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Altered surfactant function and structure in SP-A gene targeted mice.
Open accessAbstract
The surfactant protein A (SP-A) gene was disrupted by homologous recombination in embryonic stem cells that were used to generate homozygous SP-A-deficient mice. SP-A mRNA and protein were not detectable in the lungs of SP-A(-/-) mice, and perinatal survival of SP-A(-/-) mice was not altered compared with wild-type mice. Lung morphology, surfactant proteins B-D, lung tissue, alveolar phospholipid pool sizes and composition, and lung compliance in SP-A(-/-) mice were unaltered. At the highest concentration tested, surfactant from SP-A(-/-) mice produced the same surface tension as (+/+) mice. At lower concentrations, minimum surface tensions were higher for SP-A(-/-) mice. At the ultrastructural level, type II cell morphology was the same in SP-A(+/+) and (-/-) mice. While alveolar phospholipid pool sizes were unperturbed, tubular myelin figures were decreased in the lungs of SP-A(-/-) mice. A null mutation of the murine SP-A gene interferes with the formation of tubular myelin without detectably altering postnatal survival or pulmonary function.
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Cited by
Surfactant proteins SP-A and SP-D: structure, function and receptors
Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523
Wu, H., Kuzmenko, A., Wan, S., Schaffer, L., Weiss, A., Fisher, J. H., Kim, K. S., & McCormack, F. X. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16889 · Cited by 412
Stat-3 is required for pulmonary homeostasis during hyperoxia
Hokuto, I., Ikegami, M., Yoshida, M., Takeda, K., Akira, S., Perl, A.-K. T., Hull, W. M., Wert, S. E., & Whitsett, J. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19491 · Cited by 128
Self-citationRecent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
Sahu, I., Haque, A. K. M. A., Weidensee, B., Weinmann, P., & Kormann, M. S. D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.019 · Cited by 104
Metadata
- Authors
- Korfhagen, T. R., Bruno, M. D., Ross, G. F., Huelsman, K. M., Ikegami, M., Jobe, A. H., Wert, S. E., Stripp, B. R., Morris, R. E., Glasser, S. W., Bachurski, C. J., Iwamoto, H. S., & Whitsett, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-09-03
- Volume
- 93
- Issue
- 18
- Pages
- 9594-9599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2105114931
- Cited by
- 405
- References
- 0
- FWCI
- 36.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Korfhagen, T. R., Bruno, M. D., Ross, G. F., Huelsman, K. M., Ikegami, M., Jobe, A. H., Wert, S. E., Stripp, B. R., Morris, R. E., Glasser, S. W., Bachurski, C. J., Iwamoto, H. S., & Whitsett, J. A. (1996). Altered surfactant function and structure in SP-A gene targeted mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.18.9594
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