The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a pathogenicity island required for Salmonella survival in host cells.
Open accessAbstract
We have identified a region unique to the Salmonella typhimurium chromosome that is essential for virulence in mice. This region harbors at least three genes: two (spiA and spiB) encode products that are similar to proteins found in type III secretion systems, and a third (spiR) encodes a putative regulator. A strain with a mutation in spiA was unable to survive within macrophages but displayed wild-type levels of epithelial cell invasion. The culture supernatants of the spi mutants lacked a modified form of flagellin, which was present in the supernatant of the wild-type strain. This suggests that the Spi secretory apparatus exports a protease, or a protein that can alter the activity of a secreted protease. The "pathogenicity island" harboring the spi genes may encode the virulence determinants that set Salmonella apart from other enteric pathogens.
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Citations
Cites
Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants
Lee, C. A., Jones, B. D., & Falkow, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1847 · Cited by 296
Cited by
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Self-citationEriksson, S., Lucchini, S., Thompson, A., Rhen, M., & Hinton, J. C. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03313.x · Cited by 846
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Salmonella, the host and disease: a brief review
Coburn, B., Grassl, G. A., & Finlay, B. B. (2007) · Immunology & Cell Biology · doi:10.1038/sj.icb.7100007 · Cited by 690
Metadata
- Authors
- Ochman, H., Soncini, F. C., Solomon, F., & Groisman, E. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-07-23
- Volume
- 93
- Issue
- 15
- Pages
- 7800-7804
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2170484617
- Cited by
- 652
- References
- 1
- FWCI
- 45.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Ochman, H., Soncini, F. C., Solomon, F., & Groisman, E. A. (1996). Identification of a pathogenicity island required for Salmonella survival in host cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.15.7800
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
