Cited by 104RNA Interference and Gene DeliveryInhalation and Respiratory Drug DeliveryRNA and protein synthesis mechanisms

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

Open access
Sahu, Itishri, Haque, A.K.M. Ashiqul, Weidensee, Brian, Weinmann, Petra, Kormann, Michael S.D.·2019·Molecular Therapy

Abstract

Protein supplementation therapy using in vitro-transcribed (IVT) mRNA for genetic diseases contains huge potential as a new class of therapy. From the early ages of synthetic mRNA discovery, a great number of studies showed the versatile use of IVT mRNA as a novel approach to supplement faulty or absent protein and also as a vaccine. Many modifications have been made to produce high expressions of mRNA causing less immunogenicity and more stability. Recent advancements in the in vivo lung delivery of mRNA complexed with various carriers encouraged the whole mRNA community to tackle various genetic lung diseases. This review gives a comprehensive overview of cells associated with various lung diseases and recent advancements in mRNA-based protein replacement therapy. This review also covers a brief summary of developments in mRNA modifications and nanocarriers toward clinical translation.

Integrity signals

Registry

Crossref · 10.1016/j.ymthe.2019.02.019

Cites

330 of 330 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • mRNA-based protein replacement therapies are also being explored for heart, liver, lung and other organ diseases.

    “mRNA-based protein replacement therapies are also being explored for heart241, liver242, lung243 and other organ diseases12.”

    From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [243]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sahu, I., Haque, A. K. M. A., Weidensee, B., Weinmann, P., & Kormann, M. S. D.
Affiliations
University Children's Hospital Tübingen (DE)
Corresponding author
Kormann, Michael S.D.
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2019-04
Volume
27
Issue
4
Pages
803-823
ISSN
1525-0016 (ISSN-L)
OpenAlex
W2921986119
Cited by
104
References
330
Citations by year
2026: 7 · 2025: 21 · 2024: 14 · 2023: 24 · 2022: 16 · 2021: 13 · 2020: 7 · 2019: 2
FWCI
0.84
Type
journal article
Language
en
Open access
Locations
  • Molecular Therapy (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Research Council (637752)
  • HMZ Privatstiftung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
in vitro transcribed mRNA, mRNA modification, nanocarriers, mRNA vaccines, immunogenicity reduction, clinical translation
MeSH terms
Animals, Humans, Lipids, Lung, Lung Diseases, Polymers, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Drug Delivery Systems, Mice, Nanoparticles, Enzyme Replacement Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review