The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.
Open accessAbstract
Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526 antagonizes the stimulatory effects of exogenous CRF on plasma ACTH, locus coeruleus neuronal firing and startle response amplitude. Potential anxiolytic activity of CP-154,526 was revealed in a fearpotentiated startle paradigm. These data are presented in the context of clinical findings, which suggest that CRF is hypersecreted in certain pathological states. We propose that a CRF antagonist such as CP-154,526 could affirm the role of CRF in certain psychiatric diseases and may be of significant value in the treatment of these disorders.
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Cites
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Rivier, C., & Vale, W. (1983) · Nature · doi:10.1038/305325a0 · Cited by 539
The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry: Commentary and Review
Arana, G. W. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790350067012 · Cited by 526
Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide
Swerdlow, N. R., Geyer, M. A., Vale, W. W., & Koob, G. F. (1986) · Psychopharmacology · doi:10.1007/bf00652231 · Cited by 299
Cited by
Neuroendocrine pharmacology of stress
Carrasco, G. A., & Van de Kar, L. D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01285-8 · Cited by 914
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880
Zobel, A. W., Nickel, T., Künzel, H. E., Ackl, N., Sonntag, A., Ising, M., & Holsboer, F. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00016-9 · Cited by 705
Holsboer, F. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)90056-5 · Cited by 654
Metadata
- Authors
- Schulz, D. W., Mansbach, R. S., Sprouse, J., Braselton, J. P., Collins, J., Corman, M., Dunaiskis, A., Faraci, S., Schmidt, A. W., Seeger, T., Seymour, P., Tingley, F. D., Winston, E. N., Chen, Y. L., & Heym, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-09-17
- Volume
- 93
- Issue
- 19
- Pages
- 10477-10482
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2171846995
- Cited by
- 377
- References
- 5
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Schulz, D. W., Mansbach, R. S., Sprouse, J., Braselton, J. P., Collins, J., Corman, M., Dunaiskis, A., Faraci, S., Schmidt, A. W., Seeger, T., Seymour, P., Tingley, F. D., Winston, E. N., Chen, Y. L., & Heym, J. (1996). CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.19.10477
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
