Biological, Synaptic Transmission, Calcium Channels, Protein Structure, Tertiary, Calcium Signaling, Protein Structure, Quaternary, Excitation Contraction Coupling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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